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The Resource Evaluating the suitability of the human toenail as a biomonitor for manganese status : the one source cohort, by James M. Guthrie, (electronic resource)

Evaluating the suitability of the human toenail as a biomonitor for manganese status : the one source cohort, by James M. Guthrie, (electronic resource)

Creator
Contributor
Summary
Numerous studies have demonstrated that the human toenail is a reliable biomonitor for the intake of Se and other elements. The objective of this study was to evaluate the hypothesis that Mn intake is reflected in toenail Mn levels. Interest in the status of Mn, a necessary trace nutrient which may also have toxic effects upon overexposure, stems from two recent developments: first, a greater awareness of the role of Mn-based enzymes in human health, and second, a renewed controversy over the use of a Mn-containing gasoline additive in Canada. In order to evaluate the hypothesis, toenail specimens from One Source multivitamin users and matched controls were selected. Using the NAA technique, Se was measured using established methods, and then Mn was measured via a new procedure. The Se results confirmed the accurate classification of the cohort. However, the nail did not demonstrate significant, positive response to Mn supplementation. Several explanations for this lack of response may be offered, including the confounding effect of other, unknown dietary variables; Mn blood level regulation by homeostatic mechanisms; and the masking of endogenous Mn in the toenail by persistent Seleniumexogenous material
Language
eng
Work
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from title screen of research.pdf file (viewed on October 25, 2007)
  • Vita
Instance
Label
Evaluating the suitability of the human toenail as a biomonitor for manganese status : the one source cohort
Title
Evaluating the suitability of the human toenail as a biomonitor for manganese status
Title remainder
the one source cohort
Statement of responsibility
by James M. Guthrie
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
Numerous studies have demonstrated that the human toenail is a reliable biomonitor for the intake of Se and other elements. The objective of this study was to evaluate the hypothesis that Mn intake is reflected in toenail Mn levels. Interest in the status of Mn, a necessary trace nutrient which may also have toxic effects upon overexposure, stems from two recent developments: first, a greater awareness of the role of Mn-based enzymes in human health, and second, a renewed controversy over the use of a Mn-containing gasoline additive in Canada. In order to evaluate the hypothesis, toenail specimens from One Source multivitamin users and matched controls were selected. Using the NAA technique, Se was measured using established methods, and then Mn was measured via a new procedure. The Se results confirmed the accurate classification of the cohort. However, the nail did not demonstrate significant, positive response to Mn supplementation. Several explanations for this lack of response may be offered, including the confounding effect of other, unknown dietary variables; Mn blood level regulation by homeostatic mechanisms; and the masking of endogenous Mn in the toenail by persistent Seleniumexogenous material
Cataloging source
MUU
http://library.link/vocab/creatorName
Guthrie, James McKamey
Degree
M.S.
Dissertation year
2007.
Granting institution
University of Missouri-Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorDate
1960-
http://library.link/vocab/relatedWorkOrContributorName
Robertson, John David
http://library.link/vocab/subjectName
  • Biological monitoring
  • Toenails
  • Selenium in human nutrition
  • Manganese in human nutrition
Target audience
specialized
Label
Evaluating the suitability of the human toenail as a biomonitor for manganese status : the one source cohort, by James M. Guthrie, (electronic resource)
Instantiates
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from title screen of research.pdf file (viewed on October 25, 2007)
  • Vita
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
mixed
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
176912802
Dimensions
unknown
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)176912802
System details
Mode of access: World Wide Web
Label
Evaluating the suitability of the human toenail as a biomonitor for manganese status : the one source cohort, by James M. Guthrie, (electronic resource)
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from title screen of research.pdf file (viewed on October 25, 2007)
  • Vita
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
mixed
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
176912802
Dimensions
unknown
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)176912802
System details
Mode of access: World Wide Web

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