The Resource Azelnidipine attenuates inflammatory responses, superoxide and relevant signaling pathways induced by amyloid-beta in mouse cerebral endothelial cells, by Tao Teng

Azelnidipine attenuates inflammatory responses, superoxide and relevant signaling pathways induced by amyloid-beta in mouse cerebral endothelial cells, by Tao Teng

Label
Azelnidipine attenuates inflammatory responses, superoxide and relevant signaling pathways induced by amyloid-beta in mouse cerebral endothelial cells
Title
Azelnidipine attenuates inflammatory responses, superoxide and relevant signaling pathways induced by amyloid-beta in mouse cerebral endothelial cells
Statement of responsibility
by Tao Teng
Creator
Contributor
Author
Thesis advisor
Subject
Genre
Language
eng
Summary
Alzheimer's disease (AD) is a debilitating neurodegenerative disease with no known cure. The cause and progression of AD is still unclear. Over the years, studies have shown that one of the earliest cytotoxic effects is the production of reactive oxygen species (ROS) and inflammation induced by the amyloid-beta peptide in microglial cells, endothelial cells and neurons. The focus of this thesis is to study the effects of Azelnidipine (ALP), which is a Calcium channel blocker, on Abeta-induced oxidative stress and its downstream pathways in mouse immortalized cerebral endothelial cells (bEnd.3). In AD, Abeta 1-42 induces oxidative stress through the activation of ERK 1/2 pathway, phosphorylation of cPLA2 and production of intercellular superoxide anions. Furthermore, Abeta42 has been shown to induce the translocation of NF-kappaB into the nucleus of bEnd.3 cells causing an inflammatory response. Here, ALP is utilized to reduce the ROS and inflammatory effects of A?42 in bEnd.3 cells. The results show that ALP is effective in reducing the Abeta42 induced superoxide anion production, ERK 1/2 activation, cPLA2 phosphorylation and NF-kappaB translocation into the nucleus of bEnd.3 cells. Thus, ALP may be an effective treatment to alleviate the debilitating effects of AD. Finally, this research implicates that there may be cross-talk between the ERK 1/2 pathway and NF-kappaB translocation into the bEnd.3 nucleus
Cataloging source
MUU
http://library.link/vocab/creatorName
Teng, Tao
Degree
M.S.
Dissertation note
Thesis
Dissertation year
2014.
Government publication
government publication of a state province territory dependency etc
Granting institution
University of Missouri--Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
Lee, James C-M.
http://library.link/vocab/subjectName
  • Alzheimer's disease
  • Active oxygen
  • Bioengineering
Label
Azelnidipine attenuates inflammatory responses, superoxide and relevant signaling pathways induced by amyloid-beta in mouse cerebral endothelial cells, by Tao Teng
Instantiates
Publication
Note
Dr. James C-M. Lee, Thesis Supervisor
Bibliography note
Includes bibliographical references (pages 52-65)
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
987620109
Extent
1 online resource (vii, 65 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations
Specific material designation
remote
System control number
(OCoLC)987620109
Label
Azelnidipine attenuates inflammatory responses, superoxide and relevant signaling pathways induced by amyloid-beta in mouse cerebral endothelial cells, by Tao Teng
Publication
Note
Dr. James C-M. Lee, Thesis Supervisor
Bibliography note
Includes bibliographical references (pages 52-65)
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
987620109
Extent
1 online resource (vii, 65 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations
Specific material designation
remote
System control number
(OCoLC)987620109

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