The Resource The mRNA Metabolism in Human Disease, edited by Luísa Romão
The mRNA Metabolism in Human Disease, edited by Luísa Romão
Resource Information
The item The mRNA Metabolism in Human Disease, edited by Luísa Romão represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Missouri Libraries.This item is available to borrow from 1 library branch.
Resource Information
The item The mRNA Metabolism in Human Disease, edited by Luísa Romão represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Missouri Libraries.
This item is available to borrow from 1 library branch.
- Summary
- The eukaryotic gene expression pathway involves a number of interlinked steps, with messenger RNA (mRNA) being the key intermediate. The precursor mRNA is transcribed from DNA, processed by removal of introns and addition of the cap structure and the poly(A) tail. The mature mRNA is then exported to the cytoplasm where it is translated into protein and finally degraded. In this process, mRNA is associated with RNA-binding proteins forming ribonucleoprotein complexes, whose protein content evolves throughout the lifetime of the mRNA. While the complexity of eukaryotic gene expression allows the production of proteins to be controlled at many levels, it also makes the process vulnerable to errors. Although eukaryotic cells have evolved elaborate mRNA quality control mechanisms that ensure the fidelity of gene expression, some defects are not detected, thus affecting mRNA metabolism. This condition plays a fundamental role in the pathogenesis of several disease processes, such as neurodegeneration and oncogenesis. Besides, exciting recent data have shown that cellular RNAs can be modified post-transcriptionally via dynamic and reversible chemical modifications, the so-called epitranscriptome. These modifications can alter mRNA structure, being able to modulate different steps of the mRNA metabolism that can be associated with various human diseases, such as systemic lupus erythematosus and cancer. This book provides a collection of novel studies and hypotheses aimed to define the pathophysiological consequences of altered mRNA metabolism events in human cells, and is written for a wide spectrum of readers in the field of gene expression regulation. The last chapter highlights how the discovery of disease-causing defects (or modifications) in mRNA can provide a variety of therapeutic targets that can be used for the development of new RNA-based therapeutics. Hopefully, it may also contribute to inspire the drug-developing scientific community.
- Language
- eng
- Edition
- 1st ed. 2019.
- Extent
- IX, 180 p. 18 illus., 17 illus. in color.
- Contents
-
- Prelims
- Networks of mRNA processing and alternative splicing regulation in health and disease
- The diverse roles of RNA-binding proteins in glioma development
- Nonsense-mediated mRNA decay in development, stress and cancer
- Implication of mRNA degradation disorders on human DISease: focus on DIS3 and DIS3-like enzymes
- Translational regulation by upstream open reading frames and human diseases
- Alternative mechanisms of mRNA translation initiation in cellular stress response and cancer
- RNA therapeutics: how far have we gone? Index
- Isbn
- 9783030199661
- Label
- The mRNA Metabolism in Human Disease
- Title
- The mRNA Metabolism in Human Disease
- Statement of responsibility
- edited by Luísa Romão
- Language
- eng
- Summary
- The eukaryotic gene expression pathway involves a number of interlinked steps, with messenger RNA (mRNA) being the key intermediate. The precursor mRNA is transcribed from DNA, processed by removal of introns and addition of the cap structure and the poly(A) tail. The mature mRNA is then exported to the cytoplasm where it is translated into protein and finally degraded. In this process, mRNA is associated with RNA-binding proteins forming ribonucleoprotein complexes, whose protein content evolves throughout the lifetime of the mRNA. While the complexity of eukaryotic gene expression allows the production of proteins to be controlled at many levels, it also makes the process vulnerable to errors. Although eukaryotic cells have evolved elaborate mRNA quality control mechanisms that ensure the fidelity of gene expression, some defects are not detected, thus affecting mRNA metabolism. This condition plays a fundamental role in the pathogenesis of several disease processes, such as neurodegeneration and oncogenesis. Besides, exciting recent data have shown that cellular RNAs can be modified post-transcriptionally via dynamic and reversible chemical modifications, the so-called epitranscriptome. These modifications can alter mRNA structure, being able to modulate different steps of the mRNA metabolism that can be associated with various human diseases, such as systemic lupus erythematosus and cancer. This book provides a collection of novel studies and hypotheses aimed to define the pathophysiological consequences of altered mRNA metabolism events in human cells, and is written for a wide spectrum of readers in the field of gene expression regulation. The last chapter highlights how the discovery of disease-causing defects (or modifications) in mRNA can provide a variety of therapeutic targets that can be used for the development of new RNA-based therapeutics. Hopefully, it may also contribute to inspire the drug-developing scientific community.
- Dewey number
-
- 611.01816
- 599.935
- http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsedt
- niw1RhVecfA
- Illustrations
- phonodisk
- LC call number
-
- RB155-155.8
- QH431
- Literary form
- non fiction
- Nature of contents
-
- reviews
- dictionaries
- http://library.link/vocab/relatedWorkOrContributorName
- Romão, Luísa.
- Series statement
- Advances in Experimental Medicine and Biology,
- Series volume
- volume 1157
- http://library.link/vocab/subjectName
-
- Human genetics
- Cancer research
- Molecular biology
- Nucleic acids
- Label
- The mRNA Metabolism in Human Disease, edited by Luísa Romão
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Contents
- Prelims -- Networks of mRNA processing and alternative splicing regulation in health and disease -- The diverse roles of RNA-binding proteins in glioma development -- Nonsense-mediated mRNA decay in development, stress and cancer -- Implication of mRNA degradation disorders on human DISease: focus on DIS3 and DIS3-like enzymes -- Translational regulation by upstream open reading frames and human diseases -- Alternative mechanisms of mRNA translation initiation in cellular stress response and cancer -- RNA therapeutics: how far have we gone? Index
- Control code
- MUHSLdda9783030199661
- Edition
- 1st ed. 2019.
- Extent
- IX, 180 p. 18 illus., 17 illus. in color.
- Form of item
- electronic
- Isbn
- 9783030199661
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Other control number
- 10.1007/978-3-030-19966-1
- Other physical details
- online resource.
- Specific material designation
- remote
- Label
- The mRNA Metabolism in Human Disease, edited by Luísa Romão
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Contents
- Prelims -- Networks of mRNA processing and alternative splicing regulation in health and disease -- The diverse roles of RNA-binding proteins in glioma development -- Nonsense-mediated mRNA decay in development, stress and cancer -- Implication of mRNA degradation disorders on human DISease: focus on DIS3 and DIS3-like enzymes -- Translational regulation by upstream open reading frames and human diseases -- Alternative mechanisms of mRNA translation initiation in cellular stress response and cancer -- RNA therapeutics: how far have we gone? Index
- Control code
- MUHSLdda9783030199661
- Edition
- 1st ed. 2019.
- Extent
- IX, 180 p. 18 illus., 17 illus. in color.
- Form of item
- electronic
- Isbn
- 9783030199661
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Other control number
- 10.1007/978-3-030-19966-1
- Other physical details
- online resource.
- Specific material designation
- remote
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