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The Resource Molecular analysis of cancer, edited by Jacqueline Boultwood and Carrie Fidler

Molecular analysis of cancer, edited by Jacqueline Boultwood and Carrie Fidler

Contributor
Summary
Molecular biotechnology has in recent years produced significant advances in finding tumor markers useful in diagnosis and in the assessment of disease progression and prognosis. In Molecular Analysis of Cancer, leading researchers in the field describe in step-by-step detail their best state-of-the-art molecular techniques for elucidating the biochemical processes associated with human cancer. Among the techniques presented for identifying chromosomal rearrangements are fluorescent in situ hybridization (FISH), spectral karyotyping (SKY), comparative genomic hybridization (CGH), microsatellite analysis, PCR and RT-PCR, and DNA fingerprinting. Additional methods include SSCP, DGGE, the nonisotopic RNase cleavage assay, and the protein truncation assay and DNA sequencing for identifying mutations. Techniques for the analysis of gene expression include microarray technology and differential display. All these techniques are of great value for identifying genes that are central to cancer development and progression. Comprehensive and state-of-the-art, Molecular Analysis of Cancer not only offers today's researcher a deeper understanding of cancer's molecular pathogenesis, but also provides a detailed examination of each of the major methodologies needed to detect and analyze its associated genetic abnormalities
Language
eng
Work
Publication
Extent
1 online resource (xi, 302 pages)
Contents
  • Molecular analysis of cancer. An overview
  • Detection of chromosome abnormalities in leukemia using fluorescence in situ hybridization
  • Spectral karyotyping in cancer cytogenetics
  • Comparative genomic hybridization analysis
  • Detection of chromosomal deletions by microsatellite analysis
  • Detection and quantification of leukemia-specific rearrangements
  • Detection of t(2;5)(p23;q35) translocation by long-range PCR of genomic DNA
  • Use of DNA fingerprinting to detect genetic rearrangements in human cancer
  • Mutation analysis of large genomic regions in tumor DNA using single-strand conformation polymorphism. Lessons from the ATM gene
  • Mutational analysis of oncogenes and tumor suppressor genes in human cancer using denaturing gradient gel electrophoresis
  • Detection of mutations in human cancer using nonisotopic RNase cleavage assay
  • Mutational analysis of the neurofibromatosis type 1 gene in childhood myelodysplastic syndromes using a protein truncation assay
  • Mutation analysis of cancer using automated sequencing
  • Detection of differentially expressed genes in cancer using differential display
  • Genomewide gene expression analysis using cDNA microarrays
  • Gene expression profiling in cancer using cDNA microarrays
  • Wilms tumor gene WT1 as a tumor marker for leukemic blast cells and its role in leukemogenesis
  • Detection of aberrant methylation of the p15INK4B gene promoter
  • Clonality studies in cancer based on X chromosome inactivation phenomenon
  • Telomere length changes in human cancer
  • Measurement of telomerase activity in human hematopoietic cells and neoplastic disorders
Isbn
9780585438917
Instance
Label
Molecular analysis of cancer
Title
Molecular analysis of cancer
Statement of responsibility
edited by Jacqueline Boultwood and Carrie Fidler
Contributor
Subject
Language
eng
Summary
Molecular biotechnology has in recent years produced significant advances in finding tumor markers useful in diagnosis and in the assessment of disease progression and prognosis. In Molecular Analysis of Cancer, leading researchers in the field describe in step-by-step detail their best state-of-the-art molecular techniques for elucidating the biochemical processes associated with human cancer. Among the techniques presented for identifying chromosomal rearrangements are fluorescent in situ hybridization (FISH), spectral karyotyping (SKY), comparative genomic hybridization (CGH), microsatellite analysis, PCR and RT-PCR, and DNA fingerprinting. Additional methods include SSCP, DGGE, the nonisotopic RNase cleavage assay, and the protein truncation assay and DNA sequencing for identifying mutations. Techniques for the analysis of gene expression include microarray technology and differential display. All these techniques are of great value for identifying genes that are central to cancer development and progression. Comprehensive and state-of-the-art, Molecular Analysis of Cancer not only offers today's researcher a deeper understanding of cancer's molecular pathogenesis, but also provides a detailed examination of each of the major methodologies needed to detect and analyze its associated genetic abnormalities
Member of
Is part of
Action
digitized
Cataloging source
COO
Dewey number
616.99/4042
Illustrations
illustrations
Index
index present
Language note
English
LC call number
RC268.4
LC item number
.M627 2002
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
QZ 200
NLM item number
M7175 2001
http://library.link/vocab/relatedWorkOrContributorName
  • Boultwood, Jacqueline
  • Fidler, Carrie
Series statement
Methods in molecular medicine
Series volume
68
http://library.link/vocab/subjectName
  • Cancer
  • Cancer
  • Neoplasms
  • Cell Transformation, Neoplastic
  • Gene Expression Regulation, Neoplastic
  • Genetic Techniques
  • MEDICAL
  • HEALTH & FITNESS
  • Medicine
  • Pathology
  • Krebs
  • Molekulare Medizin
  • Kanker
  • Moleculaire biologie
  • Wetenschappelijke technieken
Label
Molecular analysis of cancer, edited by Jacqueline Boultwood and Carrie Fidler
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Molecular analysis of cancer. An overview -- Detection of chromosome abnormalities in leukemia using fluorescence in situ hybridization -- Spectral karyotyping in cancer cytogenetics -- Comparative genomic hybridization analysis -- Detection of chromosomal deletions by microsatellite analysis -- Detection and quantification of leukemia-specific rearrangements -- Detection of t(2;5)(p23;q35) translocation by long-range PCR of genomic DNA -- Use of DNA fingerprinting to detect genetic rearrangements in human cancer -- Mutation analysis of large genomic regions in tumor DNA using single-strand conformation polymorphism. Lessons from the ATM gene -- Mutational analysis of oncogenes and tumor suppressor genes in human cancer using denaturing gradient gel electrophoresis -- Detection of mutations in human cancer using nonisotopic RNase cleavage assay -- Mutational analysis of the neurofibromatosis type 1 gene in childhood myelodysplastic syndromes using a protein truncation assay -- Mutation analysis of cancer using automated sequencing -- Detection of differentially expressed genes in cancer using differential display -- Genomewide gene expression analysis using cDNA microarrays -- Gene expression profiling in cancer using cDNA microarrays -- Wilms tumor gene WT1 as a tumor marker for leukemic blast cells and its role in leukemogenesis -- Detection of aberrant methylation of the p15INK4B gene promoter -- Clonality studies in cancer based on X chromosome inactivation phenomenon -- Telomere length changes in human cancer -- Measurement of telomerase activity in human hematopoietic cells and neoplastic disorders
Control code
51480784
Dimensions
unknown
Extent
1 online resource (xi, 302 pages)
Form of item
online
Isbn
9780585438917
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1385/1592591353
Other physical details
illustrations (some color).
Reproduction note
Electronic reproduction.
Specific material designation
remote
System control number
(OCoLC)51480784
System details
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
Label
Molecular analysis of cancer, edited by Jacqueline Boultwood and Carrie Fidler
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Molecular analysis of cancer. An overview -- Detection of chromosome abnormalities in leukemia using fluorescence in situ hybridization -- Spectral karyotyping in cancer cytogenetics -- Comparative genomic hybridization analysis -- Detection of chromosomal deletions by microsatellite analysis -- Detection and quantification of leukemia-specific rearrangements -- Detection of t(2;5)(p23;q35) translocation by long-range PCR of genomic DNA -- Use of DNA fingerprinting to detect genetic rearrangements in human cancer -- Mutation analysis of large genomic regions in tumor DNA using single-strand conformation polymorphism. Lessons from the ATM gene -- Mutational analysis of oncogenes and tumor suppressor genes in human cancer using denaturing gradient gel electrophoresis -- Detection of mutations in human cancer using nonisotopic RNase cleavage assay -- Mutational analysis of the neurofibromatosis type 1 gene in childhood myelodysplastic syndromes using a protein truncation assay -- Mutation analysis of cancer using automated sequencing -- Detection of differentially expressed genes in cancer using differential display -- Genomewide gene expression analysis using cDNA microarrays -- Gene expression profiling in cancer using cDNA microarrays -- Wilms tumor gene WT1 as a tumor marker for leukemic blast cells and its role in leukemogenesis -- Detection of aberrant methylation of the p15INK4B gene promoter -- Clonality studies in cancer based on X chromosome inactivation phenomenon -- Telomere length changes in human cancer -- Measurement of telomerase activity in human hematopoietic cells and neoplastic disorders
Control code
51480784
Dimensions
unknown
Extent
1 online resource (xi, 302 pages)
Form of item
online
Isbn
9780585438917
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1385/1592591353
Other physical details
illustrations (some color).
Reproduction note
Electronic reproduction.
Specific material designation
remote
System control number
(OCoLC)51480784
System details
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.

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