The Resource Secretory phospholipase A2-IIA in Alzheimer's disease and inflammatory responses in astrocytes, by Michael D. Jensen, (electronic resource)

Secretory phospholipase A2-IIA in Alzheimer's disease and inflammatory responses in astrocytes, by Michael D. Jensen, (electronic resource)

Label
Secretory phospholipase A2-IIA in Alzheimer's disease and inflammatory responses in astrocytes
Title
Secretory phospholipase A2-IIA in Alzheimer's disease and inflammatory responses in astrocytes
Statement of responsibility
by Michael D. Jensen
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
Alzheimer's disease (AD) is a progressive, fatal neurodegenerative disease marked with dementia. Secretory phospholipase A2-IIA (sPLA2-IIA) is an inflammatory protein known to have a role in the pathogenesis of multiple inflammatory diseases and is implicated in several neurodegenerative diseases. In AD, astrocytes become reactive and have increased expression of inflammatory cytokines such as IL-1[beta] and TNF-[alpha], and undergo increased oxidative stress. In these studies, we show that sPLA2-IIA mRNA is up-regulated in AD brains (compared to non-demented elderly brains). To further elucidate involvement of oxidative pathways in induction of sPLA2-IIA mRNA and protein by pro-inflammatory cytokines, we performed in vitro studies with immortalized astrocytes (DITNC) and various inhibitors and antioxidants. The results of these studies suggest the involvement of oxidative pathways, possibly the NADPH oxidase pathway. These results, taken together, identify sPLA2-IIA as an inflammatory factor for Alzheimer's disease, and support the involvement of NADPH oxidase in the cytokine induction of sPLA2-IIA in astrocytes and the possibility of using botanical antioxidants to ameliorate the inflammatory response in these cells
Cataloging source
MMU
http://library.link/vocab/creatorDate
1979-
http://library.link/vocab/creatorName
Jensen, Michael D.
Degree
Ph. D.
Dissertation year
2009.
Granting institution
University of Missouri-Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
Sun, Grace Y.
http://library.link/vocab/subjectName
  • Alzheimer's disease
  • Phospholipase A2
  • Enzymology
  • Astrocytes
  • NAD (Coenzyme)
  • Phosphates
  • Oxidases
  • Active oxygen in the body
  • Inflammation
  • Alzheimer Disease
  • Group II Phospholipases A2
  • Alzheimer Disease
  • Astrocytes
  • Inflammation
  • NADPH Oxidases
Target audience
specialized
Label
Secretory phospholipase A2-IIA in Alzheimer's disease and inflammatory responses in astrocytes, by Michael D. Jensen, (electronic resource)
Instantiates
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from PDF of title page (University of Missouri--Columbia, viewed on March 25, 2010)
  • Vita
  • Thesis advisor: Grace Y. Sun
  • "December 2009"
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
570609482
Extent
1 online resource (xi, 122 pages)
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations
Specific material designation
remote
System control number
(OCoLC)570609482
Label
Secretory phospholipase A2-IIA in Alzheimer's disease and inflammatory responses in astrocytes, by Michael D. Jensen, (electronic resource)
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from PDF of title page (University of Missouri--Columbia, viewed on March 25, 2010)
  • Vita
  • Thesis advisor: Grace Y. Sun
  • "December 2009"
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
570609482
Extent
1 online resource (xi, 122 pages)
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations
Specific material designation
remote
System control number
(OCoLC)570609482

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