The Resource Arsenic for potential diagnostic imaging and radiotherapy, by Anthony James Degraffenreid

Arsenic for potential diagnostic imaging and radiotherapy, by Anthony James Degraffenreid

Label
Arsenic for potential diagnostic imaging and radiotherapy
Title
Arsenic for potential diagnostic imaging and radiotherapy
Statement of responsibility
by Anthony James Degraffenreid
Creator
Contributor
Author
Thesis advisor
Subject
Genre
Language
eng
Summary
Targeted agents hold promise for non-invasive in vivo imaging, therapy, and monitoring of diseases. Foundational work focused on imaging and therapy of cancer has centered primarily on the use of 18F, 90Y, 99mTc, and 131I radionuclides. Use of these agents often requires conjugation to a biological targeting vector, a peptide or monoclonal antibody, to investigate biological processes. However, to truly be effective, the physical properties of the radionuclide must be suitably matched to the time required for chemical derivatization, and conjugation, to reach maximal uptake of the targeting vector at the targeting site. Radioisotopes of arsenic, 72, 77As, have sufficiently long halflives that are well-matched for conjugation to these biological targeting vectors. Even with favorable decay characteristics, production, and separation pathways, the ability to use radioarsenic has largely remained undeveloped. It is the aim of this work to address this issue through the identification and synthesis of no-carrier added radioarsenic complexes. Macroscopic synthesis of AsPh(S-Rn-S) precursors to no-carrier added 72,77AsPh(S-Rn-S) complexes, synthesis and no-carrier added radioarsenic labelling of a simple trithiol ligand, and synthesis of two linkable trithiocyanate precursors, a carboxylic acid, and 2clickable3 alkyne, are described in detail. Other topics that will be discussed in brief and can be found in the attached appendices are as follows: initial development of a radiochemical separation procedure to separate no-carrier arsenic, 77As, from a neutron irradiated germanium dioxide target, the initial evaluation of a novel copper selective resin, and synthesis of any additional compounds not mentioned in the chapters
Cataloging source
MUU
http://library.link/vocab/creatorDate
1987-
http://library.link/vocab/creatorName
DeGraffenreid, Anthony James
Degree
PhD
Dissertation note
Thesis
Dissertation year
2015.
Government publication
government publication of a state province territory dependency etc
Granting institution
University of Missouri--Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
Jurisson, Silvia S.
http://library.link/vocab/subjectName
  • Arsenic
  • Diagnostic imaging
  • Radiotherapy
  • Tomography, Emission
Label
Arsenic for potential diagnostic imaging and radiotherapy, by Anthony James Degraffenreid
Instantiates
Publication
Copyright
Note
  • "A Dissertation presented to the Faculty of the Graduate School at the University of Missouri-Columbia In partial fulfillment of the requirements for the degree Doctor of Philosophy."
  • Dissertation supervisor: Dr. Silvia S. Jurisson
  • Includes vita
Bibliography note
Includes bibliographical references (pages 328-336)
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
958883588
Extent
1 online resource (xxi, 337 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations (some color)
Specific material designation
remote
System control number
(OCoLC)958883588
Label
Arsenic for potential diagnostic imaging and radiotherapy, by Anthony James Degraffenreid
Publication
Copyright
Note
  • "A Dissertation presented to the Faculty of the Graduate School at the University of Missouri-Columbia In partial fulfillment of the requirements for the degree Doctor of Philosophy."
  • Dissertation supervisor: Dr. Silvia S. Jurisson
  • Includes vita
Bibliography note
Includes bibliographical references (pages 328-336)
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
958883588
Extent
1 online resource (xxi, 337 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations (some color)
Specific material designation
remote
System control number
(OCoLC)958883588

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