The Resource Applications of the opto-fluidic ring resonator for DNA methylation analysis and microfluidic laser development, by Jonathan D. Suter, (electronic resource)

Applications of the opto-fluidic ring resonator for DNA methylation analysis and microfluidic laser development, by Jonathan D. Suter, (electronic resource)

Label
Applications of the opto-fluidic ring resonator for DNA methylation analysis and microfluidic laser development
Title
Applications of the opto-fluidic ring resonator for DNA methylation analysis and microfluidic laser development
Statement of responsibility
by Jonathan D. Suter
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
For several decades, optical ring resonators have played an important role in the field of telecommunications. Within only the past decade however, ring resonators have been applied for the purposes of biological and chemical detection by means of refractometric signal transduction. The advantage of ring resonator-based sensing is that, unlike fluorescence detection, it is label-free and can yield quantitative data. This document presents the fundamental operation of the versatile opto-fluidic ring resonator (OFRR) and explores its applications in DNA methylation analysis. Using affinity assays based on anti-5-methyl cytosine antibodies as well as the methyl binding protein MBD-2, it is shown that the OFRR is a promising tool for biomedical research that can discriminate the extent of DNA methylation. As a part of evolving this and other devices towards a practical laboratory and clinical tool, it is important to consider methods for integrating optical functionality onto a compact chip. Towards this end, we also investigate the ability of PDMS-based ring resonators to provide tunable on-chip microfluidic lasers. This idea is explored by looking at two different ring geometries. Very low lasing thresholds are demonstrated
Cataloging source
MUU
http://library.link/vocab/creatorDate
1982-
http://library.link/vocab/creatorName
Suter, Jonathan Daniel
Degree
Ph. D.
Dissertation year
2010.
Granting institution
University of Missouri--Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
Fan, Xudong
http://library.link/vocab/subjectName
  • Optofluidics
  • Resonators
  • DNA
  • Microfluidics
  • Lasers
  • Cellular signal transduction
Target audience
specialized
Label
Applications of the opto-fluidic ring resonator for DNA methylation analysis and microfluidic laser development, by Jonathan D. Suter, (electronic resource)
Instantiates
Publication
Note
  • Title from PDF of title page (University of Missouri--Columbia, viewed on December 7, 2010)
  • The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file
  • Dissertation advisor: Dr. Xudong Fan
  • Vita
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
706833713
Extent
1 online resource (xvi, 155 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)706833713
Label
Applications of the opto-fluidic ring resonator for DNA methylation analysis and microfluidic laser development, by Jonathan D. Suter, (electronic resource)
Publication
Note
  • Title from PDF of title page (University of Missouri--Columbia, viewed on December 7, 2010)
  • The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file
  • Dissertation advisor: Dr. Xudong Fan
  • Vita
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
706833713
Extent
1 online resource (xvi, 155 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)706833713

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