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The Resource CFTR chloride channels and ABC active transporters undergo similar structural rearrangements as part of their operation

CFTR chloride channels and ABC active transporters undergo similar structural rearrangements as part of their operation

Label
CFTR chloride channels and ABC active transporters undergo similar structural rearrangements as part of their operation
Title
CFTR chloride channels and ABC active transporters undergo similar structural rearrangements as part of their operation
Creator
Author
Subject
Language
eng
Summary
Defects in the cystic fibrosis transmembrane conductance regulator (CFTR) underlie the lethal genetic disease cystic fibrosis. Although CFTR belongs to the ATP-binding cassette (ABC) transporter superfamily, it functions as a phosphorylation-and ATP-regulated chloride channel. The molecular architecture of CFTR encompasses two cytosolic nucleotide-binding domains (NBD1 and NBD2), two transmembrane domains (TMD1 and TMD2) and a regulatory (R) domain. Here, I adopted the cysteine scanning method to study two transmembrane segments (TM6 and TM12) of CFTR. Major findings are that (i) like other ABC proteins, both TM6 and TM12 of CFTR are Ü-elical and contribute to the lining of the permeation pathway, (ii) gating conformational changes in CFTR and structural rearrangements associated with the transport cycle of ABC exporters share analogous features in that both involve flip-flop motion in the TMDs and helical rotation in the TMs, and (iii) there is no physical gate at the cytoplasmic entrance of the CFTR channel. Collectively, these findings agree satisfactorily with the long-held hypothesis that the CFTR channel lacks the cytoplasmic-side gate of a primordial ABC exporter
Cataloging source
MUU
http://library.link/vocab/creatorName
Bai, Yonghong
Degree
Ph. D.
Dissertation note
Thesis
Dissertation year
2012.
Government publication
government publication of a state province territory dependency etc
Granting institution
University of Missouri--Columbia,
Index
no index present
Literary form
non fiction
Nature of contents
dictionaries
Label
CFTR chloride channels and ABC active transporters undergo similar structural rearrangements as part of their operation
Instantiates
Publication
Contributor
Thesis advisor
Note
Advisor: Tzyh-Chang Hwang
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
txt
Content type MARC source
rdacontent.
Control code
872568719
Extent
1 online resource (xi, 152 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
c
Specific material designation
remote
System control number
(OCoLC)872568719
Label
CFTR chloride channels and ABC active transporters undergo similar structural rearrangements as part of their operation
Publication
Contributor
Thesis advisor
Note
Advisor: Tzyh-Chang Hwang
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
txt
Content type MARC source
rdacontent.
Control code
872568719
Extent
1 online resource (xi, 152 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
c
Specific material designation
remote
System control number
(OCoLC)872568719

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