The Resource Characterization of the organic matrix of mature human tooth enamel : structure, macromolecular composition and effect of radiotherapy, Jacob D. McGuire

Characterization of the organic matrix of mature human tooth enamel : structure, macromolecular composition and effect of radiotherapy, Jacob D. McGuire

Label
Characterization of the organic matrix of mature human tooth enamel : structure, macromolecular composition and effect of radiotherapy
Title
Characterization of the organic matrix of mature human tooth enamel
Title remainder
structure, macromolecular composition and effect of radiotherapy
Statement of responsibility
Jacob D. McGuire
Creator
Contributor
Author
Degree supervisor
Subject
Genre
Language
eng
Summary
Mature human tooth enamel contains a small amount of organic matrix locally concentrated within its innermost region, which is tougher and more crack resistant than the outer bulk phase. Although the enamel organic matrix is regarded to contribute to these properties, its structure and macromolecular composition remain largely unknown. To characterize these unknowns, the hypotheses tested were, 2The organic matrix of mature human tooth enamel is comprised of a well-organized network of proteins; that the epithelial-derived organic matrix of mature human tooth enamel contains type VII and type IV collagen; and that radiotherapy affects the ultrastructure and type VII and type IV collagen components of the organic matrix of mature human tooth enamel.3 To achieve these goals, three aims were addressed: 1) To characterize the distribution and ultrastructure of the organic matrix of mature human tooth enamel using multiple techniques; 2) To identify and localize macromolecular components of the organic matrix of mature human tooth enamel; and 3) To characterize the ultrastructure and collagenous components of the organic matrix of mature human tooth enamel subsequent to in vitro and in vivo radiotherapy. Results of these studies were as follows. First, the organic matrix of mature human tooth enamel was distributed within enamel{u2019}s inner region in proportion to the thickness of the anatomical enamel layer; and was composed of a meshwork of integrated protein fibrils reflective of the rod/interrod and aprismatic morphology of the surrounding inorganic phase. Second, the enamel organic matrix, for the first time, was shown to contain type VII collagen and collagen IV; each of which exhibit a unique distribution pattern relative to the DEJ. Third, though the enamel organic matrix was not directly affected by simulated in vitro radiotherapy, enamel-matrix type IV collagen was affected in teeth exposed to in vivo radiotherapy. Further testing of teeth exposed to in vivo radiotherapy is required. We hypothesize that the results of these studies will help define the unique material properties of inner enamel, and further the identification and characterization of other macromolecular components of the enamel organic matrix at the DEJ
Cataloging source
UMK
http://library.link/vocab/creatorName
McGuire, Jacob D
Degree
Ph.D.
Dissertation note
(School of Dentistry and School of Pharmacy).
Dissertation year
2014.
Granting institution
University of Missouri-Kansas City,
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
  • Walker, Mary P.
  • Wang, Yong
http://library.link/vocab/subjectName
  • Dental enamel
  • Radiotherapy
  • Dental Enamel
  • Radiotherapy
Label
Characterization of the organic matrix of mature human tooth enamel : structure, macromolecular composition and effect of radiotherapy, Jacob D. McGuire
Instantiates
Publication
Note
  • "A dissertation in Oral and Craniofacial Sciences and Pharmacology."
  • Advisors: Mary P. Walker and Yong Wang
  • Vita
Antecedent source
not applicable
Bibliography note
Includes bibliographical references (pages 128-145)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
black and white
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Introduction -- Background -- Characterization of the distribution and ultrastructure of the organic matrix of mature human tooth enamel -- Type VII collagen in enriched in the enamel organic matrix associated with the dentin-enamel junction of mature human teeth -- Type IV collagen is a component of the enamel organic matrix localized in the dentin-enamel junction of mature human teeth -- The effect of in vitro and in vivo radiotheraphy on the organic matrix of mature human tooth enamel -- Conclusions
Control code
949855954
Dimensions
unknown
Extent
1 online resource (148 pages)
File format
one file format
Form of item
online
Level of compression
mixed
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations.
Quality assurance targets
not applicable
Specific material designation
remote
System control number
(OCoLC)949855954
System details
  • The full text of the dissertation is available as an Adobe Acrobat .pdf file; Adobe Acrobat Reader required to view the file
  • Mode of access: World Wide Web
Label
Characterization of the organic matrix of mature human tooth enamel : structure, macromolecular composition and effect of radiotherapy, Jacob D. McGuire
Publication
Note
  • "A dissertation in Oral and Craniofacial Sciences and Pharmacology."
  • Advisors: Mary P. Walker and Yong Wang
  • Vita
Antecedent source
not applicable
Bibliography note
Includes bibliographical references (pages 128-145)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
black and white
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Introduction -- Background -- Characterization of the distribution and ultrastructure of the organic matrix of mature human tooth enamel -- Type VII collagen in enriched in the enamel organic matrix associated with the dentin-enamel junction of mature human teeth -- Type IV collagen is a component of the enamel organic matrix localized in the dentin-enamel junction of mature human teeth -- The effect of in vitro and in vivo radiotheraphy on the organic matrix of mature human tooth enamel -- Conclusions
Control code
949855954
Dimensions
unknown
Extent
1 online resource (148 pages)
File format
one file format
Form of item
online
Level of compression
mixed
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations.
Quality assurance targets
not applicable
Specific material designation
remote
System control number
(OCoLC)949855954
System details
  • The full text of the dissertation is available as an Adobe Acrobat .pdf file; Adobe Acrobat Reader required to view the file
  • Mode of access: World Wide Web

Library Locations

  • Ellis LibraryBorrow it
    1020 Lowry Street, Columbia, MO, 65201, US
    38.944491 -92.326012
  • Engineering Library & Technology CommonsBorrow it
    W2001 Lafferre Hall, Columbia, MO, 65211, US
    38.946102 -92.330125
  • Fisher Delta Research CenterBorrow it
    2-64 Agricultural Bldg, Columbia, MO, 65201, US
    38.958397 -92.303491
  • Geological Sciences LibraryBorrow it
    201 Geological Sciences, Columbia, MO, 65211, US
    38.947375 -92.329062
  • J. Otto Lottes Health Sciences LibraryBorrow it
    1 Hospital Dr, Columbia, MO, 65201, US
    38.939544 -92.328377
  • Journalism LibraryBorrow it
    102 Reynolds Jrnlism Institute, Columbia, MO, 65211, US
    38.947290 -92.328025
  • Mathematical Sciences LibraryBorrow it
    104 Ellis Library, Columbia, MO, 65201, US
    38.944377 -92.326537
  • University ArchivesBorrow it
    Columbia, MO, 65201, US
  • University Archives McAlester AnnexBorrow it
    703 Lewis Hall, Columbia, MO, 65211, US
    38.934630 -92.342290
  • University of Missouri Libraries DepositoryBorrow it
    2908 Lemone Blvd, Columbia, MO, 65211, US
    38.919360 -92.291620
  • Zalk Veterinary Medical LibraryBorrow it
    Veterinary Medicine West, Columbia, MO, 65211, US
    38.941099 -92.317911
Processing Feedback ...