The Resource Development of a fluorescence resonance energy transfer optical nanoscale biosensor based on a liquid-core waveguide platform, by R. Cody Stringer, (electronic resource)

Development of a fluorescence resonance energy transfer optical nanoscale biosensor based on a liquid-core waveguide platform, by R. Cody Stringer, (electronic resource)

Label
Development of a fluorescence resonance energy transfer optical nanoscale biosensor based on a liquid-core waveguide platform
Title
Development of a fluorescence resonance energy transfer optical nanoscale biosensor based on a liquid-core waveguide platform
Statement of responsibility
by R. Cody Stringer
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
In order to produce a more versatile, adaptable, and effective method for detection of biological analytes, a self-contained and robust fluorescent optical biosensor architecture utilizing fluorescence resonance energy transfer (FRET) is proposed. This biosensor architecture is then applied to a highly adept liquid-core waveguide platform. FRET is a distance-dependent signal transduction method that occurs between two fluorescent molecules, termed the donor and acceptor. When the donor and acceptor are brought within close proximity, a quantifiable nonradiative energy exchange takes place. In order to launch FRET, a donor-labeled Protein A molecule is bound to an acceptor-labeled capture antibody. When exposed to antigen, the antibody-antigen binding event initiates a conformational change within the structure of the antibody, and thereby induces a measurable change in energy transfer from the donor to the acceptor by altering the distance between the FRET pair. Additionally, effects of quantum dots and gold nanoparticles utilized within the FRET system are studied. The resulting system is then optimized and tested in a liquid-core waveguide platform that is able to retrieve sensitive and accurate measurements. In the current study, the biosensor was used to detect Porcine Reproductive and Respiratory Syndrome virus and human cardiac Troponin I, showing ample sensitivity and a high degree of specificity, as well as rapid response
Cataloging source
MUU
http://library.link/vocab/creatorDate
1983-
http://library.link/vocab/creatorName
Stringer, R. Cody
Degree
M.S.
Dissertation year
2007.
Granting institution
University of Missouri-Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
Grant, Sheila Ann
http://library.link/vocab/subjectName
  • Biosensors
  • Fluorescent probes
  • Energy transfer
  • Wave guides
Target audience
specialized
Label
Development of a fluorescence resonance energy transfer optical nanoscale biosensor based on a liquid-core waveguide platform, by R. Cody Stringer, (electronic resource)
Instantiates
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from title screen of research.pdf file (viewed on September 30, 2008)
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
mixed
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
259283428
Dimensions
unknown
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
c
Specific material designation
remote
System control number
(OCoLC)259283428
System details
Mode of access: World Wide Web
Label
Development of a fluorescence resonance energy transfer optical nanoscale biosensor based on a liquid-core waveguide platform, by R. Cody Stringer, (electronic resource)
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from title screen of research.pdf file (viewed on September 30, 2008)
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
mixed
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
259283428
Dimensions
unknown
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
c
Specific material designation
remote
System control number
(OCoLC)259283428
System details
Mode of access: World Wide Web

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