The Resource A genetic linkage map of the fungus phycomyces blakesleeanus for gene identification by map-based cloning, Suman Chaudhary, (electronic resource)

A genetic linkage map of the fungus phycomyces blakesleeanus for gene identification by map-based cloning, Suman Chaudhary, (electronic resource)

Label
A genetic linkage map of the fungus phycomyces blakesleeanus for gene identification by map-based cloning
Title
A genetic linkage map of the fungus phycomyces blakesleeanus for gene identification by map-based cloning
Statement of responsibility
Suman Chaudhary
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
The Mucoromycotina is one of the basal lineages in the fungi, all of which are poorly understood. Mucormycosis is a life threatening infection caused by fungi of the order Mucorales, the most common species of which is Rhizopus oryzae. Certain genetic traits in fungal genomes are thought to influence their ability to cause disease. This fungus is closely related to Phycomyces blakesleeanus, for certain common properties like taxonomic classification and including response to environmental signals. In view of these common properties, Phycomyces presents itself as an important model to study pathogenic determinants of Rhizopus infection. P. blakesleeanus is a zygomycete fungus classified in the subphylum Mucoromycotina, studied because of its environmental sensing abilities and responses, and its ability to synthesize the pigment beta-carotene. Light is an environmental signal that modulates many aspects of fungal biology including the ability to cause disease. There are eight unknown light-sensing mad genes in Phycomyces. The inability to transform DNA into Phycomyces has blocked the identification of genes in this fungus. In this research, a genetic map based on 100 molecular markers, assigned to 121 progeny, was generated in a cross between two wild type strains NRRL1555 and UBC21. The map comprised 1037.8 cM spread over 11 linkage groups. The map was then used as the starting point for the choice of markers for the map-based identification of madC, by crossing madC mutants to strain UBC21. madC was identified as a new gene required for fungal responses to their environment. The madC gene encodes a Ras GTPase activating protein. These findings indicate that the Ras signal transduction pathway plays role in light sensing. Because both light sensing and Ras signaling are required for virulence in other fungal species, a future direction would be to test if mutation of the madC gene has an effect on disease caused by pathogenic members of the Mucoromycotina. By identifying the mad light-sensing genes of Phycomyces, this research can be potentially translated into therapeutics by drug discovery of those genes with roles in both light-sensing and pathogenicity
Cataloging source
UMK
http://library.link/vocab/creatorName
Chaudhary, Suman
Degree
M.S.
Dissertation year
2012.
Granting institution
School of Medicine and School of Biological Sciences. University of Missouri-Kansas City
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
Idnurm, Alexander
http://library.link/vocab/subjectName
  • Phycomyces blakesleeanus
  • Fungi
  • Fungi
Label
A genetic linkage map of the fungus phycomyces blakesleeanus for gene identification by map-based cloning, Suman Chaudhary, (electronic resource)
Instantiates
Publication
Note
  • "A thesis in Bioinformatics and Clinical Research & Cell Biology and Biophysics."
  • Advisor: Alexander Idnurm
  • Vita
Antecedent source
not applicable
Bibliography note
Includes bibliographical references (pages 45-47)
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
black and white
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Introduction -- Materials and methods -- Results -- Discussion -- Appendix
Control code
824512264
Dimensions
unknown
Extent
1 online resource (60 pages)
File format
one file format
Form of item
online
Level of compression
mixed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
color illustrations
Quality assurance targets
not applicable
Specific material designation
remote
System control number
(OCoLC)824512264
System details
  • The full text of the thesis is available as an Adobe Acrobat .pdf file; Adobe Acrobat Reader required to view the file
  • Mode of access: World Wide Web
Label
A genetic linkage map of the fungus phycomyces blakesleeanus for gene identification by map-based cloning, Suman Chaudhary, (electronic resource)
Publication
Note
  • "A thesis in Bioinformatics and Clinical Research & Cell Biology and Biophysics."
  • Advisor: Alexander Idnurm
  • Vita
Antecedent source
not applicable
Bibliography note
Includes bibliographical references (pages 45-47)
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
black and white
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Introduction -- Materials and methods -- Results -- Discussion -- Appendix
Control code
824512264
Dimensions
unknown
Extent
1 online resource (60 pages)
File format
one file format
Form of item
online
Level of compression
mixed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
color illustrations
Quality assurance targets
not applicable
Specific material designation
remote
System control number
(OCoLC)824512264
System details
  • The full text of the thesis is available as an Adobe Acrobat .pdf file; Adobe Acrobat Reader required to view the file
  • Mode of access: World Wide Web

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