Borrow it
Coverart for item
The Resource Sequential experimentation in clinical trials : design and analysis, Jay Bartroff, Tze Leung Lai, Mei-Chiung Shih

Sequential experimentation in clinical trials : design and analysis, Jay Bartroff, Tze Leung Lai, Mei-Chiung Shih

Creator
Contributor
Summary
This book presents an integrated methodology for sequential experimentation in clinical trials. The methodology allows sequential learning during the course of a trial to improve the efficiency of the trial design, which often lacks adequate information at the planning stage. Adaptation via sequential learning of unknown parameters is a central idea not only in adaptive designs of confirmatory clinical trials but also in the theory of optimal nonlinear experimental design, which the book covers as introductory material. Other introductory topics for which the book provides preparatory background include sequential testing theory, dynamic programming and stochastic optimization, survival analysis and resampling methods. In this way, the book gives a self-contained and thorough treatment of group sequential and adaptive designs, time-sequential trials with failure-time endpoints, and statistical inference at the conclusion of these trials. The book can be used for graduate courses in sequential analysis, clinical trials, and biostatistics, and also for short courses on clinical trials at professional meetings. Each chapter ends with supplements for the reader to explore related concepts and methods, and problems which can be used for exercises in graduate courses. Jay Bartroff is Associate Professor of Mathematics at the University of Southern California where he is a member of the Laboratory of Applied Pharmacokinetics at the USC Keck School of Medicine. He is a leading expert on group sequential and multistage adaptive statistical procedures and their applications to clinical trial designs, and he is a sought-after consultant in academia and industry. Tze Leung Lai is Professor of Statistics, and by courtesy, of Health Research and Policy and of the Institute of Computational and Mathematical Engineering at Stanford University, where he is the Director of the Financial and Risk Modeling Institute and Co-director of the Biostatistics Core at the Stanford Cancer Institute and of the Center for Innovative Study Design at the School of Medicine. He made seminal contributions to sequential analysis, innovative clinical trial designs, adaptive methods, survival analysis, nonlinear and generalized mixed models, hybrid resampling methods, and received the Committee of Presidents of Statistical Societies (COPSS) Award in 1983. Mei-Chiung Shih is Assistant Professor of Biostatistics and a member of the Stanford Cancer Institute and of the Center for Innovative Study Design at the School of Medicine at Stanford University. She is also Associate Director for Scientific and Technical Operations at the Department of Veterans Affairs (VA) Cooperative Studies Program Coordinating Center at Palo Alto Health Care System. She is a leading expert on group sequential and adaptive designs and inference of clinical trials, longitudinal and survival data analysis, and has been leading the design, conduct and analysis of several large trials at the VA
Language
eng
Work
Publication
Extent
1 online resource.
Contents
  • Introduction
  • Nonlinear Regression, Experimental Design, and Phase I Clinical Trials
  • Sequential Testing Theory and Stochastic Optimization Over Time
  • Group Sequential Design of Phase II and III Trials
  • Sequential Methods for Vaccine Safety Evaluation and Surveillance in Public Health
  • Time-Sequential Design of Clinical Trials with Failure-Time Endpoints
  • Confidence Intervals and p-Values
  • Adaptive Design of Confirmatory Trials
Isbn
9781461461142
Instance
Label
Sequential experimentation in clinical trials : design and analysis
Title
Sequential experimentation in clinical trials
Title remainder
design and analysis
Statement of responsibility
Jay Bartroff, Tze Leung Lai, Mei-Chiung Shih
Creator
Contributor
Subject
Language
eng
Summary
This book presents an integrated methodology for sequential experimentation in clinical trials. The methodology allows sequential learning during the course of a trial to improve the efficiency of the trial design, which often lacks adequate information at the planning stage. Adaptation via sequential learning of unknown parameters is a central idea not only in adaptive designs of confirmatory clinical trials but also in the theory of optimal nonlinear experimental design, which the book covers as introductory material. Other introductory topics for which the book provides preparatory background include sequential testing theory, dynamic programming and stochastic optimization, survival analysis and resampling methods. In this way, the book gives a self-contained and thorough treatment of group sequential and adaptive designs, time-sequential trials with failure-time endpoints, and statistical inference at the conclusion of these trials. The book can be used for graduate courses in sequential analysis, clinical trials, and biostatistics, and also for short courses on clinical trials at professional meetings. Each chapter ends with supplements for the reader to explore related concepts and methods, and problems which can be used for exercises in graduate courses. Jay Bartroff is Associate Professor of Mathematics at the University of Southern California where he is a member of the Laboratory of Applied Pharmacokinetics at the USC Keck School of Medicine. He is a leading expert on group sequential and multistage adaptive statistical procedures and their applications to clinical trial designs, and he is a sought-after consultant in academia and industry. Tze Leung Lai is Professor of Statistics, and by courtesy, of Health Research and Policy and of the Institute of Computational and Mathematical Engineering at Stanford University, where he is the Director of the Financial and Risk Modeling Institute and Co-director of the Biostatistics Core at the Stanford Cancer Institute and of the Center for Innovative Study Design at the School of Medicine. He made seminal contributions to sequential analysis, innovative clinical trial designs, adaptive methods, survival analysis, nonlinear and generalized mixed models, hybrid resampling methods, and received the Committee of Presidents of Statistical Societies (COPSS) Award in 1983. Mei-Chiung Shih is Assistant Professor of Biostatistics and a member of the Stanford Cancer Institute and of the Center for Innovative Study Design at the School of Medicine at Stanford University. She is also Associate Director for Scientific and Technical Operations at the Department of Veterans Affairs (VA) Cooperative Studies Program Coordinating Center at Palo Alto Health Care System. She is a leading expert on group sequential and adaptive designs and inference of clinical trials, longitudinal and survival data analysis, and has been leading the design, conduct and analysis of several large trials at the VA
Member of
Cataloging source
GW5XE
http://library.link/vocab/creatorName
Bartroff, Jay
Dewey number
615.5072/4
Index
index present
LC call number
R853.S7
LC item number
B37 2013
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
WA 950
http://library.link/vocab/relatedWorkOrContributorName
  • Lai, T. L
  • Shih, Mei-Chiung
Series statement
Springer series in statistics,
Series volume
298
http://library.link/vocab/subjectName
  • Clinical trials
  • Sequential analysis
  • Clinical Trials as Topic
  • Statistics as Topic
  • BODY, MIND & SPIRIT
  • HEALTH & FITNESS
  • HEALTH & FITNESS
  • MEDICAL
  • Clinical trials
  • Sequential analysis
Label
Sequential experimentation in clinical trials : design and analysis, Jay Bartroff, Tze Leung Lai, Mei-Chiung Shih
Instantiates
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Introduction
  • Nonlinear Regression, Experimental Design, and Phase I Clinical Trials
  • Sequential Testing Theory and Stochastic Optimization Over Time
  • Group Sequential Design of Phase II and III Trials
  • Sequential Methods for Vaccine Safety Evaluation and Surveillance in Public Health
  • Time-Sequential Design of Clinical Trials with Failure-Time Endpoints
  • Confidence Intervals and p-Values
  • Adaptive Design of Confirmatory Trials
Control code
823304775
Dimensions
unknown
Extent
1 online resource.
File format
unknown
Form of item
online
Isbn
9781461461142
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-1-4614-6114-2
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)823304775
Label
Sequential experimentation in clinical trials : design and analysis, Jay Bartroff, Tze Leung Lai, Mei-Chiung Shih
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Introduction
  • Nonlinear Regression, Experimental Design, and Phase I Clinical Trials
  • Sequential Testing Theory and Stochastic Optimization Over Time
  • Group Sequential Design of Phase II and III Trials
  • Sequential Methods for Vaccine Safety Evaluation and Surveillance in Public Health
  • Time-Sequential Design of Clinical Trials with Failure-Time Endpoints
  • Confidence Intervals and p-Values
  • Adaptive Design of Confirmatory Trials
Control code
823304775
Dimensions
unknown
Extent
1 online resource.
File format
unknown
Form of item
online
Isbn
9781461461142
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-1-4614-6114-2
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)823304775

Subject

Member of

Library Locations

    • Ellis LibraryBorrow it
      1020 Lowry Street, Columbia, MO, 65201, US
      38.944491 -92.326012

Library Links

Structured data from the Bibframe namespace is licensed under the Creative Commons Attribution 4.0 International License by University of Missouri Libraries. Additional terms may apply to data associated with third party namespaces.
Processing Feedback ...