Coverart for item
The Resource In vitro neurotoxicology : principles and challenges, edited by Evelyn Tiffany-Castiglioni

In vitro neurotoxicology : principles and challenges, edited by Evelyn Tiffany-Castiglioni

Label
In vitro neurotoxicology : principles and challenges
Title
In vitro neurotoxicology
Title remainder
principles and challenges
Statement of responsibility
edited by Evelyn Tiffany-Castiglioni
Contributor
Subject
Language
eng
Summary
Neurotoxicity assessment with in vitro systems offers not only a means to better understand mechanisms of action of toxicants and decrease reliance on laboratory animals, but also provides a basis for reliable, high throughput screening of new and untested chemicals. In In Vitro Neurotoxicology: Principles and Challenges, well-respected leaders in the field take a fresh look at their own and others' work, critically and comparatively analyzing it across experimental systems and toxicants, and synthesizing essential principles for in vitro neurotoxicity testing. In thematically organized chapters, the authors employ examples comprised of multiple experimental systems and endpoints, and discuss the use of complementary in vivo/in vitro strategies. Neurotoxicants of significance to human health are emphasized, especially those for which metabolism and dose-responses are well studied both in vivo and in vitro: lead, mercury, organophosphorus insecticides, polychlorinated biphenyls and dioxin, ethanol, and endogenous proteins. Several neurotoxicology topics covered provide insight into neurodevelopmental and neurodegenerative diseases, including the concept of astroglia as depots for lead and other metals in the central nervous system, the elucidation of factors involved in the onset of puberty in females, and the exploration of endogenous proteins as neurotoxicants. Authoritative and forward-looking, In Vitro Neurotoxicology: Principles and Challenges sets out new concepts and research directions that will facilitate significant improvement in today's methods and systems for in vitro neurotoxicity testing
Member of
Cataloging source
COO
Dewey number
616.8/047
Illustrations
illustrations
Index
index present
LC call number
RC347.5
LC item number
.T54 2004
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
  • 2004 B-076
  • QW 630.5.N4
NLM item number
T565i 2004
http://library.link/vocab/relatedWorkOrContributorName
Tiffany-Castiglioni, Evelyn
Series statement
Methods in pharmacology and toxicology
http://library.link/vocab/subjectName
  • Neurotoxicology
  • Toxicity testing
  • Neurotoxins
  • Neurotoxicity Syndromes
  • Toxicity Tests
  • HEALTH & FITNESS
  • MEDICAL
  • Neurotoxicology
  • Toxicity testing
Label
In vitro neurotoxicology : principles and challenges, edited by Evelyn Tiffany-Castiglioni
Instantiates
Publication
Bibliography note
  • "Annotated reading list": pages 315-323
  • Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Cover -- Dedication -- Foreword -- Preface -- Contents -- 1 In Vitro Neurotoxicology: Introduction to Concepts -- 2 Predictive Value of In Vitro Systems for Neurotoxicity Risk Assessment -- 3 Exposure ... Dose ... Response Paradigm as It Relates to Toxicogenomics -- 4 In Vitro Studies of Neurotoxicant Effects on Cellular Homeostasis -- 5 Role of Apoptosis in Neurotoxicology -- 6 Impairment of Neurotransmitter Metabolism and Function by Neurotoxicants: Enzyme Pathways in Neurons and Astroglia -- 7 Cell-Type Specific Responses of the Nervous System to Lead -- 8 Effects of Toxicants on Neural Differentiation -- 9 Impairment of Synaptic Function by Exposure to Lead -- 10 Aggregating Brain Cell Cultures for Neurotoxicological Studies -- 11 Use of Complimentary In Vitro and In Vivo Methods for Assessing Neuroendocrine Disruptors -- 12 Establishing In Vitro Models Study Endogenous Neurotoxicants -- Appendix: Annotated Reading List
Control code
54760131
Dimensions
unknown
Extent
1 online resource (xv, 331 pages)
Form of item
online
Isbn
9781592596515
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1385/1592596517
Other physical details
illustrations.
Specific material designation
remote
System control number
(OCoLC)54760131
Label
In vitro neurotoxicology : principles and challenges, edited by Evelyn Tiffany-Castiglioni
Publication
Bibliography note
  • "Annotated reading list": pages 315-323
  • Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Cover -- Dedication -- Foreword -- Preface -- Contents -- 1 In Vitro Neurotoxicology: Introduction to Concepts -- 2 Predictive Value of In Vitro Systems for Neurotoxicity Risk Assessment -- 3 Exposure ... Dose ... Response Paradigm as It Relates to Toxicogenomics -- 4 In Vitro Studies of Neurotoxicant Effects on Cellular Homeostasis -- 5 Role of Apoptosis in Neurotoxicology -- 6 Impairment of Neurotransmitter Metabolism and Function by Neurotoxicants: Enzyme Pathways in Neurons and Astroglia -- 7 Cell-Type Specific Responses of the Nervous System to Lead -- 8 Effects of Toxicants on Neural Differentiation -- 9 Impairment of Synaptic Function by Exposure to Lead -- 10 Aggregating Brain Cell Cultures for Neurotoxicological Studies -- 11 Use of Complimentary In Vitro and In Vivo Methods for Assessing Neuroendocrine Disruptors -- 12 Establishing In Vitro Models Study Endogenous Neurotoxicants -- Appendix: Annotated Reading List
Control code
54760131
Dimensions
unknown
Extent
1 online resource (xv, 331 pages)
Form of item
online
Isbn
9781592596515
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1385/1592596517
Other physical details
illustrations.
Specific material designation
remote
System control number
(OCoLC)54760131

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