The Resource Regulation of Pcl6 and Pcl7 in a Glc7 pathway in Saccharomyces cerevisiae, by Anthea Anita Aikins, (electronic resource)

Regulation of Pcl6 and Pcl7 in a Glc7 pathway in Saccharomyces cerevisiae, by Anthea Anita Aikins, (electronic resource)

Label
Regulation of Pcl6 and Pcl7 in a Glc7 pathway in Saccharomyces cerevisiae
Title
Regulation of Pcl6 and Pcl7 in a Glc7 pathway in Saccharomyces cerevisiae
Statement of responsibility
by Anthea Anita Aikins
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
GLC7 is an essential gene in Saccharomyces cerevisiae that encodes the catalytic subunit of protein phosphatase-1. Glc7 is conditionally activated by phospho-Glc8, which is phosphorylated by the cyclin dependent kinase, Pho85, associated with Pcl6 and Pcl7 (two of its ten cyclins). Our goal was to determine the input(s) that regulate Pcl6 and Pcl7. This will provide us with valuable information about the conditional activation of Glc7 by phospho-Glc8. We determined Pcl6 to be more stable than Pcl7. We confirmed and discovered that Elongin C (Elc1) stabilizes both Pcl6 and Pcl7. A null mutation of elc1 compromises the in vivo function of Pcl6 and Pcl7 in cell growth and in DNA damage response to 4-nitroquinoline oxide (4-NQO). Elc1 is found in two nucleotide excision repair complexes (NEF4 and Ela1 containing complex). We hypothesized that, Pcl6 and Pcl7 levels are induced by DNA damage and controlled by the Elc1 containing complexes. We discovered that the NEF4 and a non-Elc1 containing complex, NEF2, control the stability of both cyclins. Additionally, DNA damage is an input that controls the conditional activation of Glc7 by phospho-Glc8
Cataloging source
MMU
http://library.link/vocab/creatorDate
1982-
http://library.link/vocab/creatorName
Aikins, Anthea Anita
Degree
Ph. D.
Dissertation year
2010.
Granting institution
University of Missouri-Columbia
Illustrations
illustrations
Index
no index present
LC call number
QK623.S23
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
NLM call number
QW 180.5.A8
http://library.link/vocab/relatedWorkOrContributorDate
1956-
http://library.link/vocab/relatedWorkOrContributorName
Cannon, John Francis
http://library.link/vocab/subjectName
  • Saccharomyces cerevisiae
  • Saccharomyces cerevisiae
  • Cyclins
  • Cyclins
  • DNA Damage
  • DNA Repair
  • Protein Phosphatase 1
  • Protein Phosphatase 1
  • Saccharomyces cerevisiae Proteins
  • Saccharomyces cerevisiae Proteins
Target audience
specialized
Label
Regulation of Pcl6 and Pcl7 in a Glc7 pathway in Saccharomyces cerevisiae, by Anthea Anita Aikins, (electronic resource)
Instantiates
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from PDF of title page (University of Missouri--Columbia, viewed on March 11, 2011)
  • Vita
  • Thesis advisor: John F. Cannon
  • "December 2010"
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
706826985
Extent
1 online resource (xiv, 124 pages)
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)706826985
Label
Regulation of Pcl6 and Pcl7 in a Glc7 pathway in Saccharomyces cerevisiae, by Anthea Anita Aikins, (electronic resource)
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from PDF of title page (University of Missouri--Columbia, viewed on March 11, 2011)
  • Vita
  • Thesis advisor: John F. Cannon
  • "December 2010"
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
706826985
Extent
1 online resource (xiv, 124 pages)
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)706826985

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