Coverart for item
The Resource Structural genomics and drug discovery : methods and protocols, edited by Wayne F. Anderson

Structural genomics and drug discovery : methods and protocols, edited by Wayne F. Anderson

Label
Structural genomics and drug discovery : methods and protocols
Title
Structural genomics and drug discovery
Title remainder
methods and protocols
Statement of responsibility
edited by Wayne F. Anderson
Contributor
Copyright holder
Editor
Subject
Genre
Language
eng
Summary
Structural Genomics and Drug Discovery: Methods and Protocols focuses on high throughput structure determination methods and how they can be applied to lay the groundwork for structure aided drug discovery. The methods and protocols that are described can be applied in any laboratory interested in using detailed structural information to advance the initial stages of drug discovery. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Structural Genomics and Drug Discovery: Methods and Protocols seeks to aid scientists in the further study into structural genomics approach as an efficient initial step toward drug discovery and the methods described will be useful to anyone interested in moving in this direction
Member of
Biography type
contains biographical information
Cataloging source
UKMGB
Dewey number
576.5
Illustrations
illustrations
Index
index present
LC call number
QH447
LC item number
.S77 2014
Literary form
non fiction
Nature of contents
bibliography
http://library.link/vocab/relatedWorkOrContributorName
  • Anderson, Wayne F.
  • Springer Science+Business Media
Series statement
  • Methods in molecular biology,
  • Springer protocols,
Series volume
1140
http://library.link/vocab/subjectName
  • Genomics
  • Drug development
  • Drug Discovery
  • Genomics
  • High-Throughput Screening Assays
Label
Structural genomics and drug discovery : methods and protocols, edited by Wayne F. Anderson
Instantiates
Publication
Copyright
Bibliography note
Includes bibliographical references and index
Carrier category
volume
Carrier category code
  • nc
Carrier MARC source
rdacarrier.
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent.
Contents
Data Management in the Modern Structural Biology and Biomedical Research Environment -- Structural Genomics of Human Proteins -- Target Selection for Structural Genomics of Infectious Diseases -- Selecting Targets from Eukaryotic Parasites for Structural Genomics and Drug Discovery -- High Throughput Cloning for Biophysical Applications -- Expression and Solubility Testing in a High Throughput Environment -- Protein Production for Structural Genomics Using E. coli Expression -- Eukaryotic Expression Systems for Structural Studies -- Automated Cell-free Protein Production Methods for Structural Studies -- Parallel Protein Purification -- Oxidative Refolding from Inclusion Bodies -- High throughput Crystallization Screening -- Screening Proteins for NMR Suitability -- Salvage or Recovery of Failed Targets by in situ Proteolysis -- Salvage of Failed Protein Targets by Reductive Alkylation -- Salvage or Recovery of Failed Targets by Mutagenesis to Reduce Surface Entropy -- Data Collection for Crystallographic Structure Determination -- Structure, Determination, Refinement, and Validation -- Virtual High-Throughput Ligand Screening -- Ligand Screening using Fluorescence Thermal Shift Analysis (FTS) -- Ligand Screening using Enzymatic Assays -- Ligand Screening using NMR -- Screening Ligands by X-ray Crystallography -- Case Study Structural Genomics and Human Protein Kinases
Control code
871305993
Dimensions
27 cm
Extent
xv, 344 pages
Isbn
9781493903535
Lccn
2014931091
Media category
unmediated
Media MARC source
rdamedia.
Media type code
  • n
Other physical details
illustrations (some color)
System control number
(OCoLC)871305993
Terms governing use
Current copyright fee: GBP18.72
Label
Structural genomics and drug discovery : methods and protocols, edited by Wayne F. Anderson
Publication
Copyright
Bibliography note
Includes bibliographical references and index
Carrier category
volume
Carrier category code
  • nc
Carrier MARC source
rdacarrier.
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent.
Contents
Data Management in the Modern Structural Biology and Biomedical Research Environment -- Structural Genomics of Human Proteins -- Target Selection for Structural Genomics of Infectious Diseases -- Selecting Targets from Eukaryotic Parasites for Structural Genomics and Drug Discovery -- High Throughput Cloning for Biophysical Applications -- Expression and Solubility Testing in a High Throughput Environment -- Protein Production for Structural Genomics Using E. coli Expression -- Eukaryotic Expression Systems for Structural Studies -- Automated Cell-free Protein Production Methods for Structural Studies -- Parallel Protein Purification -- Oxidative Refolding from Inclusion Bodies -- High throughput Crystallization Screening -- Screening Proteins for NMR Suitability -- Salvage or Recovery of Failed Targets by in situ Proteolysis -- Salvage of Failed Protein Targets by Reductive Alkylation -- Salvage or Recovery of Failed Targets by Mutagenesis to Reduce Surface Entropy -- Data Collection for Crystallographic Structure Determination -- Structure, Determination, Refinement, and Validation -- Virtual High-Throughput Ligand Screening -- Ligand Screening using Fluorescence Thermal Shift Analysis (FTS) -- Ligand Screening using Enzymatic Assays -- Ligand Screening using NMR -- Screening Ligands by X-ray Crystallography -- Case Study Structural Genomics and Human Protein Kinases
Control code
871305993
Dimensions
27 cm
Extent
xv, 344 pages
Isbn
9781493903535
Lccn
2014931091
Media category
unmediated
Media MARC source
rdamedia.
Media type code
  • n
Other physical details
illustrations (some color)
System control number
(OCoLC)871305993
Terms governing use
Current copyright fee: GBP18.72

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