Coverart for item
The Resource A mouse model of embolic focal ischemic stroke for investigation of anti-thrombotic therapies, by Rong Hu, (electronic resource)

A mouse model of embolic focal ischemic stroke for investigation of anti-thrombotic therapies, by Rong Hu, (electronic resource)

Label
A mouse model of embolic focal ischemic stroke for investigation of anti-thrombotic therapies
Title
A mouse model of embolic focal ischemic stroke for investigation of anti-thrombotic therapies
Statement of responsibility
by Rong Hu
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
Stroke is the third leading cause of death in the United States and the major cause of adult disability. Ischemic stroke accounts for about 87 percent of all cases, and is a condition in which there is insufficient blood flow and poor oxygen supply to the brain to meet metabolic demand, thus causing complex pathophysiology and damage to neurons and glial cells. Release of excitatory neurotransmitters such as glutamate and activation of ionotropic glutamate receptors such as that mediated by N-methyl-D-aspartic acid (NMDA) contribute to influx of calcium and stimulation of a train of events leading to mitochondrial dysfunction and neuronal apoptosis. Ischemia also triggers activation of matrix metalloproteinases (MMPs), known to play a role in degradation of extracellular matrix and disruption of blood brain barrier (BBB) and induction of neuronal cell death. Even though there are several models to mimic the effects of ischemic stroke, the embolic focal cerebral ischemic model is unique and one representing the most relevant physiological changes of ischemic stroke in human. Therefore, this embolic ischemic model may be used to identify the ischemia/stroke-induced brain damage due to lack of oxygen supply and other physiological stress, and studies to investigate potential drugs or agents for therapeutic purposes
Cataloging source
MUU
http://library.link/vocab/creatorDate
1980-
http://library.link/vocab/creatorName
Hu, Rong
Degree
M. S.
Dissertation year
2010.
Granting institution
University of Missouri--Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
Gu, Zezong
http://library.link/vocab/subjectName
  • Brain damage
  • Brain damage
  • Cerebrovascular disease
  • Drugs
  • Mitochondrial pathology
  • Cell death
Target audience
specialized
Label
A mouse model of embolic focal ischemic stroke for investigation of anti-thrombotic therapies, by Rong Hu, (electronic resource)
Instantiates
Publication
Note
  • Title from PDF of title page (University of Missouri--Columbia, viewed on November 3, 2010)
  • The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file
  • Thesis advisor: Dr. Zezong Gu
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
733775570
Extent
1 online resource (xiv, 86 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
MU: Access is limited to the University of Missouri - Columbia.
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)733775570
Label
A mouse model of embolic focal ischemic stroke for investigation of anti-thrombotic therapies, by Rong Hu, (electronic resource)
Publication
Note
  • Title from PDF of title page (University of Missouri--Columbia, viewed on November 3, 2010)
  • The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file
  • Thesis advisor: Dr. Zezong Gu
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
733775570
Extent
1 online resource (xiv, 86 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
MU: Access is limited to the University of Missouri - Columbia.
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)733775570

Library Locations

    • Ellis LibraryBorrow it
      1020 Lowry Street, Columbia, MO, 65201, US
      38.944491 -92.326012
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