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The Resource The mRNA Metabolism in Human Disease, edited by Luísa Romão

The mRNA Metabolism in Human Disease, edited by Luísa Romão

Label
The mRNA Metabolism in Human Disease
Title
The mRNA Metabolism in Human Disease
Statement of responsibility
edited by Luísa Romão
Contributor
Editor
Editor
Subject
Language
eng
Summary
The eukaryotic gene expression pathway involves a number of interlinked steps, with messenger RNA (mRNA) being the key intermediate. The precursor mRNA is transcribed from DNA, processed by removal of introns and addition of the cap structure and the poly(A) tail. The mature mRNA is then exported to the cytoplasm where it is translated into protein and finally degraded. In this process, mRNA is associated with RNA-binding proteins forming ribonucleoprotein complexes, whose protein content evolves throughout the lifetime of the mRNA. While the complexity of eukaryotic gene expression allows the production of proteins to be controlled at many levels, it also makes the process vulnerable to errors. Although eukaryotic cells have evolved elaborate mRNA quality control mechanisms that ensure the fidelity of gene expression, some defects are not detected, thus affecting mRNA metabolism. This condition plays a fundamental role in the pathogenesis of several disease processes, such as neurodegeneration and oncogenesis. Besides, exciting recent data have shown that cellular RNAs can be modified post-transcriptionally via dynamic and reversible chemical modifications, the so-called epitranscriptome. These modifications can alter mRNA structure, being able to modulate different steps of the mRNA metabolism that can be associated with various human diseases, such as systemic lupus erythematosus and cancer. This book provides a collection of novel studies and hypotheses aimed to define the pathophysiological consequences of altered mRNA metabolism events in human cells, and is written for a wide spectrum of readers in the field of gene expression regulation. The last chapter highlights how the discovery of disease-causing defects (or modifications) in mRNA can provide a variety of therapeutic targets that can be used for the development of new RNA-based therapeutics. Hopefully, it may also contribute to inspire the drug-developing scientific community.
Member of
Dewey number
  • 611.01816
  • 599.935
http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsedt
niw1RhVecfA
Illustrations
phonodisk
LC call number
  • RB155-155.8
  • QH431
Literary form
non fiction
Nature of contents
  • reviews
  • dictionaries
http://library.link/vocab/relatedWorkOrContributorName
Romão, Luísa.
Series statement
Advances in Experimental Medicine and Biology,
Series volume
volume 1157
http://library.link/vocab/subjectName
  • Human genetics
  • Cancer research
  • Molecular biology
  • Nucleic acids
Label
The mRNA Metabolism in Human Disease, edited by Luísa Romão
Instantiates
Publication
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Prelims -- Networks of mRNA processing and alternative splicing regulation in health and disease -- The diverse roles of RNA-binding proteins in glioma development -- Nonsense-mediated mRNA decay in development, stress and cancer -- Implication of mRNA degradation disorders on human DISease: focus on DIS3 and DIS3-like enzymes -- Translational regulation by upstream open reading frames and human diseases -- Alternative mechanisms of mRNA translation initiation in cellular stress response and cancer -- RNA therapeutics: how far have we gone? Index
Control code
MUHSLdda9783030199661
Edition
1st ed. 2019.
Extent
IX, 180 p. 18 illus., 17 illus. in color.
Form of item
electronic
Isbn
9783030199661
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-3-030-19966-1
Other physical details
online resource.
Specific material designation
remote
Label
The mRNA Metabolism in Human Disease, edited by Luísa Romão
Publication
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Prelims -- Networks of mRNA processing and alternative splicing regulation in health and disease -- The diverse roles of RNA-binding proteins in glioma development -- Nonsense-mediated mRNA decay in development, stress and cancer -- Implication of mRNA degradation disorders on human DISease: focus on DIS3 and DIS3-like enzymes -- Translational regulation by upstream open reading frames and human diseases -- Alternative mechanisms of mRNA translation initiation in cellular stress response and cancer -- RNA therapeutics: how far have we gone? Index
Control code
MUHSLdda9783030199661
Edition
1st ed. 2019.
Extent
IX, 180 p. 18 illus., 17 illus. in color.
Form of item
electronic
Isbn
9783030199661
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-3-030-19966-1
Other physical details
online resource.
Specific material designation
remote

Library Locations

    • J. Otto Lottes Health Sciences LibraryBorrow it
      1 Hospital Dr, Columbia, MO, 65201, US
      38.939544 -92.328377
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