The Resource Deregulation of the notch signaling pathway N B-cell chronic lymphocytic leukemia, by Charu Kaiwar, (electronic resource)

Deregulation of the notch signaling pathway N B-cell chronic lymphocytic leukemia, by Charu Kaiwar, (electronic resource)

Label
Deregulation of the notch signaling pathway N B-cell chronic lymphocytic leukemia
Title
Deregulation of the notch signaling pathway N B-cell chronic lymphocytic leukemia
Statement of responsibility
by Charu Kaiwar
Creator
Subject
Genre
Language
eng
Summary
B-cell Chronic Lymphocytic Leukemia (B-CLL) is the most common hematological malignancy in United States [1], characterized by CD5+ B-lymphocytes in peripheral blood. Deregulation of the Notch signaling pathway has been suggested to contribute to B-CLL pathogenesis [2-4]. Our objective was to characterize the differential expression of the Notch pathway genes in B-CLL cell lines as compared to normal B-cells and to determine if inhibiting the Notch pathway using [gamma]-secretase inhibitors (GSIs would lead to increased death in B-CLL cells. We observed over-expression of Notch pathway genes in three B-CLL cell lines. Treatment with either of the GSIs, DAPT(N-[N-(3, 5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl Ester) or Compound E, failed to have any effect on proliferation or death of these cells. Moreover, there was no alteration in transcription of downstream Notch target genes Hairy and enhancer of split 1, (HES1) Hairy/enhancer-of-split related with YRPW motif 1( HEY1), or Deltex homolog 1 (DTX1) in treated vs. untreated cells. These findings suggest that although Notch pathway genes seem to up regulated in B-B-CLL, inhibition of the pathway does not lead to cell death nor does it alter Notch target gene transcripton. One explanation could be that the Notch receptor is constitutively active in B-CLL as in other hematological malignancies like Tcell-Acute Lymphoblastic Leukemia (T-ALL) [5]. Alternatively, the survival of leukemic cells in B-CLL as well as transcription of the target genes examined, may be a combined result of signaling via the Notch and other signaling pathways such as Jak-STAT, Wnt and Sonic hedgehog, which have roles in B-CLL pathogenesis [6-10]
Cataloging source
MMU
http://library.link/vocab/creatorName
Kaiwar, Charu
Degree
M.S.
Dissertation year
2011.
Government publication
government publication of a state province territory dependency etc
Granting institution
University of Missouri--Columbia,
Illustrations
illustrations
Index
no index present
LC call number
RC280.L9
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
NLM call number
QZ 350
http://library.link/vocab/subjectName
  • Chronic lymphocytic leukemia
  • Notch proteins
  • Cellular signal transduction
  • Endopeptidases
  • Cell death
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Receptors, Notch
  • Amyloid Precursor Protein Secretases
  • Cell Death
  • Signal Transduction
Label
Deregulation of the notch signaling pathway N B-cell chronic lymphocytic leukemia, by Charu Kaiwar, (electronic resource)
Instantiates
Publication
Contributor
Thesis advisor
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Thesis advisors: Charles W. Caldwell M.D., PhD and Lynda B. Bennett PhD
  • "May 2011"
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
809702821
Extent
1 online resource (v, 22 pages
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
MU-HSL: Access is limited to the University of Missouri - Columbia campus.
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)809702821
Label
Deregulation of the notch signaling pathway N B-cell chronic lymphocytic leukemia, by Charu Kaiwar, (electronic resource)
Publication
Contributor
Thesis advisor
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Thesis advisors: Charles W. Caldwell M.D., PhD and Lynda B. Bennett PhD
  • "May 2011"
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
809702821
Extent
1 online resource (v, 22 pages
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
MU-HSL: Access is limited to the University of Missouri - Columbia campus.
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)809702821

Library Locations

    • Ellis LibraryBorrow it
      1020 Lowry Street, Columbia, MO, 65201, US
      38.944491 -92.326012
    • J. Otto Lottes Health Sciences LibraryBorrow it
      1 Hospital Dr, Columbia, MO, 65201, US
      38.939544 -92.328377
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