The Resource Antibody-drug conjugates, edited by Laurent Ducry
Antibody-drug conjugates, edited by Laurent Ducry
Resource Information
The item Antibody-drug conjugates, edited by Laurent Ducry represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Missouri Libraries.This item is available to borrow from 1 library branch.
Resource Information
The item Antibody-drug conjugates, edited by Laurent Ducry represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Missouri Libraries.
This item is available to borrow from 1 library branch.
- Summary
- Antibody-drug conjugates (ADCs) represent a promising therapeutic approach for cancer patients by combining the antigen-targeting specificity of monoclonal antibodies (mAbs) with the cytotoxic potency of chemotherapeutic drugs. In Antibody-Drug Conjugates, expert researchers provide detailed protocols for many of the key ADC techniques necessary for working in the field. These chapters and methodologies are aimed at the key tasks necessary to identify a suitable target, properly design the mAb, the linker and the payload, as well as to conjugate them in a reproducible and scalable fashion. Written in the highly successful Methods in Molecular Biology format, these detailed chapters include the kind of practical implementation advice that guarantees quality results. Authoritative and timely, Antibody-Drug Conjugates aims to further drive ADC development and thus help toward improving cancer treatments of the future
- Language
- eng
- Extent
- 1 online resource (x, 317 pages)
- Note
- Includes index
- Contents
-
- Antibody-Drug Conjugate (ADC) Clinical Pipeline: A Review
- Antibody-Drug Conjugate Target Selection: Critical Factors
- Selecting an Optimal Antibody for Antibody-Drug Conjugate Therapy: Internalization and Intracellular Localization
- Antibody-Drug Conjugate Payloads
- Linker Technologies for Antibody-Drug Conjugates
- In Vivo Testing of Drug-Linker Stability
- Pharmacokinetics and ADME Characterizations of Antibody-Drug Conjugates
- Safe Handling of Cytotoxic Compounds in a Biopharmaceutical Environment
- Micro- and Mid-Scale Maleimide-Based Conjugation of Cytotoxic Drugs to Antibody Hinge Region Thiols for Tumor Targeting
- Protocols for Lysine Conjugation
- Engineering THIOMABs for Site-Specific Conjugation of Thiol-Reactive Linkers
- Enzymatic Antibody Modification by Bacterial Transglutaminase
- Formulation Development of Antibody-Drug Conjugates
- Conjugation Process Development and Scale-Up
- Methods for Conjugating Antibodies to Nanocarriers
- Drug-to-Antibody Ratio (DAR) by UV/Vis Spectroscopy
- Drug-to-Antibody Ratio (DAR) and Drug Load Distribution by Hydrophobic Interaction Chromatography and Reversed Phase High Performance Liquid Chromatography
- Drug-to-Antibody Ratio (DAR) and Drug Load Distribution by LC-ESI-MS
- Determination of Charge Heterogeneity and Level of Unconjugated Antibody by Imaged cIEF
- Risk-Based Scientific Approach for Determination of Extractables/Leachables from Biomanufacturing of Antibody-Drug Conjugates (ADCs)
- Isbn
- 9781627035408
- Label
- Antibody-drug conjugates
- Title
- Antibody-drug conjugates
- Statement of responsibility
- edited by Laurent Ducry
- Subject
-
- Amino Acids, Peptides, and Proteins
- Antibodies
- Antibodies, Monoclonal
- Antibody-drug conjugates
- Antibody-drug conjugates -- Laboratory manuals
- Antibody-toxin conjugates
- Antibody-toxin conjugates -- Laboratory manuals
- Antineoplastic Agents
- Biology
- Blood Proteins
- Chemical Actions and Uses
- Disease
- Drug Combinations
- Globulins
- Health & Biological Sciences
- Immunoconjugates
- Immunoglobulins
- Immunoproteins
- Laboratory manuals
- Microbiology & Immunology
- Neoplasms
- Pharmaceutical Preparations
- Pharmacologic Actions
- Proteins
- Serum Globulins
- Therapeutic Uses
- Language
- eng
- Summary
- Antibody-drug conjugates (ADCs) represent a promising therapeutic approach for cancer patients by combining the antigen-targeting specificity of monoclonal antibodies (mAbs) with the cytotoxic potency of chemotherapeutic drugs. In Antibody-Drug Conjugates, expert researchers provide detailed protocols for many of the key ADC techniques necessary for working in the field. These chapters and methodologies are aimed at the key tasks necessary to identify a suitable target, properly design the mAb, the linker and the payload, as well as to conjugate them in a reproducible and scalable fashion. Written in the highly successful Methods in Molecular Biology format, these detailed chapters include the kind of practical implementation advice that guarantees quality results. Authoritative and timely, Antibody-Drug Conjugates aims to further drive ADC development and thus help toward improving cancer treatments of the future
- Cataloging source
- GW5XE
- Dewey number
- 615.3/7
- Illustrations
- illustrations
- Index
- index present
- Language note
- English
- LC call number
- RS201.A56
- Literary form
- non fiction
- Nature of contents
-
- dictionaries
- bibliography
- NLM call number
-
- W1
- QW 575.5.A6
- NLM item number
- ME9616J v.1045 2013
- http://library.link/vocab/relatedWorkOrContributorName
- Ducry, Laurent
- Series statement
- Methods in Molecular Biology,
- Series volume
- 1045
- http://library.link/vocab/subjectName
-
- Antibody-drug conjugates
- Antibody-toxin conjugates
- Immunoglobulins
- Disease
- Therapeutic Uses
- Immunoproteins
- Pharmacologic Actions
- Chemical Actions and Uses
- Serum Globulins
- Blood Proteins
- Globulins
- Proteins
- Amino Acids, Peptides, and Proteins
- Neoplasms
- Antibodies, Monoclonal
- Antineoplastic Agents
- Antibodies
- Immunoconjugates
- Drug Combinations
- Pharmaceutical Preparations
- Antibody-drug conjugates
- Antibody-toxin conjugates
- Biology
- Health & Biological Sciences
- Microbiology & Immunology
- Label
- Antibody-drug conjugates, edited by Laurent Ducry
- Note
- Includes index
- Antecedent source
- unknown
- Bibliography note
- Includes bibliographical references and index
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Color
- multicolored
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Contents
- Antibody-Drug Conjugate (ADC) Clinical Pipeline: A Review -- Antibody-Drug Conjugate Target Selection: Critical Factors -- Selecting an Optimal Antibody for Antibody-Drug Conjugate Therapy: Internalization and Intracellular Localization -- Antibody-Drug Conjugate Payloads -- Linker Technologies for Antibody-Drug Conjugates -- In Vivo Testing of Drug-Linker Stability -- Pharmacokinetics and ADME Characterizations of Antibody-Drug Conjugates -- Safe Handling of Cytotoxic Compounds in a Biopharmaceutical Environment -- Micro- and Mid-Scale Maleimide-Based Conjugation of Cytotoxic Drugs to Antibody Hinge Region Thiols for Tumor Targeting -- Protocols for Lysine Conjugation -- Engineering THIOMABs for Site-Specific Conjugation of Thiol-Reactive Linkers -- Enzymatic Antibody Modification by Bacterial Transglutaminase -- Formulation Development of Antibody-Drug Conjugates -- Conjugation Process Development and Scale-Up -- Methods for Conjugating Antibodies to Nanocarriers -- Drug-to-Antibody Ratio (DAR) by UV/Vis Spectroscopy -- Drug-to-Antibody Ratio (DAR) and Drug Load Distribution by Hydrophobic Interaction Chromatography and Reversed Phase High Performance Liquid Chromatography -- Drug-to-Antibody Ratio (DAR) and Drug Load Distribution by LC-ESI-MS -- Determination of Charge Heterogeneity and Level of Unconjugated Antibody by Imaged cIEF -- Risk-Based Scientific Approach for Determination of Extractables/Leachables from Biomanufacturing of Antibody-Drug Conjugates (ADCs)
- Control code
- 857143002
- Dimensions
- unknown
- Extent
- 1 online resource (x, 317 pages)
- File format
- unknown
- Form of item
- online
- Isbn
- 9781627035408
- Level of compression
- unknown
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Other control number
- 10.1007/978-1-62703-541-5
- Other physical details
- illustrations.
- Quality assurance targets
- not applicable
- Reformatting quality
- unknown
- Sound
- unknown sound
- Specific material designation
- remote
- System control number
- (OCoLC)857143002
- Label
- Antibody-drug conjugates, edited by Laurent Ducry
- Note
- Includes index
- Antecedent source
- unknown
- Bibliography note
- Includes bibliographical references and index
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Color
- multicolored
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Contents
- Antibody-Drug Conjugate (ADC) Clinical Pipeline: A Review -- Antibody-Drug Conjugate Target Selection: Critical Factors -- Selecting an Optimal Antibody for Antibody-Drug Conjugate Therapy: Internalization and Intracellular Localization -- Antibody-Drug Conjugate Payloads -- Linker Technologies for Antibody-Drug Conjugates -- In Vivo Testing of Drug-Linker Stability -- Pharmacokinetics and ADME Characterizations of Antibody-Drug Conjugates -- Safe Handling of Cytotoxic Compounds in a Biopharmaceutical Environment -- Micro- and Mid-Scale Maleimide-Based Conjugation of Cytotoxic Drugs to Antibody Hinge Region Thiols for Tumor Targeting -- Protocols for Lysine Conjugation -- Engineering THIOMABs for Site-Specific Conjugation of Thiol-Reactive Linkers -- Enzymatic Antibody Modification by Bacterial Transglutaminase -- Formulation Development of Antibody-Drug Conjugates -- Conjugation Process Development and Scale-Up -- Methods for Conjugating Antibodies to Nanocarriers -- Drug-to-Antibody Ratio (DAR) by UV/Vis Spectroscopy -- Drug-to-Antibody Ratio (DAR) and Drug Load Distribution by Hydrophobic Interaction Chromatography and Reversed Phase High Performance Liquid Chromatography -- Drug-to-Antibody Ratio (DAR) and Drug Load Distribution by LC-ESI-MS -- Determination of Charge Heterogeneity and Level of Unconjugated Antibody by Imaged cIEF -- Risk-Based Scientific Approach for Determination of Extractables/Leachables from Biomanufacturing of Antibody-Drug Conjugates (ADCs)
- Control code
- 857143002
- Dimensions
- unknown
- Extent
- 1 online resource (x, 317 pages)
- File format
- unknown
- Form of item
- online
- Isbn
- 9781627035408
- Level of compression
- unknown
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Other control number
- 10.1007/978-1-62703-541-5
- Other physical details
- illustrations.
- Quality assurance targets
- not applicable
- Reformatting quality
- unknown
- Sound
- unknown sound
- Specific material designation
- remote
- System control number
- (OCoLC)857143002
Subject
- Amino Acids, Peptides, and Proteins
- Antibodies
- Antibodies, Monoclonal
- Antibody-drug conjugates
- Antibody-drug conjugates -- Laboratory manuals
- Antibody-toxin conjugates
- Antibody-toxin conjugates -- Laboratory manuals
- Antineoplastic Agents
- Biology
- Blood Proteins
- Chemical Actions and Uses
- Disease
- Drug Combinations
- Globulins
- Health & Biological Sciences
- Immunoconjugates
- Immunoglobulins
- Immunoproteins
- Laboratory manuals
- Microbiology & Immunology
- Neoplasms
- Pharmaceutical Preparations
- Pharmacologic Actions
- Proteins
- Serum Globulins
- Therapeutic Uses
Genre
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<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.library.missouri.edu/portal/Antibody-drug-conjugates-edited-by-Laurent/5Gy5jbTqu0Y/" typeof="Book http://bibfra.me/vocab/lite/Item"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.library.missouri.edu/portal/Antibody-drug-conjugates-edited-by-Laurent/5Gy5jbTqu0Y/">Antibody-drug conjugates, edited by Laurent Ducry</a></span> - <span property="potentialAction" typeOf="OrganizeAction"><span property="agent" typeof="LibrarySystem http://library.link/vocab/LibrarySystem" resource="http://link.library.missouri.edu/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.library.missouri.edu/">University of Missouri Libraries</a></span></span></span></span></div>
