The Resource Definition of VPU sensitivity using a model VPU target and role of hydrophobicity of the membrane spanning domain in the viral envelope glycoprotein fusogenicity, by Sanath Kumar Janaka

Definition of VPU sensitivity using a model VPU target and role of hydrophobicity of the membrane spanning domain in the viral envelope glycoprotein fusogenicity, by Sanath Kumar Janaka

Label
Definition of VPU sensitivity using a model VPU target and role of hydrophobicity of the membrane spanning domain in the viral envelope glycoprotein fusogenicity
Title
Definition of VPU sensitivity using a model VPU target and role of hydrophobicity of the membrane spanning domain in the viral envelope glycoprotein fusogenicity
Statement of responsibility
by Sanath Kumar Janaka
Creator
Contributor
Author
Thesis advisor
Subject
Genre
Language
eng
Summary
Retroviral compatibility with diverse glycoproteins has been known and identified through the course of several studies. However, molecular mechanisms of glycoprotein acquisition are poorly defined. Glycoproteins are acquired by the virus as it buds out of the cell at the plasma membrane. Budding of retroviruses involves multiple interactions between viral and cellular proteins and a mature viral particle is the consummation of a regulated and a sequential process. Currently there are no drugs to target the assembly step of retrovirus. In the series of studies outlined here, we outline a physical factor, Vpu that contributes to glycoprotein exclusion from HIV particles. Using a model Vpu target, Gibbon ape Leukemia Virus (GaLV) Env, we have deduced the characteristics of a protein that is targeted by Vpu through its cytoplasmic tail domain (CTD). This unique observation of Vpu modulating the GaLV Env CTD allowed us to compare the two modes of Vpu mediated protein modulation- CTD mediated and membrane spanning domain (MSD) mediated. Subsequently, we studied the contribution of MSD hydrophobicity to Env recruitment to viral budding sites. Curiously, although hydrophobicity of MSD did not dictate Env recruitment, the helicity changes as a result of our mutations resulted in observation of the Env fusogenicity
Cataloging source
MUU
http://library.link/vocab/creatorDate
1986-
http://library.link/vocab/creatorName
Janaka, Sanath Kumar
Degree
Ph.D.
Dissertation note
Dissertation
Dissertation year
2013.
Government publication
government publication of a state province territory dependency etc
Granting institution
University of Missouri--Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
Johnson, Marc
http://library.link/vocab/subjectName
  • HIV (Viruses)
  • HIV (Viruses)
  • Glycoproteins
  • Retroviruses
Label
Definition of VPU sensitivity using a model VPU target and role of hydrophobicity of the membrane spanning domain in the viral envelope glycoprotein fusogenicity, by Sanath Kumar Janaka
Instantiates
Publication
Note
  • "May 2013."
  • "A Dissertation presented to the Faculty of the Graduate School at the University of Missouri--Columbia In Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy."
  • Dissertation supervisor: Dr. Marc Johnson
  • Vita
Bibliography note
Includes bibliographical references (pages 174-201)
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
txt
Content type MARC source
rdacontent.
Control code
891140988
Extent
1 online resource (x, 202 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
c
Other physical details
illustrations (some color)
Specific material designation
remote
System control number
(OCoLC)891140988
Label
Definition of VPU sensitivity using a model VPU target and role of hydrophobicity of the membrane spanning domain in the viral envelope glycoprotein fusogenicity, by Sanath Kumar Janaka
Publication
Note
  • "May 2013."
  • "A Dissertation presented to the Faculty of the Graduate School at the University of Missouri--Columbia In Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy."
  • Dissertation supervisor: Dr. Marc Johnson
  • Vita
Bibliography note
Includes bibliographical references (pages 174-201)
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
txt
Content type MARC source
rdacontent.
Control code
891140988
Extent
1 online resource (x, 202 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
c
Other physical details
illustrations (some color)
Specific material designation
remote
System control number
(OCoLC)891140988

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