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The Resource Angiogenesis, Thomas H. Adair, Jean-Pierre Montani, (electronic resource)

Angiogenesis, Thomas H. Adair, Jean-Pierre Montani, (electronic resource)

Creator
Contributor
Summary
Angiogenesis is the growth of blood vessels from the existing vasculature. The field of angiogenesis has grown enormously in the past 30 years, with only 40 papers published in 1980 and nearly 6000 in 2010. Why has there been this explosive growth in angiogenesis research? Angiogenic therapies provide a potential to conquer cancer, heart diseases, and more than 70 of life's most threatening medical conditions. The lives of at least 1 billion people worldwide could be improved with angiogenic therapy, according to the Angiogenesis Foundation. In this little book, we provide a simple approach to understand the essential elements of the angiogenic process, we critique the most powerful angiogenesis assays that are used to discover proangiogenic and antiangiogenic substances, and we provide an in-depth physiological perspective on how angiogenesis is regulated in normal, healthy tissues of the human body. All tissues of the body require a continuous supply of oxygen to burn metabolic substrates that are needed for energy. Oxygen is conducted to these tissues by blood capillaries: more capillaries can improve tissue oxygenation and thus enhance energy production; fewer capillaries can lead to hypoxia and even anoxia in the tissues. This means that angiogenic therapies designed to control the growth and regression of blood capillaries can be used to improve the survival of poorly perfused tissues that are essential to the body (heart, brain, skeletal muscle, etc.) and to rid the body of unwanted tissues (tumors)
Language
eng
Work
Publication
Extent
1 online resource (84 pages)
Note
  • Title from resource home page (NCBI Bookshelf, viewed July 12, 2011)
  • Part of: Colloquium digital library of life sciences
Isbn
9781615043316
Instance
Label
Angiogenesis
Title
Angiogenesis
Statement of responsibility
Thomas H. Adair, Jean-Pierre Montani
Creator
Contributor
Subject
Language
eng
Summary
Angiogenesis is the growth of blood vessels from the existing vasculature. The field of angiogenesis has grown enormously in the past 30 years, with only 40 papers published in 1980 and nearly 6000 in 2010. Why has there been this explosive growth in angiogenesis research? Angiogenic therapies provide a potential to conquer cancer, heart diseases, and more than 70 of life's most threatening medical conditions. The lives of at least 1 billion people worldwide could be improved with angiogenic therapy, according to the Angiogenesis Foundation. In this little book, we provide a simple approach to understand the essential elements of the angiogenic process, we critique the most powerful angiogenesis assays that are used to discover proangiogenic and antiangiogenic substances, and we provide an in-depth physiological perspective on how angiogenesis is regulated in normal, healthy tissues of the human body. All tissues of the body require a continuous supply of oxygen to burn metabolic substrates that are needed for energy. Oxygen is conducted to these tissues by blood capillaries: more capillaries can improve tissue oxygenation and thus enhance energy production; fewer capillaries can lead to hypoxia and even anoxia in the tissues. This means that angiogenic therapies designed to control the growth and regression of blood capillaries can be used to improve the survival of poorly perfused tissues that are essential to the body (heart, brain, skeletal muscle, etc.) and to rid the body of unwanted tissues (tumors)
Member of
Cataloging source
CaBNvSL
http://library.link/vocab/creatorName
Adair, Thomas H
Dewey number
612.13
Illustrations
illustrations
Index
no index present
LC call number
QP106.6
LC item number
.A322 2011
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
WG 500
NLM item number
A322a 2011
http://library.link/vocab/relatedWorkOrContributorDate
1951-
http://library.link/vocab/relatedWorkOrContributorName
Montani, Jean-Pierre
Series statement
Integrated systems physiology : from molecule to function to disease,
Series volume
#10
http://library.link/vocab/subjectName
  • Neovascularization, Pathologic
  • Neovascularization, Physiologic
  • Angiogenesis Inducing Agents
  • Angiogenesis Inhibitors
  • Biological Assay
  • Vascular Endothelial Growth Factors
Target audience
specialized
Label
Angiogenesis, Thomas H. Adair, Jean-Pierre Montani, (electronic resource)
Instantiates
Publication
Note
  • Title from resource home page (NCBI Bookshelf, viewed July 12, 2011)
  • Part of: Colloquium digital library of life sciences
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
686705781
Extent
1 online resource (84 pages)
Form of item
online
Isbn
9781615043316
Isbn Type
(electronic bk.)
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.4199/C00017ED1V01Y201009ISP010
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)686705781
Label
Angiogenesis, Thomas H. Adair, Jean-Pierre Montani, (electronic resource)
Publication
Note
  • Title from resource home page (NCBI Bookshelf, viewed July 12, 2011)
  • Part of: Colloquium digital library of life sciences
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
686705781
Extent
1 online resource (84 pages)
Form of item
online
Isbn
9781615043316
Isbn Type
(electronic bk.)
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.4199/C00017ED1V01Y201009ISP010
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)686705781

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