Coverart for item
The Resource Apoptosis in cancer pathogenesis and anti-cancer therapy : new perspectives and opportunities, Christopher D. Gregory, editor

Apoptosis in cancer pathogenesis and anti-cancer therapy : new perspectives and opportunities, Christopher D. Gregory, editor

Label
Apoptosis in cancer pathogenesis and anti-cancer therapy : new perspectives and opportunities
Title
Apoptosis in cancer pathogenesis and anti-cancer therapy
Title remainder
new perspectives and opportunities
Statement of responsibility
Christopher D. Gregory, editor
Contributor
Editor
Subject
Genre
Language
eng
Summary
This book discusses properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment. Its nine chapters discuss modulation of anti-tumor inflammatory and immune responses, effects on the tumor microenvironment, to strategies for improving pro-apoptotic therapies, mechanisms and implications for disease pathogenesis, axl and mer receptor tyrosine kinases, immunogenic apoptotic cell death and anti-cancer immunity and cancer cell death-inducing radiotherapy. This book places the onco-biology of apoptosis in clear and objective perspective through an expertly synthesized series of reviews. Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy is a deft and thorough exploration of cutting-edge research in apoptosis and anti-cancer mechanisms from basic biology to oncology. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike
Member of
Cataloging source
N$T
Dewey number
571.9/36
Illustrations
illustrations
Index
index present
LC call number
QH671
Literary form
non fiction
Nature of contents
dictionaries
NLM call number
QU 375
http://library.link/vocab/relatedWorkOrContributorName
Gregory, Christopher D.
Series statement
Advances in experimental medicine and biology,
Series volume
930
http://library.link/vocab/subjectName
  • Apoptosis
  • Cancer
  • Apoptosis
  • Neoplasms
  • SCIENCE
  • Apoptosis
  • Cancer
Label
Apoptosis in cancer pathogenesis and anti-cancer therapy : new perspectives and opportunities, Christopher D. Gregory, editor
Instantiates
Publication
Note
Includes index
Antecedent source
unknown
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Foreword; Preface; Acknowledgements; Contents; Contributors; Chapter 1: Molecular Cell Biology of€Apoptosis and€Necroptosis in€Cancer; 1.1 Introduction; 1.2 Role of€Cell Death Pathways in€Cancer Suppression; 1.3 Apoptosis; 1.3.1 Caspases and€Cell Death; 1.3.2 Intrinsic Cell Death; 1.3.2.1 Mechanisms of€Caspase-9-Mediated Apoptosis; 1.3.2.2 Physiological Functions of€the€Mitochondrial Apoptotic Pathway; 1.3.2.3 Mitochondrial Apoptotic Pathway in€Cancer and€Cancer Therapy; 1.3.2.4 Mechanisms of€Caspase-2-Mediated Apoptosis; 1.3.2.5 Physiological Functions of€the€Caspase-2 Apoptosis Pathway
  • 1.3.2.6 Caspase-2-Mediated Apoptosis in€Cancer and€Cancer Therapy1.3.3 Extrinsic Cell Death; 1.3.3.1 Physiological Functions of€the€Caspase-8 Apoptosis Pathway; 1.3.3.2 Caspase-8-Mediated Apoptosis in€Cancer and€Cancer Therapy; 1.3.4 RIPK-Mediated Necroptosis: A€New Target for€Tumor Therapy?; 1.3.4.1 Mechanisms of€Necroptosis; 1.3.4.2 Physiological Role of€RIPK-Mediated Necroptosis; 1.3.4.3 Necroptosis in€Cancer and€Cancer Therapy; 1.3.5 Perspectives; References; Chapter 2: Clearance of€Dying Cells by Phagocytes: Mechanisms and€Implications for€Disease Pathogenesis; 2.1 Introduction
  • 2.2 Types of€Apoptotic Cells and€Phagocytes2.3 Steps in€Apoptotic Cell Engulfment; 2.3.1 Find-Me Signals; 2.3.2 Eat-Me Signals; 2.3.3 The Engulfment Receptors and€Bridging Molecules; 2.3.4 Intracellular Signaling in€the€Phagocyte; 2.4 Effects of€Apoptotic Cell Clearance; 2.4.1 Induction of€an€Anti-inflammatory Program; 2.4.2 Suppression of€Proinflammatory Signals; 2.5 Defective Apoptotic Cell Clearance and€Inflammatory Disease; 2.5.1 Autoimmunity; 2.5.2 Airway Inflammation; 2.5.3 Inflammatory Colitis; 2.6 Phagocytes, Anti-inflammatory Responses, and€Cancer Context
  • 2.6.1 Phagocytic Signaling Pathways in€a€Malignant Tissue2.6.2 BAI1; 2.6.3 ELMO1; 2.6.4 Pannexin Channels; 2.6.5 MER Tyrosine Kinase; 2.7 Concluding Thoughts; References; Chapter 3: Microenvironmental Effects of€Cell Death in€Malignant Disease; 3.1 Introduction: Imbalances of€Cell Birth and€Cell Death in€Cancer; 3.2 A Poisoned Chalice: Tumor-Promoting as€well as Tumor-ƯSuppressing Roles of€Apoptosis; 3.3 Cell Death Modalities Influencing the€Tumor Microenvironment: Apoptosis and€Other Mechanisms; 3.3.1 Triggering of€Apoptosis in Growing Tumors; 3.3.2 Necrosis, Autophagy, and€Other Mechanisms
  • 3.4 Biological Activities of€Apoptotic Tumor Cells3.4.1 Mechanisms; 3.4.2 Activities of€Stressed Cells Versus Dying Cells; 3.5 Responses to€Cell Death in€the€Tumor Microenvironment; 3.6 Apoptosis and€Angiogenesis: The€Effects of€Hypoxia; 3.7 Apoptosis and€Tissue Repair Mechanisms in€Cancer: The€"Onco-Regenerative Niche"; 3.8 Opportunities for€Improving Cancer Treatment; 3.9 Conclusions and€Future Perspectives; References; Chapter 4: Apoptotic Caspases in€Promoting Cancer: Implications from€Their Roles in€Development and€Tissue Homeostasis; 4.1 Introduction
Control code
MUHSLdda957464795
Dimensions
unknown
Extent
1 online resource (xvii, 247 pages)
File format
unknown
Form of item
online
Isbn
9783319394060
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (some color).
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)957464795
Label
Apoptosis in cancer pathogenesis and anti-cancer therapy : new perspectives and opportunities, Christopher D. Gregory, editor
Publication
Note
Includes index
Antecedent source
unknown
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Foreword; Preface; Acknowledgements; Contents; Contributors; Chapter 1: Molecular Cell Biology of€Apoptosis and€Necroptosis in€Cancer; 1.1 Introduction; 1.2 Role of€Cell Death Pathways in€Cancer Suppression; 1.3 Apoptosis; 1.3.1 Caspases and€Cell Death; 1.3.2 Intrinsic Cell Death; 1.3.2.1 Mechanisms of€Caspase-9-Mediated Apoptosis; 1.3.2.2 Physiological Functions of€the€Mitochondrial Apoptotic Pathway; 1.3.2.3 Mitochondrial Apoptotic Pathway in€Cancer and€Cancer Therapy; 1.3.2.4 Mechanisms of€Caspase-2-Mediated Apoptosis; 1.3.2.5 Physiological Functions of€the€Caspase-2 Apoptosis Pathway
  • 1.3.2.6 Caspase-2-Mediated Apoptosis in€Cancer and€Cancer Therapy1.3.3 Extrinsic Cell Death; 1.3.3.1 Physiological Functions of€the€Caspase-8 Apoptosis Pathway; 1.3.3.2 Caspase-8-Mediated Apoptosis in€Cancer and€Cancer Therapy; 1.3.4 RIPK-Mediated Necroptosis: A€New Target for€Tumor Therapy?; 1.3.4.1 Mechanisms of€Necroptosis; 1.3.4.2 Physiological Role of€RIPK-Mediated Necroptosis; 1.3.4.3 Necroptosis in€Cancer and€Cancer Therapy; 1.3.5 Perspectives; References; Chapter 2: Clearance of€Dying Cells by Phagocytes: Mechanisms and€Implications for€Disease Pathogenesis; 2.1 Introduction
  • 2.2 Types of€Apoptotic Cells and€Phagocytes2.3 Steps in€Apoptotic Cell Engulfment; 2.3.1 Find-Me Signals; 2.3.2 Eat-Me Signals; 2.3.3 The Engulfment Receptors and€Bridging Molecules; 2.3.4 Intracellular Signaling in€the€Phagocyte; 2.4 Effects of€Apoptotic Cell Clearance; 2.4.1 Induction of€an€Anti-inflammatory Program; 2.4.2 Suppression of€Proinflammatory Signals; 2.5 Defective Apoptotic Cell Clearance and€Inflammatory Disease; 2.5.1 Autoimmunity; 2.5.2 Airway Inflammation; 2.5.3 Inflammatory Colitis; 2.6 Phagocytes, Anti-inflammatory Responses, and€Cancer Context
  • 2.6.1 Phagocytic Signaling Pathways in€a€Malignant Tissue2.6.2 BAI1; 2.6.3 ELMO1; 2.6.4 Pannexin Channels; 2.6.5 MER Tyrosine Kinase; 2.7 Concluding Thoughts; References; Chapter 3: Microenvironmental Effects of€Cell Death in€Malignant Disease; 3.1 Introduction: Imbalances of€Cell Birth and€Cell Death in€Cancer; 3.2 A Poisoned Chalice: Tumor-Promoting as€well as Tumor-ƯSuppressing Roles of€Apoptosis; 3.3 Cell Death Modalities Influencing the€Tumor Microenvironment: Apoptosis and€Other Mechanisms; 3.3.1 Triggering of€Apoptosis in Growing Tumors; 3.3.2 Necrosis, Autophagy, and€Other Mechanisms
  • 3.4 Biological Activities of€Apoptotic Tumor Cells3.4.1 Mechanisms; 3.4.2 Activities of€Stressed Cells Versus Dying Cells; 3.5 Responses to€Cell Death in€the€Tumor Microenvironment; 3.6 Apoptosis and€Angiogenesis: The€Effects of€Hypoxia; 3.7 Apoptosis and€Tissue Repair Mechanisms in€Cancer: The€"Onco-Regenerative Niche"; 3.8 Opportunities for€Improving Cancer Treatment; 3.9 Conclusions and€Future Perspectives; References; Chapter 4: Apoptotic Caspases in€Promoting Cancer: Implications from€Their Roles in€Development and€Tissue Homeostasis; 4.1 Introduction
Control code
MUHSLdda957464795
Dimensions
unknown
Extent
1 online resource (xvii, 247 pages)
File format
unknown
Form of item
online
Isbn
9783319394060
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (some color).
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)957464795

Library Locations

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      1 Hospital Dr, Columbia, MO, 65201, US
      38.939544 -92.328377
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