Coverart for item
The Resource Development and characterization of gold nanoparticle-collagen scaffold, by Jiaxun Zhu

Development and characterization of gold nanoparticle-collagen scaffold, by Jiaxun Zhu

Label
Development and characterization of gold nanoparticle-collagen scaffold
Title
Development and characterization of gold nanoparticle-collagen scaffold
Statement of responsibility
by Jiaxun Zhu
Creator
Contributor
Author
Thesis advisor
Subject
Genre
Language
eng
Summary
Collagen is considered a versatile biological material for soft tissue application, owing to its excellent biocompatibility. However in its purified state, collagen is mechanically weak and undergoes rapid degradation. To mitigate these effects, collagen can be cross-linked. While enhanced mechanical properties and stability can be achieved by crosslinking, collagen can be rendered less biocompatible due to changes in the overall microstructure and/or the cytotoxicity of the cross linkers. In this study, we investigated if gold nanoparticles (AuNPs) conjugated Type I porcine collagen to enhanced stability while maintaining the natural microstructure of collagen. The scaffold was characterized using differential scanning calorimetry (DSC) for heat of fusion and denaturation temperature of AuNP-collagen scaffold. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were utilized to determine the microstructure and chemical properties of the scaffold. Neutron activation analysis (NAA) was performed to evaluate the AuNPs crosslinking efficiency and reproducibility of the scaffold. Low concentration peractic acid short-time washing was proved to be an effective sterilization technique without damaging any chemical and mechanical properties of the scaffold. In vitro biocompatibility study was assessed using WST-1 and picogreen dsDNA assays. In vivo biocompatibility was evaluated using Sprague-Dawley rats and White New Zealand rabbits models. Histology study was conducted to obtain irritation scores
Cataloging source
MUU
http://library.link/vocab/creatorName
Zhu, Jiaxun
Degree
M.S.
Dissertation note
Thesis
Dissertation year
2013.
Government publication
government publication of a state province territory dependency etc
Granting institution
University of Missouri--Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
Grant, Sheila Ann
Label
Development and characterization of gold nanoparticle-collagen scaffold, by Jiaxun Zhu
Instantiates
Publication
Note
  • "December 2013."
  • "A Thesis presented to the Faculty of the Graduate School at the University of Missouri--Columbia In Partial Fulfillment of the Requirements for the Degree Master of Science."
  • Thesis supervisor: Dr. Sheila Grant
Bibliography note
Includes bibliographical references (pages 85-88)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent.
Control code
900167400
Extent
1 online resource (xii, 88 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
  • c
Other physical details
illustrations (some color)
Specific material designation
remote
System control number
(OCoLC)900167400
Label
Development and characterization of gold nanoparticle-collagen scaffold, by Jiaxun Zhu
Publication
Note
  • "December 2013."
  • "A Thesis presented to the Faculty of the Graduate School at the University of Missouri--Columbia In Partial Fulfillment of the Requirements for the Degree Master of Science."
  • Thesis supervisor: Dr. Sheila Grant
Bibliography note
Includes bibliographical references (pages 85-88)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent.
Control code
900167400
Extent
1 online resource (xii, 88 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
  • c
Other physical details
illustrations (some color)
Specific material designation
remote
System control number
(OCoLC)900167400

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