The Resource Imaging techniques for treatment evaluation for metastatic breast cancer, investigators, Laura S Gold, Christoph I. Lee, Beth Devine, Heidi Nelson, Roger Chou, Scott Ramsey, Sean D. Sullivan

Imaging techniques for treatment evaluation for metastatic breast cancer, investigators, Laura S Gold, Christoph I. Lee, Beth Devine, Heidi Nelson, Roger Chou, Scott Ramsey, Sean D. Sullivan

Label
Imaging techniques for treatment evaluation for metastatic breast cancer
Title
Imaging techniques for treatment evaluation for metastatic breast cancer
Statement of responsibility
investigators, Laura S Gold, Christoph I. Lee, Beth Devine, Heidi Nelson, Roger Chou, Scott Ramsey, Sean D. Sullivan
Creator
Contributor
Author
Issuing body
Subject
Genre
Language
eng
Summary
BACKGROUND: Although multiple imaging modalities to evaluate treatment response in patients with metastatic breast cancer are used clinically, their comparative effectiveness has not been determined. PURPOSE: The purpose of this technical brief is to understand current utilization of metastatic breast imaging modalities for treatment evaluation in the United States, both in order to summarize the current state of the science and to inform future research on this topic. METHODS: We worked with Key Informants, including clinicians, patient advocates, representatives from the device manufacturing industry, and a product purchaser. Additionally, we searched gray and published literature from 2003 to 2013. We qualitatively synthesized the information from the Key Informant interviews and the gray literature. From the published literature, we abstracted data on the types of imaging used to evaluate treatment of metastatic breast cancer. FINDINGS: We identified bone scan (scintigraphy), magnetic resonance imaging (MRI), computed tomography (CT), and fluorodeoxyglucose-positron emission tomography (FDG-PET)/CT as the major modalities used for treatment evaluation of metastatic breast cancer in the United States. We also identified four types of imaging not commonly used currently that might become important within the next decade: F-fluoromisonidazole-(F-FMISO) PET/CT, fluorothymidine-(FLT) PET/CT, fluoroestradiol-(FES) PET/CT, and PET/MRI. All published reports pertaining to imaging evaluation of treatment response among metastatic breast cancer patients were limited to small observational studies. A review of the published literature found that, in general, uptake of tracers such as FDG in PET/CT scans is associated with tumor response as determined by bone scans, MRI, or CT. CONCLUSIONS: Literature pertaining to imaging evaluation of treatment response among metastatic breast cancer patients was limited. An important potential advantage of FDG-PET/CT over conventional imaging for assessing tumor response among metastatic breast cancer patients is that it provides functional information regarding tumor metabolism in addition to information on gross morphologic changes. While some early evidence suggests that the metabolic response assessed by FDG-PET/CT after initial cycles of chemotherapy may be predictive of response to treatment among metastatic breast cancer patients, more rigorous research is needed before definitive conclusions can be reached. Future research efforts should focus on identifying novel radiotracers and biomarkers that may clarify breast tumor biology, addressing the lack of information on patient-centered outcomes (e.g., patient preferences) related to imaging, better delineating clinical outcomes associated with treatment response identified by imaging (e.g., progression-free and overall survival), and determining the costs associated with frequent imaging for treatment response
Member of
Cataloging source
NLM
http://library.link/vocab/creatorName
Gold, Laura S
Funding information
Prepared for: Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services, 540 Gaither Road, Rockville, MD 20850; www.ahrq.gov. Contract No. 290-2012-00014-I. Prepared by: Pacific Northwest Evidence-based Practice Center, University of Washington and Oregon Health and Science University
Government publication
federal national government publication
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • technical reports
NLM call number
WP 870
http://library.link/vocab/relatedWorkOrContributorName
  • United States
  • Effective Health Care Program (U.S.)
  • Oregon Health & Science University
Series statement
  • Technical briefs
  • AHRQ publication
Series volume
  • number 17
  • no. 14-EHC044-EF
http://library.link/vocab/subjectName
  • Breast Neoplasms
  • Breast Neoplasms
  • Diagnostic Imaging
  • United States
  • United States
Label
Imaging techniques for treatment evaluation for metastatic breast cancer, investigators, Laura S Gold, Christoph I. Lee, Beth Devine, Heidi Nelson, Roger Chou, Scott Ramsey, Sean D. Sullivan
Instantiates
Publication
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
904423733
Extent
1 online resource (various pagings).
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)904423733
Label
Imaging techniques for treatment evaluation for metastatic breast cancer, investigators, Laura S Gold, Christoph I. Lee, Beth Devine, Heidi Nelson, Roger Chou, Scott Ramsey, Sean D. Sullivan
Publication
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
904423733
Extent
1 online resource (various pagings).
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)904423733

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