Coverart for item
The Resource Drug-DNA interaction protocols, edited by Keith R. Fox

Drug-DNA interaction protocols, edited by Keith R. Fox

Label
Drug-DNA interaction protocols
Title
Drug-DNA interaction protocols
Statement of responsibility
edited by Keith R. Fox
Contributor
Subject
Language
eng
Summary
In Drug-DNA Interactions, expert researchers describe powerful molecular techniques designed to illuminate and explore the interaction of drugs and ligands with DNA, often perfected in their own laboratories, . These easily reproducible methods involve sequence recognition properties, as well as physical approaches to measuring both the strength of interaction and the mode of drug binding to DNA. Drug interactions are also examined from a cellular perspective and for their usefulness in the development of new therapeutic agents. Drug-DNA Interactions will be highly useful to all investigators needing the kind of detailed experimental and technical information often omitted from scientific papers. Those wishing to expand their repertoire of experimental techniques or to improve their current techniques will also find these powerful methods particularly helpful in elucidating the action of existing therapeutic agents, as well as in designing new anticancer drugs with improved action and reduced toxicity
Member of
Action
digitized
Cataloging source
YNG
Dewey number
615/.7045
Illustrations
illustrations
Index
index present
Language note
English
LC call number
QP624.75.D77
LC item number
D78 1997
Literary form
non fiction
NAL call number
QH506.M45
NAL item number
no.90
Nature of contents
  • dictionaries
  • bibliography
NLM call number
  • W1
  • QU 58.5
NLM item number
  • ME9616J v.90 1997
  • D794 1997
http://library.link/vocab/relatedWorkOrContributorName
Fox, Keith R
Series statement
Methods in molecular biology
Series volume
v. 90
http://library.link/vocab/subjectName
  • DNA-drug interactions
  • DNA
  • DNA Footprinting
  • DNA Probes
  • DNA-Binding Proteins
  • Polymerase Chain Reaction
  • DNA-drug interactions
  • Geneesmiddelen
  • DNA
  • Wetenschappelijke technieken
Target audience
adult
Label
Drug-DNA interaction protocols, edited by Keith R. Fox
Instantiates
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
DNase I footprinting / Keith R. Fox -- Quantitative DNA footprinting / James C. Dabrowiak, Jerry Goodisman, Brian Ward -- Uranyl photoprobing of DNA Structures and drug-DNA complexes / Niels Erik Møllegaard, Peter E. Nielsen -- Diethylpyrocarbonate and osmium tetroxide as probes for drug-induced changes in DNA conformation in vitro / Christian Bailly, Michael J. Waring -- Footprinting studies with nucleosome-bound DNA / Philip M. Brown, Keith R. Fox -- A gel mobility shift assay for probing the effect of drug-DNA adducts on DNA-binding proteins / Suzanne M. Cutts, Andrew Masta, Con Panousis, Peter G. Parsons, Richard A. Sturm, Don R. Phillips -- An oligonucleotide crosslinking assay for the analysis of individual drug-binding sites / Suzanne M. Cutts, Con Panousis, Andrew Masta, Don R. Phillips -- DNA polymerase inhibition assay (PIA) for the detection of drug-DNA interactions / Thomas P. Dooley, Katherine L. Weiland -- Transcriptional footprinting of drug-DNA interactions / Don R. Phillips, Carleen Cullinane -- Determination of the DNA sequence specificity of alkylation damage using cleavage-based assays / John A. Hartley, Michael D. Wyatt -- PCR-based methods for detecting DNA damage and its repair at the subgene and single nucleotide levels in cells / Keith A. Grimaldi, John A. Hartley -- Analysis of DNA-binding antibodies / Jeremy S. Lee, Laura J. Latimer, Jamshid Tanha -- Immunofluorescent staining of chromosomes with DNA-binding antibodies / Jeremy S. Lee, Laura J. Latimer, Gary D. Burkholder -- Optical absorbance and fluorescence techniques for measuring DNA-drug interactions / Terence C. Jenkins -- Evaluation of drug-nucleic acid interactions by thermal melting curves / W. David Wilson, Farial A. Tanious, Maria Fernandez-Saiz, C. Ted Rigl -- Electric dichroism / Dietmar Porschke -- Calorimetric techniques for studying drug-DNA interactions / Harry P. Hopkins -- Methods for the studies of drug dissociation from DNA / Fu-Ming Chen
Control code
230743523
Dimensions
unknown
Extent
1 online resource (x, 278 pages)
File format
one file format
Form of item
online
Isbn
9781592595747
Lccn
97217431
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1385/089603447X.
Other physical details
illustrations.
Quality assurance targets
unknown
Reproduction note
Electronic reproduction.
Specific material designation
remote
System control number
(OCoLC)230743523
System details
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
Label
Drug-DNA interaction protocols, edited by Keith R. Fox
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
DNase I footprinting / Keith R. Fox -- Quantitative DNA footprinting / James C. Dabrowiak, Jerry Goodisman, Brian Ward -- Uranyl photoprobing of DNA Structures and drug-DNA complexes / Niels Erik Møllegaard, Peter E. Nielsen -- Diethylpyrocarbonate and osmium tetroxide as probes for drug-induced changes in DNA conformation in vitro / Christian Bailly, Michael J. Waring -- Footprinting studies with nucleosome-bound DNA / Philip M. Brown, Keith R. Fox -- A gel mobility shift assay for probing the effect of drug-DNA adducts on DNA-binding proteins / Suzanne M. Cutts, Andrew Masta, Con Panousis, Peter G. Parsons, Richard A. Sturm, Don R. Phillips -- An oligonucleotide crosslinking assay for the analysis of individual drug-binding sites / Suzanne M. Cutts, Con Panousis, Andrew Masta, Don R. Phillips -- DNA polymerase inhibition assay (PIA) for the detection of drug-DNA interactions / Thomas P. Dooley, Katherine L. Weiland -- Transcriptional footprinting of drug-DNA interactions / Don R. Phillips, Carleen Cullinane -- Determination of the DNA sequence specificity of alkylation damage using cleavage-based assays / John A. Hartley, Michael D. Wyatt -- PCR-based methods for detecting DNA damage and its repair at the subgene and single nucleotide levels in cells / Keith A. Grimaldi, John A. Hartley -- Analysis of DNA-binding antibodies / Jeremy S. Lee, Laura J. Latimer, Jamshid Tanha -- Immunofluorescent staining of chromosomes with DNA-binding antibodies / Jeremy S. Lee, Laura J. Latimer, Gary D. Burkholder -- Optical absorbance and fluorescence techniques for measuring DNA-drug interactions / Terence C. Jenkins -- Evaluation of drug-nucleic acid interactions by thermal melting curves / W. David Wilson, Farial A. Tanious, Maria Fernandez-Saiz, C. Ted Rigl -- Electric dichroism / Dietmar Porschke -- Calorimetric techniques for studying drug-DNA interactions / Harry P. Hopkins -- Methods for the studies of drug dissociation from DNA / Fu-Ming Chen
Control code
230743523
Dimensions
unknown
Extent
1 online resource (x, 278 pages)
File format
one file format
Form of item
online
Isbn
9781592595747
Lccn
97217431
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1385/089603447X.
Other physical details
illustrations.
Quality assurance targets
unknown
Reproduction note
Electronic reproduction.
Specific material designation
remote
System control number
(OCoLC)230743523
System details
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.

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