Coverart for item
The Resource Alternatives to animal testing, editors, R.E. Hester and R.M. Harrison, (electronic resource)

Alternatives to animal testing, editors, R.E. Hester and R.M. Harrison, (electronic resource)

Label
Alternatives to animal testing
Title
Alternatives to animal testing
Statement of responsibility
editors, R.E. Hester and R.M. Harrison
Contributor
Subject
Language
eng
Summary
(Publisher-supplied data) Animal experimentation has long been a controversial issue, with impassioned arguments on both sides of the debate. Increasingly it has become more expedient and feasible to develop new methods that avoid the use of animals. There is agreement on both sides that reduction and refinement of experiments on animals should be an important goal for the industries involved. Alternatives to Animal Testing, written by leading experts in the field, discusses the issues involved and approaches that can be taken. Topics include: the safety evaluation of chemicals; international validation and barriers to the validation of alternative tests; in vitro testing for endocrine disruptors; intelligent approaches to safety evaluation of chemicals; alternative tests and the regulatory framework. The book provides an up-to-date discussion of the current state of development of alternatives to animal testing and is ideal for professionals and academics in the field. It would also be of use for graduate students wishing to pursue a career in the pharmaceutical and cosmetics industries
Member of
Cataloging source
UAT
Dewey number
  • 615.9/07
  • 616.027
LC call number
RA1199.4.A46
LC item number
A48 2006
NAL call number
RA1199.4.A46
NAL item number
A48 2006
NLM call number
  • 2010 H-559
  • W 20.55.A5
http://library.link/vocab/relatedWorkOrContributorDate
1948-
http://library.link/vocab/relatedWorkOrContributorName
  • Hester, R. E.
  • Harrison, Roy M.
  • Royal Society of Chemistry (Great Britain)
Series statement
Issues in environmental science and technology,
Series volume
23
http://library.link/vocab/subjectName
  • Animal Use Alternatives
  • Animal Experimentation
Label
Alternatives to animal testing, editors, R.E. Hester and R.M. Harrison, (electronic resource)
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Contents
GENERAL OVERVIEW OF THE SAFETY EVALUATION OF CHEMICALS / Paul Illing -- Introduction -- Legislation and regulatory requirements -- The regulatory paradigm -- The interface between toxicology and risk assessment -- Interpreting toxicology -- Conclusions -- References -- INTERNATIONAL VALIDATION AND BARRIERS TO THE VALIDATION OF ALTERNATIVE TESTS / Michael Balls -- Introduction -- Background to the validation process -- The validation process -- Problems being encountered in implementing the validation process -- The need for an invalidation process -- Concluding remarks -- References -- IN VITRO TESTING FOR ENDOCRINE DISRUPTORS / Robert D. Combes -- Introduction -- In silico approaches -- In vitro tests for EDs -- Discussion -- Conclusions -- Acknowledgment -- References -- iNTELLIGENT APPROACHES TO SAFETY EVALUATION / Derek J. Knight -- Introduction -- Hazardous properties assessment -- Risk assessment -- Existing studies and literature data -- Surrogate data: calculation, read across and SAR/QSAR -- Alternatives to animal toxicology studies -- Data waivers -- Expert reports and weight of evidence -- Preliminary risk assessments -- EU Registration, Evaluation and Registration Scheme (REACH) -- Data for REACH -- Regulatory planning & liaison with the regulators -- Common themes -- Acknowledgments -- References -- ALTERNATIVE TESTS AND THE 7TH AMENDMENT TO THE COSMETICS DIRECTIVE / Carl Westmoreland -- Introduction -- Overview of current approaches to risk assessment for cosmetics -- 7th Amendment to the EU Cosmetics Directive (76/768/EEC) -- Status of alternative tests -- Endpoints where risk assessment for cosmetics can be achieved without using animal data -- Endpoints where risk assessment for cosmetics cannot currently be achieved without using animal data -- New approaches to risk assessment without animals -- Acknowledgments -- Abbreviations -- References
Control code
OCM1bookssj0000352631
Dimensions
unknown
Isbn
9780854042111
Lccn
2006494634
Specific material designation
remote
System control number
(WaSeSS)bookssj0000352631
Label
Alternatives to animal testing, editors, R.E. Hester and R.M. Harrison, (electronic resource)
Publication
Bibliography note
Includes bibliographical references and index
Contents
GENERAL OVERVIEW OF THE SAFETY EVALUATION OF CHEMICALS / Paul Illing -- Introduction -- Legislation and regulatory requirements -- The regulatory paradigm -- The interface between toxicology and risk assessment -- Interpreting toxicology -- Conclusions -- References -- INTERNATIONAL VALIDATION AND BARRIERS TO THE VALIDATION OF ALTERNATIVE TESTS / Michael Balls -- Introduction -- Background to the validation process -- The validation process -- Problems being encountered in implementing the validation process -- The need for an invalidation process -- Concluding remarks -- References -- IN VITRO TESTING FOR ENDOCRINE DISRUPTORS / Robert D. Combes -- Introduction -- In silico approaches -- In vitro tests for EDs -- Discussion -- Conclusions -- Acknowledgment -- References -- iNTELLIGENT APPROACHES TO SAFETY EVALUATION / Derek J. Knight -- Introduction -- Hazardous properties assessment -- Risk assessment -- Existing studies and literature data -- Surrogate data: calculation, read across and SAR/QSAR -- Alternatives to animal toxicology studies -- Data waivers -- Expert reports and weight of evidence -- Preliminary risk assessments -- EU Registration, Evaluation and Registration Scheme (REACH) -- Data for REACH -- Regulatory planning & liaison with the regulators -- Common themes -- Acknowledgments -- References -- ALTERNATIVE TESTS AND THE 7TH AMENDMENT TO THE COSMETICS DIRECTIVE / Carl Westmoreland -- Introduction -- Overview of current approaches to risk assessment for cosmetics -- 7th Amendment to the EU Cosmetics Directive (76/768/EEC) -- Status of alternative tests -- Endpoints where risk assessment for cosmetics can be achieved without using animal data -- Endpoints where risk assessment for cosmetics cannot currently be achieved without using animal data -- New approaches to risk assessment without animals -- Acknowledgments -- Abbreviations -- References
Control code
OCM1bookssj0000352631
Dimensions
unknown
Isbn
9780854042111
Lccn
2006494634
Specific material designation
remote
System control number
(WaSeSS)bookssj0000352631

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