The Resource Phage display peptides for breast cancer targeting, by Maura K. Bates, (electronic resource)

Phage display peptides for breast cancer targeting, by Maura K. Bates, (electronic resource)

Label
Phage display peptides for breast cancer targeting
Title
Phage display peptides for breast cancer targeting
Statement of responsibility
by Maura K. Bates
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
Cancer cell surfaces differ from healthy cell surfaces allowing the detection of cancer targets on the cell. Use of these targets combined with radiolabeled targeting vehicles results in sensitive imaging agents, with peptides identified as targeting vehicles. Human epidermal growth factor receptor 2 (ErbB-2) and galectin-3 (gal-3) are two targets for peptides, which have been shown to be over-expressed in a variety of tumors, including breast adenocarcinomas. ErbB-2 is involved in signal transduction pathways for cell growth and differentiation. Gal-3 is a lectin involved in carbohydrate-mediated cancer cell adhesion via contact with the tumor-specific Thomsen-Friedenreich (TF) disaccharide antigen, which increases metastasis from primary tumors. Bacteriophage (phage) display is a technique to select peptide sequences that bind to specific targets, such as ErbB-2 and gal-3. The target ErbB-2 was used to identify peptide KCCYSL. In this study, KCCYSL was radiolabeled by two different chelation chemistry methods and 99mTc to create two potential imaging agents. These radiolabeled peptides were analyzed both in vitro with breast cancer cell lines, and also in vivo performing biodistribution and breast tumor imaging studies in mouse models of breast cancer. Another target, gal-3, was used to identify peptide ANTPCGPYTHDCPVKR also using the phage display technique. In this study, to characterize the peptide and identify key residues for peptide interaction, in vitro cell binding and enzyme-linked immunosorbent assay experiments were done with alanine point mutation peptides
Cataloging source
MMU
http://library.link/vocab/creatorDate
1985-
http://library.link/vocab/creatorName
Bates, Maura K.
Degree
M.S.
Dissertation year
2010.
Granting institution
University of Missouri-Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
NLM call number
WP 870
http://library.link/vocab/relatedWorkOrContributorName
Deutscher, Susan L.
http://library.link/vocab/subjectName
  • Breast Neoplasms
  • Peptide Library
  • Breast Neoplasms
  • Galectin 3
  • Peptides
  • Peptides
  • Receptor, ErbB-2
  • Technetium
Target audience
specialized
Label
Phage display peptides for breast cancer targeting, by Maura K. Bates, (electronic resource)
Instantiates
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from PDF of title page (University of Missouri--Columbia, viewed on April 15, 2011)
  • Vita
  • Thesis advisor: Susan L. Deutscher
  • "December 2010"
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
712789148
Extent
1 online resource (viii, 60 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)712789148
Label
Phage display peptides for breast cancer targeting, by Maura K. Bates, (electronic resource)
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from PDF of title page (University of Missouri--Columbia, viewed on April 15, 2011)
  • Vita
  • Thesis advisor: Susan L. Deutscher
  • "December 2010"
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
712789148
Extent
1 online resource (viii, 60 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)712789148

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