The Resource Immunotherapy for autoimmune diabetes, by Renu Jain, (electronic resource)

Immunotherapy for autoimmune diabetes, by Renu Jain, (electronic resource)

Label
Immunotherapy for autoimmune diabetes
Title
Immunotherapy for autoimmune diabetes
Statement of responsibility
by Renu Jain
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
Type I diabetes (TID) is an autoimmune disorder wherein the insulin producing beta (Beta) cells of the pancreatic islets of Langerhans are destroyed specifically by the [Beta]-cell antigen specific T cells. Numerous approaches have been tested in non obese diabetic (NOD) mouse, a commonly studied animal model of TID, to treat disease but very few have made it to clinical settings because of two main reasons. Firstly, most of the therapies are preventive and treat disease before the clinically diagnosable stage in humans and secondly, the interventions are non-antigen specific and induce a state of generalized immunosuppression. Two approaches have been developed to meet the above mentioned requisites for treatment of TID. In the first study, glutamic acid decarboxylase (GAD) sequence 206-220 (designated GAD2), representing a late stage diabetic epitope, was genetically incorporated into an Ig molecule to magnify tolerance. The resulting Ig-GAD2 could reverse TID when administered at the late hyperglycemic stage. More importantly, Ig-GAD2 cleared pancreatic cell infiltration and induced [Beta]-cell division. This was dependent on the induction of splenic IFN[Gamma] that inhibited pathogenic IL-17 production. In the second study, a tolerogenic population of NOD dendritic cells (DC) was identified that upon being loaded with diabetic antigens could mediate protection from disease in an antigen-specific manner. In fact, treatment with CD8[Alpha]-CD4-CD11c+ DC subset reduced destructive infiltration within the islets and induced protective T regulatory type 1 and CD4+CD25+Foxp3hi regulatory T cells. The protective function was due to the ability of DC to traffic efficiently to the non-inflammatory organ spleen and modulate autoreactive T cells
Cataloging source
MMU
http://library.link/vocab/creatorDate
1979-
http://library.link/vocab/creatorName
Jain, Renu
Degree
Ph. D.
Dissertation year
2008.
Granting institution
University of Missouri-Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
NLM call number
WK 825
http://library.link/vocab/relatedWorkOrContributorName
Zaghouani, Habib
http://library.link/vocab/subjectName
  • Diabetes
  • Diabetes
  • Diabetes
  • Genetic regulation
  • Dendritic cells
  • T cells
  • Interleukins
  • Macrophages
  • Diabetes Mellitus, Type 1
  • Diabetes Mellitus, Type 1
  • Dendritic Cells
  • Gene Expression Regulation
  • Interferon-gamma
  • Immunotherapy
  • Interleukin-17
  • Mice, Inbred NOD
  • T-Lymphocyte Subsets
Target audience
specialized
Label
Immunotherapy for autoimmune diabetes, by Renu Jain, (electronic resource)
Instantiates
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from PDF of title page (University of Missouri--Columbia, viewed on April 1, 2010)
  • Vita
  • Thesis advisor: Habib Zaghouani
  • "May 2008"
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
603560624
Extent
1 online resource (xi, 112 pages)
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
MU: Access is limited to the campus of the University of Missouri-Columbia.
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)603560624
Label
Immunotherapy for autoimmune diabetes, by Renu Jain, (electronic resource)
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from PDF of title page (University of Missouri--Columbia, viewed on April 1, 2010)
  • Vita
  • Thesis advisor: Habib Zaghouani
  • "May 2008"
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
603560624
Extent
1 online resource (xi, 112 pages)
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
MU: Access is limited to the campus of the University of Missouri-Columbia.
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)603560624

Library Locations

    • Ellis LibraryBorrow it
      1020 Lowry Street, Columbia, MO, 65201, US
      38.944491 -92.326012
    • J. Otto Lottes Health Sciences LibraryBorrow it
      1 Hospital Dr, Columbia, MO, 65201, US
      38.939544 -92.328377
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