The Resource Metformin use in patients with historical contraindications or precautions, prepared for Department of Veterans Affairs, Veterans Health Administration, Quality Enhancement Research Initiative, Health Services Research & Development Service ; prepared by Evidence-based Synthesis Program (ESP) Center, Durham VA Medical Center ; principal investigators, Matthew J. Crowley, Clarissa J. Diamantidis, John W. Williams, Jr. ; co-investigators, Jennifer R. McDuffie [and six others] ; research associates, Avishek Nagi, Liz Wing

Metformin use in patients with historical contraindications or precautions, prepared for Department of Veterans Affairs, Veterans Health Administration, Quality Enhancement Research Initiative, Health Services Research & Development Service ; prepared by Evidence-based Synthesis Program (ESP) Center, Durham VA Medical Center ; principal investigators, Matthew J. Crowley, Clarissa J. Diamantidis, John W. Williams, Jr. ; co-investigators, Jennifer R. McDuffie [and six others] ; research associates, Avishek Nagi, Liz Wing

Label
Metformin use in patients with historical contraindications or precautions
Title
Metformin use in patients with historical contraindications or precautions
Statement of responsibility
prepared for Department of Veterans Affairs, Veterans Health Administration, Quality Enhancement Research Initiative, Health Services Research & Development Service ; prepared by Evidence-based Synthesis Program (ESP) Center, Durham VA Medical Center ; principal investigators, Matthew J. Crowley, Clarissa J. Diamantidis, John W. Williams, Jr. ; co-investigators, Jennifer R. McDuffie [and six others] ; research associates, Avishek Nagi, Liz Wing
Title variation
QUERI
Creator
Contributor
Author
Sponsoring body
Subject
Genre
Language
eng
Summary
Metformin is a biguanide oral hypoglycemic used primarily for treating type 2 diabetes mellitus (T2D). Evidence suggests that, in addition to improving glycemic control, metformin is associated with improved all-cause and cardiovascular mortality and decreased risk of some cancers. However, clinicians have been advised by the U.S. Food and Drug Administration (FDA) to exercise caution in prescribing metformin to individuals with chronic kidney disease (CKD), unstable congestive heart failure (CHF), chronic liver disease (CLD), and older age due to perceived risk of side effects, including lactic acidosis (LA). Recent literature highlights the rarity of metformin-associated LA and supports the cautious expansion of metformin use. In addition, in April 2016 the FDA modified its position on CKD to extend use of metformin to some patients with moderate CKD. Yet there remain uncertainties regarding the risks and benefits of metformin use in populations with CKD, CHF, CLD, and older age. For this reason, we conducted a systematic review and meta-analysis in order to determine the answers to the following key questions: KQ 1. For patients with type 2 diabetes and an apparent contraindication or precaution to metformin use (eg, renal insufficiency, congestive heart failure, chronic liver disease, or older age): 1. What is the rate of lactic acidosis in patients taking metformin?2. How does the rate of lactic acidosis in patients taking metformin compare with the rate in patients taking other hypoglycemics?KQ 2. For patients with type 2 diabetes and an apparent contraindication or precaution to metformin use, what are the potential benefits and harms (other than lactic acidosis) of continued treatment with metformin?
Member of
Cataloging source
MMU
http://library.link/vocab/creatorName
Crowley, Matthew J
Government publication
federal national government publication
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
WK 825
http://library.link/vocab/relatedWorkOrContributorName
  • Quality Enhancement Research Initiative (U.S.)
  • United States
  • Durham VA Medical Center
Series statement
Evidence-based synthesis program
http://library.link/vocab/subjectName
  • Diabetes Mellitus, Type 2
  • Metformin
  • Hypoglycemic Agents
  • Metformin
  • Hypoglycemic Agents
  • Risk Assessment
  • United States
  • Contraindications
  • United States
Label
Metformin use in patients with historical contraindications or precautions, prepared for Department of Veterans Affairs, Veterans Health Administration, Quality Enhancement Research Initiative, Health Services Research & Development Service ; prepared by Evidence-based Synthesis Program (ESP) Center, Durham VA Medical Center ; principal investigators, Matthew J. Crowley, Clarissa J. Diamantidis, John W. Williams, Jr. ; co-investigators, Jennifer R. McDuffie [and six others] ; research associates, Avishek Nagi, Liz Wing
Instantiates
Publication
Note
  • "September 2016."
  • "VA-ESP Project # 09-010."
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
  • text
  • still image
Content type code
  • txt
  • sti
Content type MARC source
  • rdacontent
  • rdacontent
Control code
973950339
Extent
1 online resource (iii, 82 pages, 1 unnumbered pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations.
Specific material designation
remote
System control number
(OCoLC)973950339
Label
Metformin use in patients with historical contraindications or precautions, prepared for Department of Veterans Affairs, Veterans Health Administration, Quality Enhancement Research Initiative, Health Services Research & Development Service ; prepared by Evidence-based Synthesis Program (ESP) Center, Durham VA Medical Center ; principal investigators, Matthew J. Crowley, Clarissa J. Diamantidis, John W. Williams, Jr. ; co-investigators, Jennifer R. McDuffie [and six others] ; research associates, Avishek Nagi, Liz Wing
Publication
Note
  • "September 2016."
  • "VA-ESP Project # 09-010."
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
  • text
  • still image
Content type code
  • txt
  • sti
Content type MARC source
  • rdacontent
  • rdacontent
Control code
973950339
Extent
1 online resource (iii, 82 pages, 1 unnumbered pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations.
Specific material designation
remote
System control number
(OCoLC)973950339

Library Locations

  • Ellis LibraryBorrow it
    1020 Lowry Street, Columbia, MO, 65201, US
    38.944491 -92.326012
  • Engineering Library & Technology CommonsBorrow it
    W2001 Lafferre Hall, Columbia, MO, 65211, US
    38.946102 -92.330125
  • Fisher Delta Research CenterBorrow it
    2-64 Agricultural Bldg, Columbia, MO, 65201, US
    38.958397 -92.303491
  • Geological Sciences LibraryBorrow it
    201 Geological Sciences, Columbia, MO, 65211, US
    38.947375 -92.329062
  • J. Otto Lottes Health Sciences LibraryBorrow it
    1 Hospital Dr, Columbia, MO, 65201, US
    38.939544 -92.328377
  • Journalism LibraryBorrow it
    102 Reynolds Jrnlism Institute, Columbia, MO, 65211, US
    38.947290 -92.328025
  • Mathematical Sciences LibraryBorrow it
    104 Ellis Library, Columbia, MO, 65201, US
    38.944377 -92.326537
  • University ArchivesBorrow it
    Columbia, MO, 65201, US
  • University Archives McAlester AnnexBorrow it
    703 Lewis Hall, Columbia, MO, 65211, US
    38.934630 -92.342290
  • University of Missouri Libraries DepositoryBorrow it
    2908 Lemone Blvd, Columbia, MO, 65211, US
    38.919360 -92.291620
  • Zalk Veterinary Medical LibraryBorrow it
    Veterinary Medicine West, Columbia, MO, 65211, US
    38.941099 -92.317911
Processing Feedback ...