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The Resource Efficacy of nanoparticles in achieving hemostasis

Efficacy of nanoparticles in achieving hemostasis

Creator
Author
Summary
Uncontrollable hemorrhage is significant cause of preventable death in the military and civilian setting. Hemostatic wound dressings have been created in an attempt to rectify this problem, but none currently on the market are highly effective at controlling hemorrhage resulting in a need for an effective hemostatic wound dressing. This study investigated the effects of gold, silver, and silica nanoparticles on blood coagulation time in order to determine if nanoparticle incorporation into a hemostatic wound dressing would effectively achieve hemostasis. Gold, silver, and silica nanoparticles were experimented with two different ex vivo studies to determine their effects on coagulation. A modified Lee White Method and a rotational viscometer were utilized to assess the nanoparticles ability to clot blood. Results obtained from the modified Lee White Method proved inconsistent and inconclusive demonstrating a need for improved testing methods. Results acquired from viscometer testing demonstrated that silica was effective in decreasing coagulation time indicating its potential use as a hemostatic agent and its prospective incorporation into a hemostatic wound dressing
Language
eng
Work
Publication
Extent
1 online resource (x, 68 pages)
Note
Advisor: Sheila Ann Grant
Instance
Label
Efficacy of nanoparticles in achieving hemostasis
Title
Efficacy of nanoparticles in achieving hemostasis
Creator
Author
Subject
Language
eng
Summary
Uncontrollable hemorrhage is significant cause of preventable death in the military and civilian setting. Hemostatic wound dressings have been created in an attempt to rectify this problem, but none currently on the market are highly effective at controlling hemorrhage resulting in a need for an effective hemostatic wound dressing. This study investigated the effects of gold, silver, and silica nanoparticles on blood coagulation time in order to determine if nanoparticle incorporation into a hemostatic wound dressing would effectively achieve hemostasis. Gold, silver, and silica nanoparticles were experimented with two different ex vivo studies to determine their effects on coagulation. A modified Lee White Method and a rotational viscometer were utilized to assess the nanoparticles ability to clot blood. Results obtained from the modified Lee White Method proved inconsistent and inconclusive demonstrating a need for improved testing methods. Results acquired from viscometer testing demonstrated that silica was effective in decreasing coagulation time indicating its potential use as a hemostatic agent and its prospective incorporation into a hemostatic wound dressing
Cataloging source
MUU
http://library.link/vocab/creatorName
Schmitt, Carrie
Degree
M.S.
Dissertation note
Thesis
Dissertation year
2012.
Government publication
government publication of a state province territory dependency etc
Granting institution
University of Missouri--Columbia,
Index
no index present
Literary form
non fiction
Nature of contents
dictionaries
Label
Efficacy of nanoparticles in achieving hemostasis
Instantiates
Publication
Contributor
Thesis advisor
Note
Advisor: Sheila Ann Grant
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent.
Control code
876615382
Extent
1 online resource (x, 68 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)876615382
Label
Efficacy of nanoparticles in achieving hemostasis
Publication
Contributor
Thesis advisor
Note
Advisor: Sheila Ann Grant
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent.
Control code
876615382
Extent
1 online resource (x, 68 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)876615382

Subject

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