The Resource Neurobiology of Huntington's disease : applications to drug discovery, edited by Donald C. Lo and Robert E. Hughes, (electronic resource)

Neurobiology of Huntington's disease : applications to drug discovery, edited by Donald C. Lo and Robert E. Hughes, (electronic resource)

Label
Neurobiology of Huntington's disease : applications to drug discovery
Title
Neurobiology of Huntington's disease
Title remainder
applications to drug discovery
Statement of responsibility
edited by Donald C. Lo and Robert E. Hughes
Contributor
Subject
Language
eng
Summary
"Neurobiology of Huntington's Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this paradigmatic neurodegenerative disease. Drawing on the expertise of key researchers in the field, the book discusses the basic neurobiology of Huntington's disease and how its monogenic nature confers enormous practical advantages for translational research, including the creation of robust experimental tools, models, and assays to facilitate discovery and validation of molecular targets and drug candidates for HD. Written to support future basic research as well as drug development efforts, this volume: covers the latest research approaches in genetics, genomics, and proteomics, including high-throughput and high-content screening; highlights advances in the discovery and development of new drug therapies for neurodegenerative disorders; examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage While the development of effective drug treatments for Huntington's disease continues to be tremendously challenging, a highly interactive and cooperative community of researchers and clinical investigators now brings us to the threshold of potential breakthroughs in the quest for therapeutic agents. The impressive array of drug discovery resources outlined in the text holds much promise for treating this devastating disease, providing hope to long-suffering Huntington's disease patients and their families."--Publisher's description
Member of
Cataloging source
FlBoTFG
Dewey number
616.851
Illustrations
  • illustrations
  • plates
Index
index present
LC call number
RC394.H85
LC item number
N48 2010
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
WL 390
http://library.link/vocab/relatedWorkOrContributorName
  • Lo, Donald C
  • Hughes, Robert E.
Series statement
Frontiers in neuroscience
http://library.link/vocab/subjectName
  • Huntington Disease
  • Drug Discovery
  • Huntington Disease
Label
Neurobiology of Huntington's disease : applications to drug discovery, edited by Donald C. Lo and Robert E. Hughes, (electronic resource)
Instantiates
Publication
Note
Title from resource home page (NCBI Bookshelf, viewed August 18, 2011)
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Huntington's disease : clinical features and routes to therapy / Henry L. Paulson and Roger L. Albin -- Huntington's disease pathogenesis : mechanisms and pathways / Albert R. La Spada, Patrick Weydt, and Victor V. Pineda -- Protein interactions and target discovery in HD / John P. Miller and Robert E. Hughes -- Target validation for Huntington's disease / Seung P. Kwak, James K.T. Wang, and David S. Howland -- High-throughput and high-content screening for Huntington's disease therapeutics / Hemant Varma, Donald C. Lo, and Brent R. Stockwell -- Value of invertebrate genetics and biology to develop neuroprotective and preventive medicine in Huntington's disease / Christian Neri -- Mouse models for validating preclinical candidates for HD / X. William Yang and Michelle Gray -- Pharmaceutical development for HD / Richard J. Morse ... [et al.] -- RNA and DNA-based therapies for Huntington's disease / Meghan Sass and Neil Aronin -- Recombinant intrabodies as molecular tools and potential therapeutics for Huntington's disease / Ali Khoshnan ... [et al.] -- Biomarkers to enable the development of neuroprotective therapies for Huntington's disease / Steven M. Hersch and H. Diana Rosas -- Huntington disease : clinical experimental therapeutics / Ray Dorsey and Ira Shoulson
Control code
677994381
Extent
1 online resource
Form of item
online
Isbn
9781420008258
Isbn Type
(e-book : PDF)
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)677994381
Label
Neurobiology of Huntington's disease : applications to drug discovery, edited by Donald C. Lo and Robert E. Hughes, (electronic resource)
Publication
Note
Title from resource home page (NCBI Bookshelf, viewed August 18, 2011)
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Huntington's disease : clinical features and routes to therapy / Henry L. Paulson and Roger L. Albin -- Huntington's disease pathogenesis : mechanisms and pathways / Albert R. La Spada, Patrick Weydt, and Victor V. Pineda -- Protein interactions and target discovery in HD / John P. Miller and Robert E. Hughes -- Target validation for Huntington's disease / Seung P. Kwak, James K.T. Wang, and David S. Howland -- High-throughput and high-content screening for Huntington's disease therapeutics / Hemant Varma, Donald C. Lo, and Brent R. Stockwell -- Value of invertebrate genetics and biology to develop neuroprotective and preventive medicine in Huntington's disease / Christian Neri -- Mouse models for validating preclinical candidates for HD / X. William Yang and Michelle Gray -- Pharmaceutical development for HD / Richard J. Morse ... [et al.] -- RNA and DNA-based therapies for Huntington's disease / Meghan Sass and Neil Aronin -- Recombinant intrabodies as molecular tools and potential therapeutics for Huntington's disease / Ali Khoshnan ... [et al.] -- Biomarkers to enable the development of neuroprotective therapies for Huntington's disease / Steven M. Hersch and H. Diana Rosas -- Huntington disease : clinical experimental therapeutics / Ray Dorsey and Ira Shoulson
Control code
677994381
Extent
1 online resource
Form of item
online
Isbn
9781420008258
Isbn Type
(e-book : PDF)
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)677994381

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