The Resource Electromagnetic stimulation of a composite scaffold for wound healing
Electromagnetic stimulation of a composite scaffold for wound healing
Resource Information
The item Electromagnetic stimulation of a composite scaffold for wound healing represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Missouri Libraries.This item is available to borrow from 1 library branch.
Resource Information
The item Electromagnetic stimulation of a composite scaffold for wound healing represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Missouri Libraries.
This item is available to borrow from 1 library branch.
- Summary
- Decellularized tissues have been investigated as natural sources for tissue scaffolds as synthetic mimicry of the natural extracellular matrix is quite difficult. In addition, gold nanomaterials have been studied for their ability to provide nanostructural cues for cell growth as well as their ability to interact with free radicals. Meanwhile, electromagnetic fields (EMFs) have been explored as an adjunct therapy for chronic wounds due to clinical evidence of wound healing enhancement. This dissertation investigated the incorporation of all three in the design and evaluation of an electromagnetically-stimulated composite scaffold comprised of decellularized porcine diaphragm and gold nanomaterials. Composite scaffolds were synthesized and characterized through biocompatibility, cell proliferation, and reactive oxygen species assays. The scaffolds were then subjected to an EMF while in cell culture to determine the cellular effects of this treatment. The results indicated the successful design of a biocompatible composite scaffold capable of free radical level modulation and enhanced cell proliferation, especially when subjected to an EMF. It was also shown that the interaction of the EMF and gold nanomaterials transiently enhanced cell spreading. Future studies are needed to elucidate the specific mechanisms for these effects and to further develop the system as an advanced wound therapy
- Language
- eng
- Extent
- 1 online resource (xiv, 185 pages)
- Note
- Advisor: Sheila Ann Grant
- Label
- Electromagnetic stimulation of a composite scaffold for wound healing
- Title
- Electromagnetic stimulation of a composite scaffold for wound healing
- Language
- eng
- Summary
- Decellularized tissues have been investigated as natural sources for tissue scaffolds as synthetic mimicry of the natural extracellular matrix is quite difficult. In addition, gold nanomaterials have been studied for their ability to provide nanostructural cues for cell growth as well as their ability to interact with free radicals. Meanwhile, electromagnetic fields (EMFs) have been explored as an adjunct therapy for chronic wounds due to clinical evidence of wound healing enhancement. This dissertation investigated the incorporation of all three in the design and evaluation of an electromagnetically-stimulated composite scaffold comprised of decellularized porcine diaphragm and gold nanomaterials. Composite scaffolds were synthesized and characterized through biocompatibility, cell proliferation, and reactive oxygen species assays. The scaffolds were then subjected to an EMF while in cell culture to determine the cellular effects of this treatment. The results indicated the successful design of a biocompatible composite scaffold capable of free radical level modulation and enhanced cell proliferation, especially when subjected to an EMF. It was also shown that the interaction of the EMF and gold nanomaterials transiently enhanced cell spreading. Future studies are needed to elucidate the specific mechanisms for these effects and to further develop the system as an advanced wound therapy
- Cataloging source
- MUU
- http://library.link/vocab/creatorName
- Cozad, Matthew
- Degree
- Ph. D.
- Dissertation note
- Thesis
- Dissertation year
- 2012.
- Government publication
- government publication of a state province territory dependency etc
- Granting institution
- University of Missouri--Columbia,
- Index
- no index present
- Literary form
- non fiction
- Nature of contents
- dictionaries
- Label
- Electromagnetic stimulation of a composite scaffold for wound healing
- Note
- Advisor: Sheila Ann Grant
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier.
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent.
- Control code
- 872568147
- Extent
- 1 online resource (xiv, 185 pages)
- Form of item
- online
- Media category
- computer
- Media MARC source
- rdamedia.
- Media type code
-
- c
- Specific material designation
- remote
- System control number
- (OCoLC)872569650
- Label
- Electromagnetic stimulation of a composite scaffold for wound healing
- Note
- Advisor: Sheila Ann Grant
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier.
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent.
- Control code
- 872568147
- Extent
- 1 online resource (xiv, 185 pages)
- Form of item
- online
- Media category
- computer
- Media MARC source
- rdamedia.
- Media type code
-
- c
- Specific material designation
- remote
- System control number
- (OCoLC)872569650
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<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.library.missouri.edu/portal/Electromagnetic-stimulation-of-a-composite/aw0Buz7xvqk/" typeof="Book http://bibfra.me/vocab/lite/Item"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.library.missouri.edu/portal/Electromagnetic-stimulation-of-a-composite/aw0Buz7xvqk/">Electromagnetic stimulation of a composite scaffold for wound healing</a></span> - <span property="potentialAction" typeOf="OrganizeAction"><span property="agent" typeof="LibrarySystem http://library.link/vocab/LibrarySystem" resource="http://link.library.missouri.edu/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.library.missouri.edu/">University of Missouri Libraries</a></span></span></span></span></div>
