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The Resource The neuroendocrine Leydig cells and their stem cell progenitors, the pericytes, Michail S. Davidoff [and others]

The neuroendocrine Leydig cells and their stem cell progenitors, the pericytes, Michail S. Davidoff [and others]

Label
The neuroendocrine Leydig cells and their stem cell progenitors, the pericytes
Title
The neuroendocrine Leydig cells and their stem cell progenitors, the pericytes
Statement of responsibility
Michail S. Davidoff [and others]
Contributor
Subject
Language
eng
Summary
"The Leydig cells of the testis represent the main source of androgens. The idea of Leydig cells as endocrine cells has been the leading characteristic of this interesting cell population till now. Our studies of the last 2 decades allowed us to reveal a new important feature of Leydig cells that is their obvious similarity with structures of the central and peripheral nervous system. This includes the expression of neurohormones, neurotransmitters, neuropeptides and glial cell antigens. In this way, it became evident that in addition to the well established control by steroids and systemic hormones, important local auto- and paracrine control mechanisms of testicular functions exist." "Thus, the Leydig cells represent a specialized cell population with both endocrine and neuroendocrine properties. The discovery of the neuroendocrine features of Leydig cells gave rise to the hypothesis of a potential neuroectodermal and/or neural crest origin of testicular Leydig cells. In an experimental animal model we revealed that adult Leydig cells originate by transdifferentiation from stem/progenitor cells (pericytes and smooth muscle cells), underlying the close relationship of Leydig cells with testis microvasculature. This and the supporting data from the literature provided the basis for revealing the pericytes as a common adult stem cell type of mammalian species. Distributed by the microvasculature through the entire body, the pericyte, acting as a resting early pluripotent adult stem cell, provides an ingenious system to assure the maintenance, physiological repair and regeneration of organs, each under the influence of specific local environmental factors."--BOOK JACKET
Member of
Cataloging source
PFM
Illustrations
illustrations
Index
index present
LC call number
QP255
LC item number
.N38 2009
Literary form
non fiction
Nature of contents
bibliography
http://library.link/vocab/relatedWorkOrContributorName
Davidov, Mikhail S
Series statement
Advances in anatomy, embryology and cell biology,
Series volume
205
http://library.link/vocab/subjectName
  • Leydig cells
  • Paraneurons
  • Stem cells
  • Leydig Cells
  • Pericytes
  • Stem Cells
Label
The neuroendocrine Leydig cells and their stem cell progenitors, the pericytes, Michail S. Davidoff [and others]
Instantiates
Publication
Bibliography note
Includes bibliographical references (pages [109]-149) and index
Carrier category
volume
Carrier category code
nc
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
495711209
Dimensions
24 cm
Extent
ix, 154 pages
Isbn
9783642005121
Isbn Type
(pbk. : alk. paper)
Media category
unmediated
Media MARC source
rdamedia
Media type code
n
Other physical details
illustrations (some color)
System control number
(OCoLC)495711209
Label
The neuroendocrine Leydig cells and their stem cell progenitors, the pericytes, Michail S. Davidoff [and others]
Publication
Bibliography note
Includes bibliographical references (pages [109]-149) and index
Carrier category
volume
Carrier category code
nc
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
495711209
Dimensions
24 cm
Extent
ix, 154 pages
Isbn
9783642005121
Isbn Type
(pbk. : alk. paper)
Media category
unmediated
Media MARC source
rdamedia
Media type code
n
Other physical details
illustrations (some color)
System control number
(OCoLC)495711209

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