Coverart for item
The Resource Evolution of translational omics : lessons learned and the path forward, Christine M. Micheel, Sharyl J. Nass, Gilbert S. Omenn, editors ; Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials, Board on Health Care Services, Board on Health Sciences Policy, Institute of Medicine of the National Academies

Evolution of translational omics : lessons learned and the path forward, Christine M. Micheel, Sharyl J. Nass, Gilbert S. Omenn, editors ; Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials, Board on Health Care Services, Board on Health Sciences Policy, Institute of Medicine of the National Academies

Label
Evolution of translational omics : lessons learned and the path forward
Title
Evolution of translational omics
Title remainder
lessons learned and the path forward
Statement of responsibility
Christine M. Micheel, Sharyl J. Nass, Gilbert S. Omenn, editors ; Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials, Board on Health Care Services, Board on Health Sciences Policy, Institute of Medicine of the National Academies
Contributor
Editor
Sponsoring body
Subject
Genre
Language
eng
Summary
Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials
Member of
Cataloging source
NLM
Dewey number
572.86
Funding information
This study was supported by Contract Nos. HHSN261200900003C (National Cancer Institute); HHSF223201010692P and HHSF22301018T (Food and Drug Administration); and 200-2011-38807 and 200-2005-13434 (Centers for Disease Control and Prevention). This study was also supported by the U.S. Department of Veterans Affairs, the American Society for Clinical Pathology, and the College of American Pathologists. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the organizations or agencies that provided support for this project.
Illustrations
illustrations
Index
no index present
LC call number
QH452.7
LC item number
.E86 2012eb
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • technical reports
NLM call number
  • 2014 I-900
  • QU 460
http://library.link/vocab/relatedWorkOrContributorName
  • Micheel, Christine
  • Nass, Sharyl J.
  • Omenn, Gilbert S.
  • Institute of Medicine (U.S.)
http://library.link/vocab/subjectName
  • Genomics
  • Genomics
  • Genetic translation
  • Biomolecules
  • Biomolecules
  • Bioinformatics
  • Data mining
  • Biotechnology
  • Genomics
  • Validation Studies as Topic
  • Molecular Diagnostic Techniques
  • Biotechnology
  • Translational Medical Research
  • SCIENCE
  • Biomolecules
  • Biotechnology
  • Genomics
Label
Evolution of translational omics : lessons learned and the path forward, Christine M. Micheel, Sharyl J. Nass, Gilbert S. Omenn, editors ; Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials, Board on Health Care Services, Board on Health Sciences Policy, Institute of Medicine of the National Academies
Instantiates
Publication
Note
Title from PDF title page
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Introduction -- Omics-based clinical discovery: science, technology and applications -- Best practices for omics-based test validation prior to use for patient management decisions in a clinical trial setting -- Evaluation of omics-based tests for clinical utility and use -- Responsible parties -- Lessons from the case studies
Control code
812528594
Dimensions
unknown
Extent
1 online resource (1 PDF file (xv, 338 pages)
Form of item
online
Isbn
9780309224192
Lccn
2012472477
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
9786613948861
Other physical details
illustrations
Specific material designation
remote
System control number
(OCoLC)812528594
Label
Evolution of translational omics : lessons learned and the path forward, Christine M. Micheel, Sharyl J. Nass, Gilbert S. Omenn, editors ; Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials, Board on Health Care Services, Board on Health Sciences Policy, Institute of Medicine of the National Academies
Publication
Note
Title from PDF title page
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Introduction -- Omics-based clinical discovery: science, technology and applications -- Best practices for omics-based test validation prior to use for patient management decisions in a clinical trial setting -- Evaluation of omics-based tests for clinical utility and use -- Responsible parties -- Lessons from the case studies
Control code
812528594
Dimensions
unknown
Extent
1 online resource (1 PDF file (xv, 338 pages)
Form of item
online
Isbn
9780309224192
Lccn
2012472477
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
9786613948861
Other physical details
illustrations
Specific material designation
remote
System control number
(OCoLC)812528594

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