Coverart for item
The Resource Therapeutic applications of ribozymes, edited by Kevin J. Scanlon

Therapeutic applications of ribozymes, edited by Kevin J. Scanlon

Label
Therapeutic applications of ribozymes
Title
Therapeutic applications of ribozymes
Statement of responsibility
edited by Kevin J. Scanlon
Contributor
Subject
Genre
Language
eng
Summary
In Therapeutic Applications of Ribozymes, expert laboratory scientists describe in detail their methodologies for constructing ribozymes designed to elucidate the role of specific genes as key routes to the development of novel therapies for a wide variety of diseases. The authors review the many sites targeted with ribozymes in various diseases and provide specific accounts of the practical techniques required for the proper use of ribozymes in these systems. Their cutting-edge protocols demonstrate how to achieve ribozyme expression in distinct cellular systems, the preparation and use of high-efficiency ribozyme DNA or RNA delivery, and the studies required to prove the efficacy of ribozyme-mediated inhibition, with its concomitant effect on phenotypic parameters. Therapeutic Applications of Ribozymes contains all the practical detail necessary to realize the high promise of ribozyme technology as a significant, widely used methodology. Focused on ribozyme targets and the novel associated technology, the book immediately becomes the leading resource for all those seeking to transform this new category of therapeutic agent into efficacious clinical practice
Member of
Action
digitized
Cataloging source
YUS
Dewey number
616/.042
Illustrations
illustrations
Index
index present
Language note
English
LC call number
RM666.R554
LC item number
T47 1998
Literary form
non fiction
NAL call number
RM666.R554T47
NAL item number
1998
Nature of contents
  • dictionaries
  • bibliography
NLM call number
QU 58.7 T398 1998
http://library.link/vocab/relatedWorkOrContributorDate
1947-
http://library.link/vocab/relatedWorkOrContributorName
Scanlon, Kevin J.
Series statement
Methods in molecular medicine
Series volume
11
http://library.link/vocab/subjectName
  • Catalytic RNA
  • Catalytic RNA
  • Genetic Therapy
  • Methods
  • RNA, Catalytic
  • Investigative Techniques
  • RNA, Untranslated
  • Genetic Engineering
  • Biological Therapy
  • Enzymes
  • Enzymes and Coenzymes
  • RNA
  • Genetic Techniques
  • Therapeutics
  • Nucleic Acids
  • Nucleic Acids, Nucleotides, and Nucleosides
  • Catalytic RNA
  • Catalytic RNA
  • Ribozymes
  • Therapeutische werking
  • Wetenschappelijke technieken
Label
Therapeutic applications of ribozymes, edited by Kevin J. Scanlon
Instantiates
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Small efficient hammerhead ribozymes -- The hairpin ribozyme: discovery and development for gene therapy -- Molecular manipulations of the catalytic RNAs from the human hepatitis delta virus -- The design, production, and validation of an anti-HIV type 1 ribozyme -- Methods for Treating HIV by Gene therapy using ribozymes -- An expression vector for multiple ribozymes -- Viral RNA targets for ribozymes: influenza A virus -- Hammerhead ribozyme-mediated cleavage of hepatitis B virus RNA -- Bovine leukemia virus ribozymes -- Use of ribozymes to specifically alter the MDR-1 phenotype -- Adenoviral-mediated anti-H-ras ribozyme for the treatment of bladder cancer -- Tissue-specific delivery of an anti-H-ras ribozyme against malignant melanoma -- Ribozymes as a novel approach for the treatment of human pancreatic carcinoma -- K-ras ribozyme for lung cancer -- Anti-c-erb-B-2 Ribozyme for breast cancer -- Ribozymes: applications in cancer metastasis research -- Preformed ribozymes: Strategies for design and in vivo application as anticytokine agents -- Folate-polylysine-mediated delivery of a multiunit anti-BCR/ABL ribozyme to BCR/ABL-transformed 32D cells -- Ribozymes targeted against AML1/MTG8: evaluation of ribozyme efficiency in a cell-free system and transfection with cationic liposome -- Ribozyme targeting of the growth factor pleiotrophin -- Ribozyme-mediated inhibition of cell proliferation: a model for identifying and refining a therapeutic ribozyme -- Inhibition of 13APP synthesis by ribozymes and oligonucleotides in a coupled reticulocyte transcription translation system -- Selective modification of fatty acid synthesis pathway by expression of an acetyI-CoA carboxylase-specific ribozyme gene -- In vivo knockout of a tissue-specific gene by synthetic ribozymes -- Ribozyme-mediated downregulation of gene expression in transgenic mice -- Targeted cleavage of RNA using external guide sequences and eukaryotic RNase P -- A PCR-based approach to hammerhead ribozyme synthesis-- PCR-based approach to hammerhead ribozyme synthesis -- Measurement of ribozyme activity using RNase protection
Control code
55698103
Dimensions
unknown
Extent
1 online resource (xiv, 462 pages)
File format
unknown
Form of item
online
Isbn
9781592595952
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1385/0896034771.
Other physical details
illustrations.
Quality assurance targets
unknown
Reformatting quality
unknown
Reproduction note
Electronic reproduction.
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)55698103
System details
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
Label
Therapeutic applications of ribozymes, edited by Kevin J. Scanlon
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Small efficient hammerhead ribozymes -- The hairpin ribozyme: discovery and development for gene therapy -- Molecular manipulations of the catalytic RNAs from the human hepatitis delta virus -- The design, production, and validation of an anti-HIV type 1 ribozyme -- Methods for Treating HIV by Gene therapy using ribozymes -- An expression vector for multiple ribozymes -- Viral RNA targets for ribozymes: influenza A virus -- Hammerhead ribozyme-mediated cleavage of hepatitis B virus RNA -- Bovine leukemia virus ribozymes -- Use of ribozymes to specifically alter the MDR-1 phenotype -- Adenoviral-mediated anti-H-ras ribozyme for the treatment of bladder cancer -- Tissue-specific delivery of an anti-H-ras ribozyme against malignant melanoma -- Ribozymes as a novel approach for the treatment of human pancreatic carcinoma -- K-ras ribozyme for lung cancer -- Anti-c-erb-B-2 Ribozyme for breast cancer -- Ribozymes: applications in cancer metastasis research -- Preformed ribozymes: Strategies for design and in vivo application as anticytokine agents -- Folate-polylysine-mediated delivery of a multiunit anti-BCR/ABL ribozyme to BCR/ABL-transformed 32D cells -- Ribozymes targeted against AML1/MTG8: evaluation of ribozyme efficiency in a cell-free system and transfection with cationic liposome -- Ribozyme targeting of the growth factor pleiotrophin -- Ribozyme-mediated inhibition of cell proliferation: a model for identifying and refining a therapeutic ribozyme -- Inhibition of 13APP synthesis by ribozymes and oligonucleotides in a coupled reticulocyte transcription translation system -- Selective modification of fatty acid synthesis pathway by expression of an acetyI-CoA carboxylase-specific ribozyme gene -- In vivo knockout of a tissue-specific gene by synthetic ribozymes -- Ribozyme-mediated downregulation of gene expression in transgenic mice -- Targeted cleavage of RNA using external guide sequences and eukaryotic RNase P -- A PCR-based approach to hammerhead ribozyme synthesis-- PCR-based approach to hammerhead ribozyme synthesis -- Measurement of ribozyme activity using RNase protection
Control code
55698103
Dimensions
unknown
Extent
1 online resource (xiv, 462 pages)
File format
unknown
Form of item
online
Isbn
9781592595952
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1385/0896034771.
Other physical details
illustrations.
Quality assurance targets
unknown
Reformatting quality
unknown
Reproduction note
Electronic reproduction.
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)55698103
System details
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.

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