The Resource Improving and accelerating therapeutic development for nervous system disorders : workshop summary, Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy ; Sheena M. Posey Norris, Diana E. Pankevich, Miriam Davis, and Bruce M. Altevogt, rapporteurs ; Institute of Medicine of the National Academies

Improving and accelerating therapeutic development for nervous system disorders : workshop summary, Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy ; Sheena M. Posey Norris, Diana E. Pankevich, Miriam Davis, and Bruce M. Altevogt, rapporteurs ; Institute of Medicine of the National Academies

Label
Improving and accelerating therapeutic development for nervous system disorders : workshop summary
Title
Improving and accelerating therapeutic development for nervous system disorders
Title remainder
workshop summary
Statement of responsibility
Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy ; Sheena M. Posey Norris, Diana E. Pankevich, Miriam Davis, and Bruce M. Altevogt, rapporteurs ; Institute of Medicine of the National Academies
Title variation
Therapeutic development for nervous system disorders
Creator
Contributor
Issuing body
Subject
Genre
Language
eng
Summary
"Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials"--Publisher's description
Cataloging source
COO
Illustrations
illustrations
Index
no index present
LC call number
RC350.C54
Literary form
non fiction
http://bibfra.me/vocab/lite/meetingDate
2013
http://bibfra.me/vocab/lite/meetingName
Accelerating Therapeutic Development for Nervous System Disorders Toward First-in-Human Trials (Workshop)
Nature of contents
  • dictionaries
  • bibliography
NLM call number
QV 76.5
http://bibfra.me/vocab/relation/rapporteur
  • eHHoKvOxA1s
  • dGTZd7WN2Do
  • dL0G31WNya8
http://library.link/vocab/relatedWorkOrContributorDate
1975-
http://library.link/vocab/relatedWorkOrContributorName
  • Norris, Sheena M. Posey
  • Pankevich, Diana E.
  • Davis, Miriam
  • Institute of Medicine (U.S.)
http://library.link/vocab/subjectName
  • Nervous system
  • Drug development
  • Drug approval
  • Clinical trials
  • Drug Design
  • Nervous System Diseases
  • Clinical Trials as Topic
  • Drug Approval
Label
Improving and accelerating therapeutic development for nervous system disorders : workshop summary, Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy ; Sheena M. Posey Norris, Diana E. Pankevich, Miriam Davis, and Bruce M. Altevogt, rapporteurs ; Institute of Medicine of the National Academies
Instantiates
Publication
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
txt
Content type MARC source
rdacontent.
Contents
Introduction and overview -- Drug development challenges -- Target identification -- Target validation -- Opportunities to improve and accelerate the drug development pipeline -- Perspectives on next steps
Control code
870331093
Extent
1 online resource (118 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
c
Other physical details
color illustrations.
Specific material designation
remote
System control number
(OCoLC)870331093
Label
Improving and accelerating therapeutic development for nervous system disorders : workshop summary, Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy ; Sheena M. Posey Norris, Diana E. Pankevich, Miriam Davis, and Bruce M. Altevogt, rapporteurs ; Institute of Medicine of the National Academies
Publication
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
txt
Content type MARC source
rdacontent.
Contents
Introduction and overview -- Drug development challenges -- Target identification -- Target validation -- Opportunities to improve and accelerate the drug development pipeline -- Perspectives on next steps
Control code
870331093
Extent
1 online resource (118 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
c
Other physical details
color illustrations.
Specific material designation
remote
System control number
(OCoLC)870331093

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