The Resource Effects of ischemic metabolites and chronic exercise on cardiac myocyte function : a dissertation presented to the faculty of the Graduate School, University of Missouri-Columbia in partial fulfillment of the requirements for the degree Doctor of Philosophy, by Aaron C. Hinken ; Kerry S. McDonald, Ph.D., dissertation supervisor

Effects of ischemic metabolites and chronic exercise on cardiac myocyte function : a dissertation presented to the faculty of the Graduate School, University of Missouri-Columbia in partial fulfillment of the requirements for the degree Doctor of Philosophy, by Aaron C. Hinken ; Kerry S. McDonald, Ph.D., dissertation supervisor

Label
Effects of ischemic metabolites and chronic exercise on cardiac myocyte function : a dissertation presented to the faculty of the Graduate School, University of Missouri-Columbia in partial fulfillment of the requirements for the degree Doctor of Philosophy
Title
Effects of ischemic metabolites and chronic exercise on cardiac myocyte function
Title remainder
a dissertation presented to the faculty of the Graduate School, University of Missouri-Columbia in partial fulfillment of the requirements for the degree Doctor of Philosophy
Statement of responsibility
by Aaron C. Hinken ; Kerry S. McDonald, Ph.D., dissertation supervisor
Creator
Contributor
Author
Subject
Language
eng
Summary
During times of low blood flow (ischemia), concentrations of wastes increase in tissues, which can lead to decreased striated muscle contractile function. Acute cardiac contractile dysfunction during ischemia is likely mediated by build-up of inorganic phosphate (Pi) and protons (i.e., decreased pH). The focus of this dissertation is examination of the myofibrillar mechanisms by which ischemic metabolites alter the work capacity of cardiac myocytes, which ultimately comprise ventricular pump function. In addition, contractile properties and changes thereto with metabolite concentration were investigated in myocytes expressing either of the two isoforms of myosin heavy chain ([alpha]-MyHC and [beta]-MyHC), that show altered expression in response to chronic ischemia. Studies demonstrated differential response to metabolites with Pi and H+ alone and together decreasing power generating capacity of [alpha]-MyHC while only in combination did they diminished [beta]-MyHC myocyte power. The greater tolerance toward ischemic conditions in [beta]-MyHC myocytes was attributed to a Pi and H+ induced increase in the velocity of loaded shortening. In contrast to ischemia, changes following exercise training are thought to improve cardiac function. A pig model of exercise training was examined to determine if changes intrinsic to the myofilaments were partially responsible for changes in global cardiac function. Increased peak power generating capacity was observed in myocytes from exercise trained animals as compared to sedentary controls, which coincided with an increase in PKA-induced phosphorylation of myofibrillar proteins. Overall, these results provide evidence for myofibrillar mechanisms that, in part, underlie changes in myocardial performance associated with acute and chronic ventricular stress
Cataloging source
MMU
http://library.link/vocab/creatorDate
1977-
http://library.link/vocab/creatorName
Hinken, Aaron C.
Degree
Ph. D.
Dissertation year
2005.
http://bibfra.me/vocab/relation/dissertationsupervisor
GF0NB5hZ90U
Granting institution
University of Missouri-Columbia
Illustrations
illustrations
Index
no index present
LC call number
RB144
Literary form
non fiction
Nature of contents
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
McDonald, Kerry S.
http://library.link/vocab/subjectName
  • Ischemia
  • Heart
  • Animal models in research
  • Muscle cells
  • Muscle contraction
  • Myosin
  • Phosphates
  • Coronary Vessels
  • Ischemia
  • Models, Animal
  • Myocytes, Cardiac
  • Myofibrils
  • Myosins
  • Phosphates
Target audience
specialized
Label
Effects of ischemic metabolites and chronic exercise on cardiac myocyte function : a dissertation presented to the faculty of the Graduate School, University of Missouri-Columbia in partial fulfillment of the requirements for the degree Doctor of Philosophy, by Aaron C. Hinken ; Kerry S. McDonald, Ph.D., dissertation supervisor
Instantiates
Production
Note
  • Typescript
  • Includes vita
  • "May, 2005."
Bibliography note
Includes bibliographical references (leaves 112-122)
Carrier category
volume
Carrier category code
nc
Carrier MARC source
rdacarrier.
Content category
text
Content type code
txt
Content type MARC source
rdacontent.
Control code
878969420
Dimensions
29 cm
Extent
viii, 122 leaves
Media category
unmediated
Media MARC source
rdamedia.
Media type code
n
Other physical details
illustrations
System control number
(OCoLC)878969420
Label
Effects of ischemic metabolites and chronic exercise on cardiac myocyte function : a dissertation presented to the faculty of the Graduate School, University of Missouri-Columbia in partial fulfillment of the requirements for the degree Doctor of Philosophy, by Aaron C. Hinken ; Kerry S. McDonald, Ph.D., dissertation supervisor
Production
Note
  • Typescript
  • Includes vita
  • "May, 2005."
Bibliography note
Includes bibliographical references (leaves 112-122)
Carrier category
volume
Carrier category code
nc
Carrier MARC source
rdacarrier.
Content category
text
Content type code
txt
Content type MARC source
rdacontent.
Control code
878969420
Dimensions
29 cm
Extent
viii, 122 leaves
Media category
unmediated
Media MARC source
rdamedia.
Media type code
n
Other physical details
illustrations
System control number
(OCoLC)878969420

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