Coverart for item
The Resource CPLA2 : key enzyme for astrocytic cell membrane phase property change induced by abeta, by Yinzhi Lai, (electronic resource)

CPLA2 : key enzyme for astrocytic cell membrane phase property change induced by abeta, by Yinzhi Lai, (electronic resource)

Label
CPLA2 : key enzyme for astrocytic cell membrane phase property change induced by abeta
Title
CPLA2
Title remainder
key enzyme for astrocytic cell membrane phase property change induced by abeta
Statement of responsibility
by Yinzhi Lai
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
The interaction of amyloid beta peptide (A [beta]) and cell membrane is believed to be the basis of its biological function including its toxicity to neurons, thus it is important to understand how A [beta] affects cell membrane properties. Contradictory observations have been reported on A [beta]'s effect on membrane fluidity, possibly resulted from different target samples, distinct A [beta] types, A [beta] preparation procedure, various incubation time length and diverse testing techniques applied. Among all these variables, we suspect A [beta] treatment time length to be one of the most important factors that will affect the effect of A [beta] on cell membrane. Here, we reported an interesting time-dependent biphasic change pattern of DITNC cell membrane phase properties induced by oligomeric A [beta] 1−42. A novel membrane phase property marker - Laurdan was applied in our study to reveal not only the overall membrane phase changes but also specific local membrane phase properties. The role of phospholipase A2 (PLA2) in the membrane phase property changes induced by oligomeric A [beta]1−42 has also been tested. Based on our experimental results, a model was proposed to explain the time dependent biphasic membrane phase property change phenomenon and how A[beta] affects cell membrane phase properties
Cataloging source
MUU
http://library.link/vocab/creatorName
Lai, Yinzhi
Degree
M.S.
Dissertation year
2007.
Granting institution
University of Missouri-Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • abstracts summaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
Lee, James C-M
http://library.link/vocab/subjectName
  • Peptides
  • Amyloid beta-protein
  • Phospholipase A2
  • Cell membranes
Target audience
specialized
Label
CPLA2 : key enzyme for astrocytic cell membrane phase property change induced by abeta, by Yinzhi Lai, (electronic resource)
Instantiates
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from title screen of research.pdf file (viewed on April 14, 2008)
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
mixed
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
223950215
Dimensions
unknown
Form of item
electronic
Governing access note
Access is limited to the campus of the University of Missouri-Columbia
Media category
computer
Media MARC source
rdamedia
Media type code
c
Specific material designation
remote
System control number
(OCoLC)223950215
System details
Mode of access: World Wide Web
Terms governing use
Access is limited to the campus of the University of Missouri-Columbia.
Label
CPLA2 : key enzyme for astrocytic cell membrane phase property change induced by abeta, by Yinzhi Lai, (electronic resource)
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from title screen of research.pdf file (viewed on April 14, 2008)
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
mixed
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
223950215
Dimensions
unknown
Form of item
electronic
Governing access note
Access is limited to the campus of the University of Missouri-Columbia
Media category
computer
Media MARC source
rdamedia
Media type code
c
Specific material designation
remote
System control number
(OCoLC)223950215
System details
Mode of access: World Wide Web
Terms governing use
Access is limited to the campus of the University of Missouri-Columbia.

Library Locations

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