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The Resource Molecular toxicology protocols, edited by Phouthone Keohavong, Stephen G. Grant

Molecular toxicology protocols, edited by Phouthone Keohavong, Stephen G. Grant

Label
Molecular toxicology protocols
Title
Molecular toxicology protocols
Statement of responsibility
edited by Phouthone Keohavong, Stephen G. Grant
Contributor
Subject
Genre
Language
eng
Summary
New state-of-the-art molecular techniques promise to transform the field of genetic toxicology by making it possible to directly detect genotoxic exposures and their consequences in humans, to identify the agent(s) involved, and to clinically manage the exposed population. In Molecular Toxicology Protocols, researchers from prominent universities and cancer centers around the world describe in detail their best techniques for analyzing genotoxic exposure and the resulting biological effects, including intermediate biomarkers such as DNA and chromosomal damage, mutations in reporter and oncogenes, and the earliest possible detection of cancer. The authors emphasize analytical methods specifically developed for use in human populations and in cancer patients, or in other in vivo systems such as transgenic mice. Among the applications detailed are the analysis of interactions of chemical and physical agents with cellular macromolecules, especially DNA, the assessment of medically relevant toxicity, and the individualized characterization of genetic damage and repair. There are also methods to assess and characterize the modulation of this damage and repair through individual differences in specific and genome-wide gene expression, including metabolic profiling and apoptotic capacity. These methods mark a shift in emphasis from studies of the agents themselves to the exposed population, and from studies of small populations with significant known exposures to a single agent, to studies of common diseases, such as breast cancer, caused by normal levels of generalized genotoxic exposure. The protocols follow the successful Methods in Molecular Biology series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and highly practical, Molecular Toxicology Protocols offers a gold-standard collection of cutting-edge techniques designed to investigate a broad range of exposures-endogenous, accidental, medical, environmental, and occupational-and their role in human carcinogenesis and other diseases of aging
Member of
Cataloging source
COO
Dewey number
615.9
Illustrations
illustrations
Index
index present
LC call number
RA1220.3
LC item number
.M66 2005
Literary form
non fiction
NAL call number
QH506
NAL item number
.M45 v. 291
Nature of contents
  • dictionaries
  • bibliography
NLM call number
  • W1
  • QU 58.5
NLM item number
  • ME9616J v.291 2005
  • M7185 2005
http://library.link/vocab/relatedWorkOrContributorName
  • Keohavong, Phouthone
  • Grant, Stephen G
Series statement
Methods in molecular biology
Series volume
291
http://library.link/vocab/subjectName
  • Molecular toxicology
  • Apoptosis
  • DNA Repair
  • DNA Adducts
  • DNA Mutational Analysis
  • MEDICAL
  • Molecular toxicology
Label
Molecular toxicology protocols, edited by Phouthone Keohavong, Stephen G. Grant
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Part I. Analysis of DNA adducts -- Part II. Detection of chromosomal and genome-wide damage -- Part III. Detection and characterization of surrogate gene mutation -- Part IV. Detection and characterization of cancer gene mutation -- Part V. Analysis of DNA repair mechanisms -- Part VI. Array technologies -- Part VII. Apoptosis
Control code
60949286
Dimensions
unknown
Extent
1 online resource (xiv, 489)
Form of item
online
Isbn
9781588290847
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations.
http://library.link/vocab/ext/overdrive/overdriveId
978-1-58829-084-7
Specific material designation
remote
System control number
(OCoLC)60949286
Label
Molecular toxicology protocols, edited by Phouthone Keohavong, Stephen G. Grant
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Part I. Analysis of DNA adducts -- Part II. Detection of chromosomal and genome-wide damage -- Part III. Detection and characterization of surrogate gene mutation -- Part IV. Detection and characterization of cancer gene mutation -- Part V. Analysis of DNA repair mechanisms -- Part VI. Array technologies -- Part VII. Apoptosis
Control code
60949286
Dimensions
unknown
Extent
1 online resource (xiv, 489)
Form of item
online
Isbn
9781588290847
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations.
http://library.link/vocab/ext/overdrive/overdriveId
978-1-58829-084-7
Specific material designation
remote
System control number
(OCoLC)60949286

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      38.944491 -92.326012
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