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The Resource In situ polymerizing collagen for the development of 3D printed tissue engineering scaffolds, by Christopher John Glover

In situ polymerizing collagen for the development of 3D printed tissue engineering scaffolds, by Christopher John Glover

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Author
Contributor
Summary
Natural materials have been processed and utilized as scaffold materials in the field of tissue engineering for many years. One natural material often utilized is collagen since it is the main structural protein in mammalian tissues and exhibits microstructures suitable for the survival and proliferation of many different cell lineages. However, a common challenge with fibrillized collagen is the difficulty associated with trying to process it into specific three-dimensional designs for the development of scaffolds aimed at regenerating particular tissue types. This project consists of utilizing a custom platform capable of 3D printing in situ polymerizing collagen into user-defined morphologies for the development of 3D collagen-based scaffolds. Various anti-inflammatory compounds such as gold nanoparticles and curcumin were also incorporated into the scaffolds post printing in order to further tailor the cellular responses to the scaffolds. Scanning electron microscopy and neutron activation analysis were performed to verify and quantify the attachment of the gold nanoparticles, respectively. Differential scanning calorimetry was utilized to examine and optimize the stability of the scaffolds after crosslinking. Lastly, water soluble tetrazolium salt and reactive oxygen species assays were performed to assess the biocompatibility of the scaffolds using L929 murine fibroblasts. The results exhibited the viability of the platform to become an effective technique to manufacture and process custom scaffolds for tissue engineering applications
Language
eng
Work
Publication
Extent
1 online resource (ix, 76 pages)
Note
  • Field of study: Biological engineering
  • Dr. Sheila Grant, Thesis Supervisor
Instance
Label
In situ polymerizing collagen for the development of 3D printed tissue engineering scaffolds
Title
In situ polymerizing collagen for the development of 3D printed tissue engineering scaffolds
Statement of responsibility
by Christopher John Glover
Creator
Contributor
Author
Degree supervisor
Subject
Genre
Language
eng
Summary
Natural materials have been processed and utilized as scaffold materials in the field of tissue engineering for many years. One natural material often utilized is collagen since it is the main structural protein in mammalian tissues and exhibits microstructures suitable for the survival and proliferation of many different cell lineages. However, a common challenge with fibrillized collagen is the difficulty associated with trying to process it into specific three-dimensional designs for the development of scaffolds aimed at regenerating particular tissue types. This project consists of utilizing a custom platform capable of 3D printing in situ polymerizing collagen into user-defined morphologies for the development of 3D collagen-based scaffolds. Various anti-inflammatory compounds such as gold nanoparticles and curcumin were also incorporated into the scaffolds post printing in order to further tailor the cellular responses to the scaffolds. Scanning electron microscopy and neutron activation analysis were performed to verify and quantify the attachment of the gold nanoparticles, respectively. Differential scanning calorimetry was utilized to examine and optimize the stability of the scaffolds after crosslinking. Lastly, water soluble tetrazolium salt and reactive oxygen species assays were performed to assess the biocompatibility of the scaffolds using L929 murine fibroblasts. The results exhibited the viability of the platform to become an effective technique to manufacture and process custom scaffolds for tissue engineering applications
Cataloging source
MUU
http://library.link/vocab/creatorName
Glover, Christopher John
Degree
M.S.
Dissertation note
Thesis
Dissertation year
2018.
Government publication
government publication of a state province territory dependency etc
Granting institution
University of Missouri--Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
Grant, Sheila Ann
http://library.link/vocab/subjectName
  • Tissue engineering
  • Tissue scaffolds
  • Three-dimensional printing
Label
In situ polymerizing collagen for the development of 3D printed tissue engineering scaffolds, by Christopher John Glover
Instantiates
Publication
Note
  • Field of study: Biological engineering
  • Dr. Sheila Grant, Thesis Supervisor
Bibliography note
Includes bibliographical references (page 71)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
1099182748
Extent
1 online resource (ix, 76 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (chiefly color)
Specific material designation
remote
System control number
(OCoLC)1099182748
Label
In situ polymerizing collagen for the development of 3D printed tissue engineering scaffolds, by Christopher John Glover
Publication
Note
  • Field of study: Biological engineering
  • Dr. Sheila Grant, Thesis Supervisor
Bibliography note
Includes bibliographical references (page 71)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
1099182748
Extent
1 online resource (ix, 76 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (chiefly color)
Specific material designation
remote
System control number
(OCoLC)1099182748

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