The Resource The effects of the selective estrogen receptor modulators MPP and raloxifene in normal and cancerous human and murine uterine tissue, by Angela Marie Davis, (electronic resource)

The effects of the selective estrogen receptor modulators MPP and raloxifene in normal and cancerous human and murine uterine tissue, by Angela Marie Davis, (electronic resource)

Label
The effects of the selective estrogen receptor modulators MPP and raloxifene in normal and cancerous human and murine uterine tissue
Title
The effects of the selective estrogen receptor modulators MPP and raloxifene in normal and cancerous human and murine uterine tissue
Statement of responsibility
by Angela Marie Davis
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
The goal of this research was to determine the in vitro and in vivo effects of the Selective Estrogen Receptor Modulators (SERMs), methyl-piperidino-pyrazole (MPP), raloxifene, ICI 182,780 and 17[beta]-estradiol on endometrial carcinoma cells in culture and on murine uterine tissue. These SERMs have been developed to target and understand the role of estrogen receptor action in estrogen-responsive organs. Based on their antagonistic actions, SERMs have both real and potential value in treating estrogen-responsive cancers, including endometrial cancer. The studies described herein verify that the SERMs MPP and raloxifene demonstrate partial agonistic effects in ovariectomized wild-type and ER-[beta] knockout (ER[beta]KO) mice but also induce apoptosis and proliferation in vitro in cultured endometrial cell lines, Ishikawa and RL-95. Thus, MPP and raloxifene exert apparently contrasting in vitro and in vivo effects due to their mixed agonist/antagonist action on murine uterine estrogen receptor in vivo. In addition to these data, I report gene expression changes in the uterus of mice treated individually or with the combination of 17[beta]-estradiol and the SERMs, MPP, raloxifene, ICI 182,780 are reported herein. A greater number of genes showed up- or down regulation when the mice were co-treated with estrogen and one of the SERMs than when dosed with one of the compounds alone. A combination of a SERM and 17[beta]-estradiol resulted in a combinatorial or synergistic effect. These data may be explained by the fact that dual administration of a SERM with [beta]-estradiol allows the compounds to bind combinatorially to heterodimers as well as homdimers of the two receptors ER[alpha] and ER[beta]. These studies provide a framework of how 17[beta]-estradiol and various SERMs act in the uterus and might result in future therapies for gynecological maladies, including endometrial cancer
Cataloging source
MUU
http://library.link/vocab/creatorName
Davis, Angela Marie
Degree
M.S.
Dissertation year
2007.
Granting institution
University of Missouri-Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorDate
1940-
http://library.link/vocab/relatedWorkOrContributorName
  • Rosenfeld, Cheryl S.
  • Roberts, R. M.
http://library.link/vocab/subjectName
  • Selective estrogen receptor modulators
  • Raloxifene
  • Generative organs, Female
  • Estrogen
  • Cancer cells
Target audience
specialized
Label
The effects of the selective estrogen receptor modulators MPP and raloxifene in normal and cancerous human and murine uterine tissue, by Angela Marie Davis, (electronic resource)
Instantiates
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from title screen of research.pdf file (viewed on March 21, 2008)
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
mixed
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
213814888
Dimensions
unknown
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)213814888
System details
Mode of access: World Wide Web
Label
The effects of the selective estrogen receptor modulators MPP and raloxifene in normal and cancerous human and murine uterine tissue, by Angela Marie Davis, (electronic resource)
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from title screen of research.pdf file (viewed on March 21, 2008)
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
mixed
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
213814888
Dimensions
unknown
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)213814888
System details
Mode of access: World Wide Web

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