The Resource Frequency domain fluorescent molecular tomography and molecular probes for small animal imaging, by Naresh Gandhi Kujala

Frequency domain fluorescent molecular tomography and molecular probes for small animal imaging, by Naresh Gandhi Kujala

Label
Frequency domain fluorescent molecular tomography and molecular probes for small animal imaging
Title
Frequency domain fluorescent molecular tomography and molecular probes for small animal imaging
Statement of responsibility
by Naresh Gandhi Kujala
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
In this thesis, we have developed a frequency domain fluorescent molecular tomographic system based on the heterodyne technique using a single source and detector pair for small animal imaging. In our system, the intensity of laser source is modulated to produce a diffuse photon density wave in the tissue. The phase of the diffuse photon density wave is measured by comparing the reference signal with the signal from tissue by using a phasemeter. In parallel, we have developed and evaluated fluorescent Alexa Fluor 680 and Alexa Fluor 750-Bombesin (BBN) probes to target gastrin-releasing peptide (GRP) receptors on prostate and breast cancer for optical molecular imaging. Confocal fluorescence microscopic imaging of the molecular probes for in vitro PC-3 prostate and T-47D breast cancer cell lines indicated specific uptake, internalization and receptor blocking of these probes. In vivo investigations in severely compromised immunodeficient (SCID) mice bearing xenografted PC-3 prostate and T47-D breast cancer lesions demonstrated the ability of this new molecular probes to specifically target tumor tissue with a high selectively and affinity
Cataloging source
MUU
http://library.link/vocab/creatorDate
1975-
http://library.link/vocab/creatorName
Kujala, Naresh Gandhi
Degree
Ph. D.
Dissertation year
2009
Granting institution
University of Missouri--Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorDate
1962 December-
http://library.link/vocab/relatedWorkOrContributorName
Yu, Ping
http://library.link/vocab/subjectName
  • Molecular probes
  • Animal models in research
  • Imaging systems in biology
  • Imaging systems in medicine
  • Tomography, Emission
  • Fluorescence spectroscopy
  • Animal models in research
  • Fluorescence spectroscopy
  • Imaging systems in biology
  • Imaging systems in medicine
  • Molecular probes
  • Tomography, Emission
Target audience
specialized
Label
Frequency domain fluorescent molecular tomography and molecular probes for small animal imaging, by Naresh Gandhi Kujala
Instantiates
Publication
Note
  • Title from PDF of title page (University of Missouri--Columbia, viewed on Feb 26, 2010)
  • The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file
  • Dissertation advisor: Dr. Ping Yu
  • Vita
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
607526334
Extent
1 online resource (xv, 111 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations (some color)
Specific material designation
remote
System control number
(OCoLC)607526334
Label
Frequency domain fluorescent molecular tomography and molecular probes for small animal imaging, by Naresh Gandhi Kujala
Publication
Note
  • Title from PDF of title page (University of Missouri--Columbia, viewed on Feb 26, 2010)
  • The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file
  • Dissertation advisor: Dr. Ping Yu
  • Vita
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
607526334
Extent
1 online resource (xv, 111 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations (some color)
Specific material designation
remote
System control number
(OCoLC)607526334

Library Locations

  • Ellis LibraryBorrow it
    1020 Lowry Street, Columbia, MO, 65201, US
    38.944491 -92.326012
  • Engineering Library & Technology CommonsBorrow it
    W2001 Lafferre Hall, Columbia, MO, 65211, US
    38.946102 -92.330125
  • Fisher Delta Research CenterBorrow it
    2-64 Agricultural Bldg, Columbia, MO, 65201, US
    38.958397 -92.303491
  • Geological Sciences LibraryBorrow it
    201 Geological Sciences, Columbia, MO, 65211, US
    38.947375 -92.329062
  • J. Otto Lottes Health Sciences LibraryBorrow it
    1 Hospital Dr, Columbia, MO, 65201, US
    38.939544 -92.328377
  • Journalism LibraryBorrow it
    102 Reynolds Jrnlism Institute, Columbia, MO, 65211, US
    38.947290 -92.328025
  • Mathematical Sciences LibraryBorrow it
    104 Ellis Library, Columbia, MO, 65201, US
    38.944377 -92.326537
  • University ArchivesBorrow it
    Columbia, MO, 65201, US
  • University Archives McAlester AnnexBorrow it
    703 Lewis Hall, Columbia, MO, 65211, US
    38.934630 -92.342290
  • University of Missouri Libraries DepositoryBorrow it
    2908 Lemone Blvd, Columbia, MO, 65211, US
    38.919360 -92.291620
  • Zalk Veterinary Medical LibraryBorrow it
    Veterinary Medicine West, Columbia, MO, 65211, US
    38.941099 -92.317911
Processing Feedback ...