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The Resource Electromagnetic stimulation of a composite scaffold for wound healing

Electromagnetic stimulation of a composite scaffold for wound healing

Label
Electromagnetic stimulation of a composite scaffold for wound healing
Title
Electromagnetic stimulation of a composite scaffold for wound healing
Creator
Author
Subject
Genre
Language
eng
Summary
Decellularized tissues have been investigated as natural sources for tissue scaffolds as synthetic mimicry of the natural extracellular matrix is quite difficult. In addition, gold nanomaterials have been studied for their ability to provide nanostructural cues for cell growth as well as their ability to interact with free radicals. Meanwhile, electromagnetic fields (EMFs) have been explored as an adjunct therapy for chronic wounds due to clinical evidence of wound healing enhancement. This dissertation investigated the incorporation of all three in the design and evaluation of an electromagnetically-stimulated composite scaffold comprised of decellularized porcine diaphragm and gold nanomaterials. Composite scaffolds were synthesized and characterized through biocompatibility, cell proliferation, and reactive oxygen species assays. The scaffolds were then subjected to an EMF while in cell culture to determine the cellular effects of this treatment. The results indicated the successful design of a biocompatible composite scaffold capable of free radical level modulation and enhanced cell proliferation, especially when subjected to an EMF. It was also shown that the interaction of the EMF and gold nanomaterials transiently enhanced cell spreading. Future studies are needed to elucidate the specific mechanisms for these effects and to further develop the system as an advanced wound therapy
Cataloging source
MUU
http://library.link/vocab/creatorName
Cozad, Matthew
Degree
Ph. D.
Dissertation note
Thesis
Dissertation year
2012.
Government publication
government publication of a state province territory dependency etc
Granting institution
University of Missouri--Columbia,
Index
no index present
Literary form
non fiction
Nature of contents
dictionaries
Label
Electromagnetic stimulation of a composite scaffold for wound healing
Instantiates
Publication
Contributor
Thesis advisor
Note
Advisor: Sheila Ann Grant
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
txt
Content type MARC source
rdacontent.
Control code
872568147
Extent
1 online resource (xiv, 185 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
c
Specific material designation
remote
System control number
(OCoLC)872569650
Label
Electromagnetic stimulation of a composite scaffold for wound healing
Publication
Contributor
Thesis advisor
Note
Advisor: Sheila Ann Grant
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
txt
Content type MARC source
rdacontent.
Control code
872568147
Extent
1 online resource (xiv, 185 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
c
Specific material designation
remote
System control number
(OCoLC)872569650

Library Locations

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      1020 Lowry Street, Columbia, MO, 65201, US
      38.944491 -92.326012
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