The Resource Screening for hepatocellular cancer in chronic liver disease : a systematic review, prepared for Department of Veterans Affairs, Veterans Health Administration, Health Services Research & Development Service, Washington, DC ; prepared by Evidence-based Synthesis Program (ESP) Center, Portland VA Medical Center, Portland, OR.principal investigators, Devan Kansagara, Janice H. Jou ; co-investigators, Joel Papak, Amirala S. Pasha, Maya O'Neil, Michele Freeman, Rose Relevo, Ana Quinones, Makalapua Motu'apuaka

Screening for hepatocellular cancer in chronic liver disease : a systematic review, prepared for Department of Veterans Affairs, Veterans Health Administration, Health Services Research & Development Service, Washington, DC ; prepared by Evidence-based Synthesis Program (ESP) Center, Portland VA Medical Center, Portland, OR.principal investigators, Devan Kansagara, Janice H. Jou ; co-investigators, Joel Papak, Amirala S. Pasha, Maya O'Neil, Michele Freeman, Rose Relevo, Ana Quinones, Makalapua Motu'apuaka

Label
Screening for hepatocellular cancer in chronic liver disease : a systematic review
Title
Screening for hepatocellular cancer in chronic liver disease
Title remainder
a systematic review
Statement of responsibility
prepared for Department of Veterans Affairs, Veterans Health Administration, Health Services Research & Development Service, Washington, DC ; prepared by Evidence-based Synthesis Program (ESP) Center, Portland VA Medical Center, Portland, OR.principal investigators, Devan Kansagara, Janice H. Jou ; co-investigators, Joel Papak, Amirala S. Pasha, Maya O'Neil, Michele Freeman, Rose Relevo, Ana Quinones, Makalapua Motu'apuaka
Creator
Contributor
Author
Issuing body
Subject
Genre
Language
eng
Summary
In the Veterans Health Administration (VHA), there has been a marked increase in the prevalence of cirrhosis from chronic hepatitis C infection with a corresponding increase in the number of hepatocellular cancer (HCC) diagnoses. From 1996 to 2006, the prevalence of cirrhosis among Veterans with chronic hepatitis C infection rose from 9 to 18.5%, and the prevalence of HCC rose from 0.07 to 1.3%. In the general population, the incidence of HCC rose between 1992 and 2005 from 3.1/100,000 to 5.1/100,000, with localized tumors accounting for most of the increase. While, on average, the 5-year survival of HCC is low (13 to 16.5%), the survival of early-stage disease has risen. The rationale for screening is that imaging tests such as ultrasound can identify patients with early stage HCC and there are several potentially curative treatment options for patients with early stage HCC including liver transplantation, radiofrequency ablation, and liver resection. Several professional society guidelines currently recommend HCC screening using imaging studies and tumor markers mainly in patients with chronic hepatitis B or liver cirrhosis. However, recommendations for HCC screening remain controversial in part because of concerns over the quality and paucity of existing evidence, and because there have been concerns raised about overdiagnosis and patient harms in other cancer screening programs. We conducted a systematic review of the published literature to better understand the incremental benefits and harms of routine HCC screening in patients with chronic liver disease compared to clinical or incidental diagnosis. We looked for direct evidence of the health outcome effects of screening. We also looked for indirect evidence of the effects of screening by evaluating studies examining the health outcome benefits and harms of treating early-stage HCC which, because the intent and result of routine screening is detection of early-stage disease, is a proxy for screen-detected disease
Member of
Cataloging source
NLM
http://library.link/vocab/creatorName
Kansagara, Devan
Government publication
federal national government publication
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
WI 735
http://library.link/vocab/relatedWorkOrContributorName
  • Jou, Janice H.
  • United States
  • Portland VA Medical Center
  • Quality Enhancement Research Initiative (U.S.)
Series statement
Evidence-based synthesis program
http://library.link/vocab/subjectName
  • Liver Neoplasms
  • Early Detection of Cancer
  • Hepatitis, Chronic
  • Liver Cirrhosis
Label
Screening for hepatocellular cancer in chronic liver disease : a systematic review, prepared for Department of Veterans Affairs, Veterans Health Administration, Health Services Research & Development Service, Washington, DC ; prepared by Evidence-based Synthesis Program (ESP) Center, Portland VA Medical Center, Portland, OR.principal investigators, Devan Kansagara, Janice H. Jou ; co-investigators, Joel Papak, Amirala S. Pasha, Maya O'Neil, Michele Freeman, Rose Relevo, Ana Quinones, Makalapua Motu'apuaka
Instantiates
Publication
Note
  • "January 2014."
  • "VA-ESP Project #05-225."
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
  • text
  • still image
Content type code
  • txt
  • sti
Content type MARC source
  • rdacontent
  • rdacontent
Control code
898325894
Extent
1 online resource (iii, 61 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations.
Specific material designation
remote
System control number
(OCoLC)898325894
Label
Screening for hepatocellular cancer in chronic liver disease : a systematic review, prepared for Department of Veterans Affairs, Veterans Health Administration, Health Services Research & Development Service, Washington, DC ; prepared by Evidence-based Synthesis Program (ESP) Center, Portland VA Medical Center, Portland, OR.principal investigators, Devan Kansagara, Janice H. Jou ; co-investigators, Joel Papak, Amirala S. Pasha, Maya O'Neil, Michele Freeman, Rose Relevo, Ana Quinones, Makalapua Motu'apuaka
Publication
Note
  • "January 2014."
  • "VA-ESP Project #05-225."
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
  • text
  • still image
Content type code
  • txt
  • sti
Content type MARC source
  • rdacontent
  • rdacontent
Control code
898325894
Extent
1 online resource (iii, 61 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations.
Specific material designation
remote
System control number
(OCoLC)898325894

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