The Resource Development and applications of label-free optofluidic ring resonator biosensor, by Hongying Zhu, (electronic resource)

Development and applications of label-free optofluidic ring resonator biosensor, by Hongying Zhu, (electronic resource)

Label
Development and applications of label-free optofluidic ring resonator biosensor
Title
Development and applications of label-free optofluidic ring resonator biosensor
Statement of responsibility
by Hongying Zhu
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
This dissertation presents the development and applications of label-free optofluidic ring resonator (OFRR) sensor platform. The OFRR sensor naturally integrates the optical ring resonator with the capillary microfluidics by employing a micro-sized glass capillary with a thin wall. Each capillary cross section forms an optical ring resonator to support the circulating optical resonance called whispering gallery modes (WGMs) via total internal reflection (TIR). The OFRR sensor utilizes the resonance wavelength shift in response to the surrounding refractive index change as the transduction signal to monitor the biomolecular interaction on the sensor surface. The OFRR sensing principle, fabrication methods, and experimental setup design are introduced in detail. Based on the OFRR sensor platform, four different investigations are performed to demonstrate the OFRR label-free biosensing capability. A theory is developed to analyze the OFRR surface sensing sensitivity and to estimate the biomolecule surface density. Experiments are performed to demonstrate the non-specific protein binding detection, specific protein binding detection, and specific virus detection in the PBS buffer with the OFRR sensor, which characterize the OFRR sensor biosensing performance. Further study utilizes the OFRR sensor to quantify the breast cancer biomarker in clinical human serum, which marks the first application of the optical ring resonator sensor for real clinical applications
Cataloging source
MUU
http://library.link/vocab/creatorDate
1982-
http://library.link/vocab/creatorName
Zhu, Hongying
Degree
Ph. D.
Dissertation year
2009.
Granting institution
University of Missouri--Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
Fan, Xudong
http://library.link/vocab/subjectName
  • Optofluidics
  • Optical resonance
  • Total internal reflection (Optics)
  • Biosensors
  • Breast
Target audience
specialized
Label
Development and applications of label-free optofluidic ring resonator biosensor, by Hongying Zhu, (electronic resource)
Instantiates
Publication
Note
  • The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file
  • Title from PDF of title page (University of Missouri--Columbia, viewed on January 28, 2011)
  • Thesis advisor: Dr. Xudong Fan
  • Vita
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
698784853
Extent
1 online resource (xviii, 143 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
c
Note
MU: Access is limited to the campuses of the University of Missouri.
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)698784853
Label
Development and applications of label-free optofluidic ring resonator biosensor, by Hongying Zhu, (electronic resource)
Publication
Note
  • The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file
  • Title from PDF of title page (University of Missouri--Columbia, viewed on January 28, 2011)
  • Thesis advisor: Dr. Xudong Fan
  • Vita
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
698784853
Extent
1 online resource (xviii, 143 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
c
Note
MU: Access is limited to the campuses of the University of Missouri.
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)698784853

Library Locations

    • Ellis LibraryBorrow it
      1020 Lowry Street, Columbia, MO, 65201, US
      38.944491 -92.326012
    • Engineering Library & Technology CommonsBorrow it
      W2001 Lafferre Hall, Columbia, MO, 65211, US
      38.946102 -92.330125
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