The Resource Hepatitis C viruses : genomes and molecular biology, edited by Seng-Lai Tan, (electronic resource)

Hepatitis C viruses : genomes and molecular biology, edited by Seng-Lai Tan, (electronic resource)

Label
Hepatitis C viruses : genomes and molecular biology
Title
Hepatitis C viruses
Title remainder
genomes and molecular biology
Statement of responsibility
edited by Seng-Lai Tan
Contributor
Subject
Language
eng
Summary
"Chronic hepatitis C is a serious public health problem and a disease burden in many parts of the world. The discovery of the causative agent, hepatitis C virus (HCV), in 1989 has initiated an almost unparalleled research activity in academic and pharmaceutical-industry laboratories over the ensuing years. This book aims to provide a state-of-the-art account of recent advances in the molecular and cellular biology, immunology and pathogenesis of HCV. It also aspires to discuss new strategies as well as outstanding issues for future research. Hepatitis C has been dubbed the "silent epidemic" because it is generally asymptomatic for decades after infection; its victims often are unaware of the infection until it is too late for therapy. What is the genetic makeup and molecular features that make HCV such a "silent" yet deadly assassin? This question, in fact, is the premise by which this monograph was prepared -- it was an attempt to decode the secrets of HCV, one viral gene at a time. To that end, we assembled a team of highly regarded experts from different disciplines who have prepared 16 chapters on various aspects of HCV, including the HCV genome and the role(s) of each viral gene product within the context of the viral life cycle, host interactions, and regulation of host antiviral defense and adaptive immunity."--home page
Cataloging source
XII
Dewey number
616.3623
Illustrations
illustrations
Index
index present
LC call number
QR201.H46
LC item number
H46 2006
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
QW 170
NLM item number
H52975 2006
http://library.link/vocab/relatedWorkOrContributorName
  • Tan, Seng-Lai
  • National Center for Biotechnology Information (U.S.)
http://library.link/vocab/subjectName
  • Hepatitis C virus
  • Hepacivirus
  • Genomics
  • Molecular Biology
Label
Hepatitis C viruses : genomes and molecular biology, edited by Seng-Lai Tan, (electronic resource)
Instantiates
Publication
Note
Title resource home page (viewed July 6, 2010)
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
HCV genome and life cycle -- HCV 5' and 3'UTR: when translation meets replication -- Assemble and interact: pleiotropic functions of the HCV core protein -- HCV glycoproteins: assembly of a functional E1-E2 heterodimer -- HCV NS2/3 protease -- HCV NS3-4A serine protease -- HCV helicase: structure, function, and inhibition -- HCV NS4B: from obscurity to central stage -- HCV NS5A: a multifunctional regulator of cellular pathways and virus replication -- Biochemical activities of the HCV NS5B RNA-dependent RNA polymerase -- HCV replicon systems -- Animal models for HCV study -- HCV regulation of host defense -- Regulation of adaptive immunity by HCV -- Recombinant vesicular stomatitis virus (VSV) and other strategies in HCV vaccine designs and immunotherapy -- Development of an infectious HCV cell culture system
Control code
243476301
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)243476301
Label
Hepatitis C viruses : genomes and molecular biology, edited by Seng-Lai Tan, (electronic resource)
Publication
Note
Title resource home page (viewed July 6, 2010)
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
HCV genome and life cycle -- HCV 5' and 3'UTR: when translation meets replication -- Assemble and interact: pleiotropic functions of the HCV core protein -- HCV glycoproteins: assembly of a functional E1-E2 heterodimer -- HCV NS2/3 protease -- HCV NS3-4A serine protease -- HCV helicase: structure, function, and inhibition -- HCV NS4B: from obscurity to central stage -- HCV NS5A: a multifunctional regulator of cellular pathways and virus replication -- Biochemical activities of the HCV NS5B RNA-dependent RNA polymerase -- HCV replicon systems -- Animal models for HCV study -- HCV regulation of host defense -- Regulation of adaptive immunity by HCV -- Recombinant vesicular stomatitis virus (VSV) and other strategies in HCV vaccine designs and immunotherapy -- Development of an infectious HCV cell culture system
Control code
243476301
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)243476301

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