The Resource Tavocept (BNP7787) : a novel chemoprotector/sensitizer and radioprotector/sensitizer, by David Bommarito, (electronic resource)

Tavocept (BNP7787) : a novel chemoprotector/sensitizer and radioprotector/sensitizer, by David Bommarito, (electronic resource)

Label
Tavocept (BNP7787) : a novel chemoprotector/sensitizer and radioprotector/sensitizer
Title
Tavocept (BNP7787)
Title remainder
a novel chemoprotector/sensitizer and radioprotector/sensitizer
Statement of responsibility
by David Bommarito
Creator
Subject
Genre
Language
eng
Summary
Introduction: Tavocept is a novel chemoprotector/ sensitizer that has been used in combination with cisplatin to treat adenocarcinomas. The objectives of this study were to evaluate the interaction of radiation and Tavocept on a nasal tumor cell line and try to apply the concepts to the treatment canine nasal tumors. Materials and Methods: Using cell culture techniques and the nasal carcinoma cell line RPMI 2650, various combinations of radiation, cisplatin chemotherapy, and Tavocept were evaluated. Cytotoxicity to the cells was established using the sulfarhodamine (SRB) dye assay. Results: Tavocept alone did not show any cytotoxicity or increased cell growth compared to the control group. The addition of Tavocept increased the cytotoxicity of cisplatin compared to cisplatin alone. The combination of Tavocept to radiation therapy appeared no different than radiation alone. The addition of Tavocept at a low and high concentration to radiation and cisplatin increased cytotoxicity compared to radiation and cisplatin alone. Conclusions: Tavocept by itself appears to not have any toxic effects on the cell line, but it increases the cytotoxicity of cisplatin suggesting chemosensitization. There was no apparent interaction with radiation, neither sensitization nor protection
Cataloging source
MMU
http://library.link/vocab/creatorName
Bommarito, David
Degree
M.S.
Dissertation year
2011.
Granting institution
University of Missouri-Columbia
Illustrations
illustrations
Index
no index present
LC call number
RC280.N6
Literary form
non fiction
Nature of contents
  • dictionaries
  • theses
  • bibliography
NLM call number
WV 300
http://library.link/vocab/subjectName
  • Adenocarcinoma
  • Adenocarcinoma
  • Nose
  • Antineoplastic agents
  • Cisplatin
  • Mesna
  • Adenocarcinoma
  • Adenocarcinoma
  • Cisplatin
  • Nose Neoplasms
  • Nose Neoplasms
Label
Tavocept (BNP7787) : a novel chemoprotector/sensitizer and radioprotector/sensitizer, by David Bommarito, (electronic resource)
Instantiates
Publication
Contributor
Thesis advisor
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Thesis advisor: Carolyn Henry
  • "May 2011"
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
809700908
Extent
1 online resource (vi, 73 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)809700908
Label
Tavocept (BNP7787) : a novel chemoprotector/sensitizer and radioprotector/sensitizer, by David Bommarito, (electronic resource)
Publication
Contributor
Thesis advisor
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Thesis advisor: Carolyn Henry
  • "May 2011"
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
809700908
Extent
1 online resource (vi, 73 pages)
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)809700908

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