The Resource Development of a fluorescence-based protease biosensor using nanoscale platforms, by Craig Ryan Weilbaecher, (electronic resource)

Development of a fluorescence-based protease biosensor using nanoscale platforms, by Craig Ryan Weilbaecher, (electronic resource)

Label
Development of a fluorescence-based protease biosensor using nanoscale platforms
Title
Development of a fluorescence-based protease biosensor using nanoscale platforms
Statement of responsibility
by Craig Ryan Weilbaecher
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
The development of a protease biosensor utilizing nanomaterials is presented in this dissertation. Peptide substrates and nanomaterial platforms were investigated to increase the sensitivity and response time for the detection of protease analytes. Nano-sized platforms, including nanoparticles and nanofibers, offer the advantage of a higher surface area-to-volume ratio contributing to increased immobilization points and a capability of an enhance signal output. Nanoparticles (Silica Nanoparticles, Quantum Dots, and Gold Nanoparticles) in solution and solid surface (Polymer) nanofibers were tested with immobilized peptide substrates that contained fluorophores to acquire fluorescence for signal transduction. A full characterization was accomplished through a variety of optical characterization techniques and an optimized protocol has been developed for each of the sensing systems. The results from these studies are reported for each of the sensing platforms with response to protease analytes
Cataloging source
MUU
http://library.link/vocab/creatorDate
1981-
http://library.link/vocab/creatorName
Weilbaecher, Craig Ryan
Degree
Ph. D.
Dissertation year
2010.
Granting institution
University of Missouri--Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
  • Grant, Sheila Ann
  • Gangopadhyay, Shubhra
http://library.link/vocab/subjectName
  • Proteolytic enzymes
  • Peptides
  • Biosensors
  • Nanoparticles
Target audience
specialized
Label
Development of a fluorescence-based protease biosensor using nanoscale platforms, by Craig Ryan Weilbaecher, (electronic resource)
Instantiates
Publication
Note
  • The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract, appears in the public.pdf file
  • Title from PDF of title page (University of Missouri--Columbia, viewed on May 23, 2011)
  • Thesis advisors: Dr. Sheila A. Grant, Dr. Shubhra Gangopadhyay
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
727405540
Extent
1 online resource (x, 127 pages .)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)727405540
Label
Development of a fluorescence-based protease biosensor using nanoscale platforms, by Craig Ryan Weilbaecher, (electronic resource)
Publication
Note
  • The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract, appears in the public.pdf file
  • Title from PDF of title page (University of Missouri--Columbia, viewed on May 23, 2011)
  • Thesis advisors: Dr. Sheila A. Grant, Dr. Shubhra Gangopadhyay
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
727405540
Extent
1 online resource (x, 127 pages .)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)727405540

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