The Resource Pupillary light reflex in children with autism spectrum disorders, by Chathuri Daluwatte

Pupillary light reflex in children with autism spectrum disorders, by Chathuri Daluwatte

Label
Pupillary light reflex in children with autism spectrum disorders
Title
Pupillary light reflex in children with autism spectrum disorders
Statement of responsibility
by Chathuri Daluwatte
Creator
Contributor
Author
Thesis advisor
Subject
Genre
Language
eng
Summary
Pupillary light reflex (PLR) refers to the phenomenon of pupil size changing with respect to retinal illumination. It's a noninvasive, functional test which can reveal a rich set of information about nervous system. Abnormal PLR in children with autism spectrum disorders (ASD) was previously reported in a small population. In this research, a series of systematic studies were carried out to investigate the association of atypical PLR with ASD in a large population. An experimental protocol was developed to measure PLR simultaneously with heart rate variability (HRV), a commonly used autonomic nervous system (ANS) measure. Our results indicate that variations of PLR and HRV are not associated in typically developing children. However, significant age effects on both PLR and HRV were observed in this population. In typically developing children, the resting pupil diameter increased with age significantly up to age 12. PLR constriction increased with age in children younger than 8 years old and reached a plateau thereafter. PLR latency decreased significantly from 6 to 9 years and stabilized thereafter. The average heart rate (AHR) decreased with age in typically developing children. Standard deviation of normal-to-normal intervals (SDNN) showed little change before 12 years of age but was increased in older children. High frequency normalized power (HFN) decreased with age in typically developing (TD) group. PLR and HRV were also measured in 152 children with ASD and 36 children with non-ASD neurodevelopmental disorders (NDDs). The results showed atypical PLR in the ASD group including longer PLR latency, reduced relative constriction amplitude, and shorter constriction/redilation time. Similar atypical PLR parameters were observed in the NDD group. The ASD and NDD groups had faster AHR than the TD group. The NDD group also showed a significantly faster AHR than the ASD group. The age effect on PLR latency which was observed in typically developing children of 6-9 years old was not observed in the ASD and NDD groups. However, the age effect on HRV in the ASD group was similar to the age effect which was observed in the TD group. PLR constriction amplitude showed a significant negative correlation with average heart rate in children with ASD, but not in typically developing children. ANS is also involved in regulating sensory behavior which is commonly atypical in children with ASD. We investigated potential association between PLR and sensory behaviors (behavioral observations) in children with ASD. The results indicated a weak but significant correlation between PLR constriction amplitude and sensory total score in the ASD group, but such correlation was not observed in typically developing children. This study produced solid evidence that PLR pathway is affected in ASD. The reduced PLR constriction amplitude in children with ASD is associated with ANS dysfunction. Our results also suggest that PLR may be used as simple tool for monitoring developmental trajectory in children
Cataloging source
MUU
http://library.link/vocab/creatorDate
1983-
http://library.link/vocab/creatorName
Daluwatte, Chathuri
Degree
Ph.D.
Dissertation note
Dissertation
Dissertation year
2013.
Government publication
government publication of a state province territory dependency etc
Granting institution
University of Missouri--Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
Yao, Gang
http://library.link/vocab/subjectName
  • Autism spectrum disorders in children
  • Pupil (Eye)
  • Eye
  • Reflection (Optics)
Label
Pupillary light reflex in children with autism spectrum disorders, by Chathuri Daluwatte
Instantiates
Publication
Note
  • "A Dissertation presented to the Faculty of the Graduate School at the University of Missouri--Columbia In Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy."
  • Dissertation supervisor: Dr. Gang Yao
  • Vita
Bibliography note
Includes bibliographical references (pages 123-138)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent.
Control code
891216460
Extent
1 online resource (xiii, 139 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
  • c
Other physical details
illustrations (some color)
Specific material designation
remote
System control number
(OCoLC)891216460
Label
Pupillary light reflex in children with autism spectrum disorders, by Chathuri Daluwatte
Publication
Note
  • "A Dissertation presented to the Faculty of the Graduate School at the University of Missouri--Columbia In Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy."
  • Dissertation supervisor: Dr. Gang Yao
  • Vita
Bibliography note
Includes bibliographical references (pages 123-138)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent.
Control code
891216460
Extent
1 online resource (xiii, 139 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
  • c
Other physical details
illustrations (some color)
Specific material designation
remote
System control number
(OCoLC)891216460

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