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The Resource Complement therapeutics, John D. Lambris, V. Michael Holers, Daniel Ricklin, editors

Complement therapeutics, John D. Lambris, V. Michael Holers, Daniel Ricklin, editors

Contributor
Summary
This book highlights progress and trends in the rapidly evolving field of complement-related drug discovery and spotlights examples of clinical applications. As an integral part of innate immunity and critical mediator in homeostatic and inflammatory processes, the human complement system has been identified as contributor to a large number of disorders including ocular, cardiovascular, metabolic, autoimmune, and inflammatory diseases as well as in ischemia/reperfusion injury, cancer and sepsis. In addition, complement is often involved in adverse immune reactions to biomaterials, cell and organ transplants or drug delivery systems. Although the complement cascade with its close to 50 extracellular protein targets has long been recognized as an attractive system for therapeutic modulation, the past few years have seen a particularly strong boost in interest. Fueled by novel research insight and the marketing of the first complement-targeted drugs, a plethora of highly creative treatment approaches and potent drug candidates have recently emerged and are currently evaluated in disease models and clinical trials. The chapters in this book cover a wide range of topics related to the development of complement therapeutics, ranging from the molecular and functional description of complement targets to the presentation of novel inhibitors, improved treatment strategies as well as examples of disease models and clinical applications. The broad and up-to-date overview on a highly versatile and dynamic field renders this book an indispensable source of information for researchers and clinicians dealing with therapeutic and disease-related aspects of the human complement system
Language
eng
Work
Publication
Extent
1 online resource
Contents
  • DAF as a Therapeutic Target for Steroid Hormones: Implications for Host-Pathogen Interactions
  • Bogdan Nowicki and Stella Nowicki
  • Targeting gC1qR Domains for Therapy Against Infection and Inflammation
  • Berhane Ghebrehiwet, Jolyon Jesty, Rama Vinayagasundaram, Uma Vinayagasundaram and Yan Ji, et al.
  • The Alternative C5a Receptor Function
  • Hiroshi Nishiura
  • The Effects of Selective Complement and CD14 Inhibition on the E. coli-Induced Tissue Factor mRNA Upregulation, Monocyte Tissue Factor Expression, and Tissue Factor Functional Activity in Human Whole Blood
  • O.-L. Brekke, C. Waage, D. Christiansen, H. Fure and H. Qu, et al
  • Progress and Trends in Complement Therapeutics
  • Daniel Ricklin and John D. Lambris
  • Inhibition of the Serine Proteases of the Complement System
  • Péter Gál, József Dobó, László Beinrohr, Gábor Pál and Péter Závodszky
  • The Role of MASP-1/3 in Complement Activation
  • Hideharu Sekine, Minoru Takahashi, Daisuke Iwaki and Teizo Fujita
  • Membrane-Bound Complement Regulatory Proteins as Biomarkers and Potential Therapeutic Targets for SLE
  • Nibhriti Das, Bintili Biswas and Rohan Khera
  • Complement-Targeted Therapeutics in Periodontitis
  • George Hajishengallis and John D. Lambris
  • Complement System Activation in Cardiac and Skeletal Muscle Pathology: Friend or Foe?
  • Maro Syriga and Manolis Mavroidis
  • CR2-Mediated Targeting of Complement Inhibitors: Bench-to-Bedside Using a Novel Strategy for Site-Specific Complement Modulation
  • V. Michael Holers, Bärbel Rohrer and Stephen Tomlinson
  • Paroxysmal Nocturnal Hemoglobinuria and the Complement System: Recent Insights and Novel Anticomplement Strategies
  • Antonio M. Risitano
  • Defective Complement Action and Control Defines Disease Pathology for Retinal and Renal Disorders and Provides a Basis for New Therapeutic Approaches
  • Peter F. Zipfel and Nadine Lauer
  • C3 Glomerulonephritis/CFHR5 Nephropathy Is an Endemic Disease in Cyprus: Clinical and Molecular Findings in 21 Families
  • Constantinos Deltas, Daniel Gale, Terence Cook, Konstantinos Voskarides and Yiannis Athanasiou, et al.
  • Noninvasive Detection of Complement Activation Through Radiologic Imaging
  • Joshua M. Thurman and Bärbel Rohrer
  • Highly Multiplexed Proteomic Platform for Biomarker Discovery, Diagnostics, and Therapeutics
  • Michael R. Mehan, Rachel Ostroff, Sheri K. Wilcox, Fintan Steele and Daniel Schneider, et al.
  • Complement in Action: An Analysis of Patent Trends from 1976 Through 2011
  • Kun Yang, Robert A. DeAngelis, Janet E. Reed, Daniel Ricklin and John D. Lambris
  • Innate Immunity as Orchestrator of Bone Marrow Homing for Hematopoietic Stem/Progenitor Cells
  • Mariusz Z. Ratajczak, ChiHwa Kim, Janina Ratajczak and Anna Janowska-Wieczorek
  • Complement-Mediated Microvascular Injury Leads to Chronic Rejection
  • Mohammad A. Khan and Mark R. Nicolls
  • Targeting Complement at the Time of Transplantation
  • Steven Sacks, Julia Karegli, Conrad A. Farrar, Elham Asgari and Wilhelm Schwaeble, et al.
  • Evaluation of the Blood Compatibility of Materials, Cells, and Tissues: Basic Concepts, Test Models, and Practical Guidelines
  • Kristina N. Ekdahl, Jaan Hong, Osama A. Hamad, Rolf Larsson and Bo Nilsson
  • Summary and conclusion
  • Part 2.
  • Introduction
  • Biomedical diamagnetic spin and electric-qudrupole interaction systems
  • Practical illustrations sodium spectroscopy and imaging: clinical applications
  • Summary and discussion
  • Conclusion and future horizons
  • Part 1.
  • Introduction
  • Simplistic theory of the functions of the ensemble of the electrons, atoms, molecules, nuclei, in the brain
  • Practical illustrations
  • Quantum spin dynamics and the MRI
  • The density matrix concept
  • The imaging
  • Future horizons of the brain science
Isbn
9781461441182
Instance
Label
Complement therapeutics
Title
Complement therapeutics
Statement of responsibility
John D. Lambris, V. Michael Holers, Daniel Ricklin, editors
Contributor
Subject
Language
eng
Summary
This book highlights progress and trends in the rapidly evolving field of complement-related drug discovery and spotlights examples of clinical applications. As an integral part of innate immunity and critical mediator in homeostatic and inflammatory processes, the human complement system has been identified as contributor to a large number of disorders including ocular, cardiovascular, metabolic, autoimmune, and inflammatory diseases as well as in ischemia/reperfusion injury, cancer and sepsis. In addition, complement is often involved in adverse immune reactions to biomaterials, cell and organ transplants or drug delivery systems. Although the complement cascade with its close to 50 extracellular protein targets has long been recognized as an attractive system for therapeutic modulation, the past few years have seen a particularly strong boost in interest. Fueled by novel research insight and the marketing of the first complement-targeted drugs, a plethora of highly creative treatment approaches and potent drug candidates have recently emerged and are currently evaluated in disease models and clinical trials. The chapters in this book cover a wide range of topics related to the development of complement therapeutics, ranging from the molecular and functional description of complement targets to the presentation of novel inhibitors, improved treatment strategies as well as examples of disease models and clinical applications. The broad and up-to-date overview on a highly versatile and dynamic field renders this book an indispensable source of information for researchers and clinicians dealing with therapeutic and disease-related aspects of the human complement system
Member of
Cataloging source
GW5XE
Dewey number
615.7
Index
index present
LC call number
RM301.63
LC item number
.C66 2013
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
QV 785
http://library.link/vocab/relatedWorkOrContributorDate
1952-
http://library.link/vocab/relatedWorkOrContributorName
  • Lambris, J. D.
  • Holers, V. Michael
  • Ricklin, Daniel
Series statement
Advances in experimental medicine and biology,
Series volume
v. 735
http://library.link/vocab/subjectName
  • Drug targeting
  • Drug development
  • Complement Activation
  • Complement System Proteins
  • Complement Activation
  • Complement Inactivating Agents
  • Complement Inactivator Proteins
  • Drug Discovery
  • Immunoproteins
  • Immunosuppressive Agents
  • Biological Science Disciplines
  • Immune System Phenomena
  • Receptors, Immunologic
  • Drug Therapy
  • Therapeutics
  • Blood Proteins
  • Immunologic Factors
  • Chemistry, Pharmaceutical
  • Receptors, Cell Surface
  • Natural Science Disciplines
  • Investigative Techniques
  • Disciplines and Occupations
  • Physiological Effects of Drugs
  • Analytical, Diagnostic and Therapeutic Techniques and Equipment
  • Chemistry
  • Phenomena and Processes
  • Membrane Proteins
  • Proteins
  • Pharmacologic Actions
  • Amino Acids, Peptides, and Proteins
  • Chemical Actions and Uses
  • Chemicals and Drugs
  • Complement System Proteins
  • Drug Design
  • Complement Inactivating Agents
  • Pharmacology
  • Complement Inactivator Proteins
  • Complement Activation
  • Receptors, Complement
  • Drug Delivery Systems
  • MEDICAL
  • Drug development
  • Drug targeting
Label
Complement therapeutics, John D. Lambris, V. Michael Holers, Daniel Ricklin, editors
Instantiates
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • DAF as a Therapeutic Target for Steroid Hormones: Implications for Host-Pathogen Interactions
  • Bogdan Nowicki and Stella Nowicki
  • Targeting gC1qR Domains for Therapy Against Infection and Inflammation
  • Berhane Ghebrehiwet, Jolyon Jesty, Rama Vinayagasundaram, Uma Vinayagasundaram and Yan Ji, et al.
  • The Alternative C5a Receptor Function
  • Hiroshi Nishiura
  • The Effects of Selective Complement and CD14 Inhibition on the E. coli-Induced Tissue Factor mRNA Upregulation, Monocyte Tissue Factor Expression, and Tissue Factor Functional Activity in Human Whole Blood
  • O.-L. Brekke, C. Waage, D. Christiansen, H. Fure and H. Qu, et al
  • Progress and Trends in Complement Therapeutics
  • Daniel Ricklin and John D. Lambris
  • Inhibition of the Serine Proteases of the Complement System
  • Péter Gál, József Dobó, László Beinrohr, Gábor Pál and Péter Závodszky
  • The Role of MASP-1/3 in Complement Activation
  • Hideharu Sekine, Minoru Takahashi, Daisuke Iwaki and Teizo Fujita
  • Membrane-Bound Complement Regulatory Proteins as Biomarkers and Potential Therapeutic Targets for SLE
  • Nibhriti Das, Bintili Biswas and Rohan Khera
  • Complement-Targeted Therapeutics in Periodontitis
  • George Hajishengallis and John D. Lambris
  • Complement System Activation in Cardiac and Skeletal Muscle Pathology: Friend or Foe?
  • Maro Syriga and Manolis Mavroidis
  • CR2-Mediated Targeting of Complement Inhibitors: Bench-to-Bedside Using a Novel Strategy for Site-Specific Complement Modulation
  • V. Michael Holers, Bärbel Rohrer and Stephen Tomlinson
  • Paroxysmal Nocturnal Hemoglobinuria and the Complement System: Recent Insights and Novel Anticomplement Strategies
  • Antonio M. Risitano
  • Defective Complement Action and Control Defines Disease Pathology for Retinal and Renal Disorders and Provides a Basis for New Therapeutic Approaches
  • Peter F. Zipfel and Nadine Lauer
  • C3 Glomerulonephritis/CFHR5 Nephropathy Is an Endemic Disease in Cyprus: Clinical and Molecular Findings in 21 Families
  • Constantinos Deltas, Daniel Gale, Terence Cook, Konstantinos Voskarides and Yiannis Athanasiou, et al.
  • Noninvasive Detection of Complement Activation Through Radiologic Imaging
  • Joshua M. Thurman and Bärbel Rohrer
  • Highly Multiplexed Proteomic Platform for Biomarker Discovery, Diagnostics, and Therapeutics
  • Michael R. Mehan, Rachel Ostroff, Sheri K. Wilcox, Fintan Steele and Daniel Schneider, et al.
  • Complement in Action: An Analysis of Patent Trends from 1976 Through 2011
  • Kun Yang, Robert A. DeAngelis, Janet E. Reed, Daniel Ricklin and John D. Lambris
  • Innate Immunity as Orchestrator of Bone Marrow Homing for Hematopoietic Stem/Progenitor Cells
  • Mariusz Z. Ratajczak, ChiHwa Kim, Janina Ratajczak and Anna Janowska-Wieczorek
  • Complement-Mediated Microvascular Injury Leads to Chronic Rejection
  • Mohammad A. Khan and Mark R. Nicolls
  • Targeting Complement at the Time of Transplantation
  • Steven Sacks, Julia Karegli, Conrad A. Farrar, Elham Asgari and Wilhelm Schwaeble, et al.
  • Evaluation of the Blood Compatibility of Materials, Cells, and Tissues: Basic Concepts, Test Models, and Practical Guidelines
  • Kristina N. Ekdahl, Jaan Hong, Osama A. Hamad, Rolf Larsson and Bo Nilsson
  • Summary and conclusion
  • Part 2.
  • Introduction
  • Biomedical diamagnetic spin and electric-qudrupole interaction systems
  • Practical illustrations sodium spectroscopy and imaging: clinical applications
  • Summary and discussion
  • Conclusion and future horizons
  • Part 1.
  • Introduction
  • Simplistic theory of the functions of the ensemble of the electrons, atoms, molecules, nuclei, in the brain
  • Practical illustrations
  • Quantum spin dynamics and the MRI
  • The density matrix concept
  • The imaging
  • Future horizons of the brain science
Control code
811619688
Dimensions
unknown
Extent
1 online resource
File format
unknown
Form of item
online
Isbn
9781461441182
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-1-4614-4118-2
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)811619688
Label
Complement therapeutics, John D. Lambris, V. Michael Holers, Daniel Ricklin, editors
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • DAF as a Therapeutic Target for Steroid Hormones: Implications for Host-Pathogen Interactions
  • Bogdan Nowicki and Stella Nowicki
  • Targeting gC1qR Domains for Therapy Against Infection and Inflammation
  • Berhane Ghebrehiwet, Jolyon Jesty, Rama Vinayagasundaram, Uma Vinayagasundaram and Yan Ji, et al.
  • The Alternative C5a Receptor Function
  • Hiroshi Nishiura
  • The Effects of Selective Complement and CD14 Inhibition on the E. coli-Induced Tissue Factor mRNA Upregulation, Monocyte Tissue Factor Expression, and Tissue Factor Functional Activity in Human Whole Blood
  • O.-L. Brekke, C. Waage, D. Christiansen, H. Fure and H. Qu, et al
  • Progress and Trends in Complement Therapeutics
  • Daniel Ricklin and John D. Lambris
  • Inhibition of the Serine Proteases of the Complement System
  • Péter Gál, József Dobó, László Beinrohr, Gábor Pál and Péter Závodszky
  • The Role of MASP-1/3 in Complement Activation
  • Hideharu Sekine, Minoru Takahashi, Daisuke Iwaki and Teizo Fujita
  • Membrane-Bound Complement Regulatory Proteins as Biomarkers and Potential Therapeutic Targets for SLE
  • Nibhriti Das, Bintili Biswas and Rohan Khera
  • Complement-Targeted Therapeutics in Periodontitis
  • George Hajishengallis and John D. Lambris
  • Complement System Activation in Cardiac and Skeletal Muscle Pathology: Friend or Foe?
  • Maro Syriga and Manolis Mavroidis
  • CR2-Mediated Targeting of Complement Inhibitors: Bench-to-Bedside Using a Novel Strategy for Site-Specific Complement Modulation
  • V. Michael Holers, Bärbel Rohrer and Stephen Tomlinson
  • Paroxysmal Nocturnal Hemoglobinuria and the Complement System: Recent Insights and Novel Anticomplement Strategies
  • Antonio M. Risitano
  • Defective Complement Action and Control Defines Disease Pathology for Retinal and Renal Disorders and Provides a Basis for New Therapeutic Approaches
  • Peter F. Zipfel and Nadine Lauer
  • C3 Glomerulonephritis/CFHR5 Nephropathy Is an Endemic Disease in Cyprus: Clinical and Molecular Findings in 21 Families
  • Constantinos Deltas, Daniel Gale, Terence Cook, Konstantinos Voskarides and Yiannis Athanasiou, et al.
  • Noninvasive Detection of Complement Activation Through Radiologic Imaging
  • Joshua M. Thurman and Bärbel Rohrer
  • Highly Multiplexed Proteomic Platform for Biomarker Discovery, Diagnostics, and Therapeutics
  • Michael R. Mehan, Rachel Ostroff, Sheri K. Wilcox, Fintan Steele and Daniel Schneider, et al.
  • Complement in Action: An Analysis of Patent Trends from 1976 Through 2011
  • Kun Yang, Robert A. DeAngelis, Janet E. Reed, Daniel Ricklin and John D. Lambris
  • Innate Immunity as Orchestrator of Bone Marrow Homing for Hematopoietic Stem/Progenitor Cells
  • Mariusz Z. Ratajczak, ChiHwa Kim, Janina Ratajczak and Anna Janowska-Wieczorek
  • Complement-Mediated Microvascular Injury Leads to Chronic Rejection
  • Mohammad A. Khan and Mark R. Nicolls
  • Targeting Complement at the Time of Transplantation
  • Steven Sacks, Julia Karegli, Conrad A. Farrar, Elham Asgari and Wilhelm Schwaeble, et al.
  • Evaluation of the Blood Compatibility of Materials, Cells, and Tissues: Basic Concepts, Test Models, and Practical Guidelines
  • Kristina N. Ekdahl, Jaan Hong, Osama A. Hamad, Rolf Larsson and Bo Nilsson
  • Summary and conclusion
  • Part 2.
  • Introduction
  • Biomedical diamagnetic spin and electric-qudrupole interaction systems
  • Practical illustrations sodium spectroscopy and imaging: clinical applications
  • Summary and discussion
  • Conclusion and future horizons
  • Part 1.
  • Introduction
  • Simplistic theory of the functions of the ensemble of the electrons, atoms, molecules, nuclei, in the brain
  • Practical illustrations
  • Quantum spin dynamics and the MRI
  • The density matrix concept
  • The imaging
  • Future horizons of the brain science
Control code
811619688
Dimensions
unknown
Extent
1 online resource
File format
unknown
Form of item
online
Isbn
9781461441182
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-1-4614-4118-2
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)811619688

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