The Resource Gene expression profiling for predicting outcomes in stage II colon cancer, prepared for Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by Blue Cross and Blue Shield Association Technology Evaluation Center, Evidence-based Practice Center ; investigators, Edgar R. Black, Louise Falzon, Naomi Aronson

Gene expression profiling for predicting outcomes in stage II colon cancer, prepared for Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by Blue Cross and Blue Shield Association Technology Evaluation Center, Evidence-based Practice Center ; investigators, Edgar R. Black, Louise Falzon, Naomi Aronson

Label
Gene expression profiling for predicting outcomes in stage II colon cancer
Title
Gene expression profiling for predicting outcomes in stage II colon cancer
Statement of responsibility
prepared for Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by Blue Cross and Blue Shield Association Technology Evaluation Center, Evidence-based Practice Center ; investigators, Edgar R. Black, Louise Falzon, Naomi Aronson
Creator
Contributor
Author
Issuing body
Sponsoring body
Subject
Genre
Language
eng
Summary
BACKGROUND: While adjuvant chemotherapy is recommended in patients with stage III colon cancer, its role in stage II disease is unclear. In treating 100 stage II patients with adjuvant chemotherapy, three or four will benefit, while others will suffer significant adverse effects. Research is underway to improve this decisionmaking. Gene expression profiling (GEP) is one of the techniques being studied. PURPOSE: The objective of this Technical Brief is to provide a summary of the state of the science on use of GEP in predicting outcomes, including benefit from adjuvant chemotherapy, in patients with stage II colon cancer. This Brief also summarizes key uncertainties. METHODS: Four guiding questions were used to frame this Technical Brief. A scan of the published literature through May 2012 identified studies describing the relationship between GEPs and outcomes in stage II colon cancer. Other sources included the U.S. Food and Drug Administration Web site, Key Informants, clinical trial Web sites, and scan of the grey literature. FINDINGS: Results have been published for GEP assays in stage II colon cancer; 13 GEP assays for prognosis, one GEP for prediction (reduced tumor recurrence from adjuvant therapy), and one microRNA profile for prognosis. Five GEP assays are available commercially. Published studies have not provided information related to clinical utility, the effect that using the GEP result in patient care has on net health outcome. Limited information was found for analytic validity. The current evidence does not provide the type of information needed to answer major questions about use of GEP assays in these patients. CONCLUSION: Although information is emerging about use of GEP assays to inform the decision about use of adjuvant chemotherapy in patients with stage II colon cancer, studies to date have not provided the type of information needed to address major uncertainties
Member of
Cataloging source
NLM
http://library.link/vocab/creatorName
Black, Edgar R
Funding information
Contract No. 290-2007-10058-I
Government publication
federal national government publication
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • technical reports
NLM call number
WI 529
http://library.link/vocab/relatedWorkOrContributorName
  • Falzon, Louise
  • Aronson, Naomi
  • United States
  • Blue Cross and Blue Shield Association
  • Effective Health Care Program (U.S.)
Series statement
  • Technical brief
  • AHRQ publication
Series volume
  • no. 13
  • no. 12(13)-EHC143-EF
http://library.link/vocab/subjectName
  • Colonic Neoplasms
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic
  • Chemotherapy, Adjuvant
  • Neoplasm Staging
  • Treatment Outcome
Label
Gene expression profiling for predicting outcomes in stage II colon cancer, prepared for Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by Blue Cross and Blue Shield Association Technology Evaluation Center, Evidence-based Practice Center ; investigators, Edgar R. Black, Louise Falzon, Naomi Aronson
Instantiates
Publication
Copyright
Note
"December 2012."
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
847111140
Extent
1 online resource (various pagings)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations.
Specific material designation
remote
System control number
(OCoLC)847111140
Label
Gene expression profiling for predicting outcomes in stage II colon cancer, prepared for Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by Blue Cross and Blue Shield Association Technology Evaluation Center, Evidence-based Practice Center ; investigators, Edgar R. Black, Louise Falzon, Naomi Aronson
Publication
Copyright
Note
"December 2012."
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
847111140
Extent
1 online resource (various pagings)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations.
Specific material designation
remote
System control number
(OCoLC)847111140

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