The Resource Inflammation and the microcirculation, D. Neil Granger, Elena Senchenkova

Inflammation and the microcirculation, D. Neil Granger, Elena Senchenkova

Label
Inflammation and the microcirculation
Title
Inflammation and the microcirculation
Statement of responsibility
D. Neil Granger, Elena Senchenkova
Creator
Contributor
Author
Subject
Language
eng
Summary
The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation
Member of
Cataloging source
NLM
http://library.link/vocab/creatorName
Granger, D. Neil
Dewey number
616.14
Illustrations
illustrations
Index
no index present
LC call number
RB131
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
  • 2012 B-853
  • QW 700
http://library.link/vocab/relatedWorkOrContributorName
Senchenkova, Elena
Series statement
Colloquium series in integrated systems physiology : from molecule to function,
Series volume
Book #8
http://library.link/vocab/subjectName
  • Inflammation
  • Microcirculation
  • Inflammation
  • Capillary Permeability
  • Cell Adhesion Molecules
  • Microcirculation
  • MEDICAL / Cardiology
  • Inflammation
  • Microcirculation
Label
Inflammation and the microcirculation, D. Neil Granger, Elena Senchenkova
Instantiates
Publication
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent.
Contents
Introduction -- Historical perspectives -- Anatomical considerations -- Impaired vasomotor responses -- Impaired vasomotor responses -- Capillary perfusion -- Angiogenesis -- Leukocyte-endothelial cell adhesion -- Endothelial barrier dysfunction
Control code
698212843
Extent
1 online resource
Form of item
online
Isbn
9781615041664
Media category
computer
Media MARC source
rdamedia.
Media type code
  • c
Other control number
10.4199/C00013ED1V01Y201006ISP008
Other physical details
illustrations (some color)
Specific material designation
remote
System control number
(OCoLC)698212843
Label
Inflammation and the microcirculation, D. Neil Granger, Elena Senchenkova
Publication
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent.
Contents
Introduction -- Historical perspectives -- Anatomical considerations -- Impaired vasomotor responses -- Impaired vasomotor responses -- Capillary perfusion -- Angiogenesis -- Leukocyte-endothelial cell adhesion -- Endothelial barrier dysfunction
Control code
698212843
Extent
1 online resource
Form of item
online
Isbn
9781615041664
Media category
computer
Media MARC source
rdamedia.
Media type code
  • c
Other control number
10.4199/C00013ED1V01Y201006ISP008
Other physical details
illustrations (some color)
Specific material designation
remote
System control number
(OCoLC)698212843

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